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Relationship between vitreoretinal lymphoma and the site of lymphoma development in the central nervous system

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate diffuse large B-cell lymphoma lesions with central nervous system (CNS) involvement in patients with vitreoretinal lymphoma (VRL) during long-term clinical courses.

Study design

Multicenter, retrospective, and observational research.

Methods

Seventy-one patients participated in this study, 45 were newly diagnosed VRL patients with CNS involvement initially or during follow-up of at least 12 months. We identified the CNS lesions in the patients that had VRL and investigated whether the onset sites of the CNS lesions were associated with the VRL lesions or optic pathways.

Results

There were 42 patients with bilateral ocular lesions; 29 had unilateral lesions; 26 had incidental CNS lymphomas. Twenty patients developed recurrent CNS lymphoma 1–73 months after VRL diagnosis; 25 patients had no CNS lesions during the follow-up period. Most CNS lesions were in forebrain-originating tissues (95 lesions/total 124 CNS lesions total), followed by hindbrain-originating tissues, especially the cerebellum. Sixty-seven lesions were found in the non-optic pathway or non-visual cortex.

Conclusion

Over 60% of the VRL patients had CNS lesions. CNS involvement was not associated with the optic pathway or visual cortex, suggesting that clinicians should carefully examine CNS lesions occurring in both forebrain- and hindbrain-originating tissues during a patient’s clinical course. Moreover, the CNS lymphomas that manifest as VRL show multifocal tumor development.

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Acknowledgements

The professional English editing was performed by Editage (https://www.editage.jp/?medium=ppc&source=rbsp).

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Authors and Affiliations

  1. Department of Vision Informatics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

    Kazuichi Maruyama

  2. Department of Ophthalmology, Faculty of Medicine, Kindai University, Sayama, Osaka, Japan

    Chiharu Iwahashi

  3. Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

    Kazuichi Maruyama, Noriyasu Hashida & Kohji Nishida

  4. Department of Ophthalmology, Japan Community Health Care Organization Osaka Hospital, Osaka, Osaka, Japan

    Nobuyuki Ohguro

  5. Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, 565-0871, Japan

    Kazuichi Maruyama & Kohji Nishida

Authors
  1. Kazuichi Maruyama
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  2. Chiharu Iwahashi
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  3. Noriyasu Hashida
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  4. Nobuyuki Ohguro
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  5. Kohji Nishida
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Corresponding author

Correspondence to Kazuichi Maruyama.

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Conflicts of interests

K. Maruyama, None; C. Iwahashi, None; N. Hashida, None; N. Ohguro, None; K. Nishida, None.

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Corresponding Author: Kazuichi Maruyama

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Maruyama, K., Iwahashi, C., Hashida, N. et al. Relationship between vitreoretinal lymphoma and the site of lymphoma development in the central nervous system. Jpn J Ophthalmol 66, 142–150 (2022). https://doi.org/10.1007/s10384-021-00891-z

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  • DOI: https://doi.org/10.1007/s10384-021-00891-z

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