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Association between treatment for retinopathy of prematurity and blood monocyte counts

  • Clinical Investigation
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Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate blood monocyte counts as a risk factor for retinopathy of prematurity (ROP) treatment.

Design

Retrospective cohort study.

Methods

Infants who underwent ROP screening at Shiga University of Medical Science Hospital between January, 2011 and July, 2021 were included in this study. Screening criteria were a gestational age (GA) < 32 weeks or birth weight (BW) < 1500 g. The week with the largest difference in monocyte counts between the infants with and without type 1 ROP determined based on the effect size. Multivariate logistic regression analysis was applied to investigate whether the monocyte counts constituted an independent risk factor for type 1 ROP. The objective variable was type 1 ROP, and the explanatory variables were GA, BW, infants’ infection, and Apgar score at 1 min and monocyte counts in the week with the largest monocyte-counts difference between the with- and without type 1 ROP groups.

Results

In total, 231 infants met the inclusion criteria. The monocyte counts in the fourth week after birth (4w MONO) exhibited the largest difference between infants with and without type 1 ROP. The analysis was performed on 198 infants, excluding 33 infants without 4w MONO data. Thirty-one infants had type 1 ROP, whereas 167 infants did not. BW and 4w MONO were significantly associated with type 1 ROP (odds ratio: 0.52 and 3.9, P < .001 and 0.004, respectively).

Conclusions

The 4w MONO was an independent risk factor for type 1 ROP and may be useful in follow-up of infants with ROP.

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Acknowledgements

We thank Shoji Momokawa and Jun Matsubayashi from the Center for Clinical Research and Advanced Medicine, Shiga University of Medical Science, for their advice on statistical analysis. We also thank Ryan Chastain-Gross, Ph.D., from Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, Shiga University of Medical Science, Shiga, Japan

    Shumpei Obata, Riko Matsumoto, Masashi Kakinoki, Osamu Sawada, Tomoko Sawada, Yoshitsugu Saishin & Masahito Ohji

  2. Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan

    Takahide Yanagi & Yoshihiro Maruo

Authors
  1. Shumpei Obata
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  2. Riko Matsumoto
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  3. Masashi Kakinoki
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  4. Osamu Sawada
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  5. Tomoko Sawada
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  6. Yoshitsugu Saishin
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  7. Takahide Yanagi
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  8. Yoshihiro Maruo
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  9. Masahito Ohji
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Corresponding author

Correspondence to Shumpei Obata.

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Conflict of interest

S. Obata, None; R. Matsumoto, None; M. Kakinoki, None; O. Sawada, None; T. Sawada, None; Y. Saishin, None; T. Yanagi, None; Y. Maruo, None; and M. Ohji, None.

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Corresponding Author: Shumpei Obata

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Obata, S., Matsumoto, R., Kakinoki, M. et al. Association between treatment for retinopathy of prematurity and blood monocyte counts. Jpn J Ophthalmol 67, 382–386 (2023). https://doi.org/10.1007/s10384-023-00992-x

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  • DOI: https://doi.org/10.1007/s10384-023-00992-x

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