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Significant correlations between focal photopic negative response and focal visual sensitivity and ganglion cell complex thickness in glaucomatous eyes

  • Clinical Investigation
  • Published:
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Abstract

Purpose

To determine whether there are significant correlations between the focal photopic negative response (PhNR), the focal visual sensitivity and the ganglion cell complex (GCC) thickness in glaucomatous eyes.

Study design

Single-center observational study.

Methods

Fifty-two eyes of 52 patients (71.4 ± 9.42 years) with clinically diagnosed open angle glaucoma were studied. Thirty-six age-matched normal subjects served as controls. The focal PhNR of the focal macular electroretinograms (fmERGs) were elicited by a 15° circular, a superior semicircular or an inferior semicircular stimulus centered on the fovea. The thickness of the GCC was measured in the corresponding retinal areas in the spectral-domain optical coherence tomographic images. The visual sensitivities (dB) were measured by microperimetry at the retinal area where the fmERGs were elicited and were converted to liner values (1/Lambert).

Results

The focal PhNR amplitudes were significantly correlated with the visual sensitivities of the full-circle (R = 0.532), the superior (R = 0.530) and inferior (R = 0.526) semicircular responses (P < 0.0001). The GCC thickness was correlated with the visual sensitivities in the same areas with stronger correlations (R = 0.700, 0.759 and 0.650, respectively; P < 0.0001). The focal PhNR amplitudes were proportionally reduced with the thinning of the GCC thickness (R = 0.494, 0.518 and 0.511, respectively; P < 0.0001).

Conclusions

The significant correlations between the focal PhNR amplitudes, the focal visual sensitivities and the GCC thickness indicate that these may be good biomarkers to track the changes in the physiology and anatomy of the macular area in glaucomatous eyes.

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Acknowledgements

This study was supported by JSPS KAKENHI Grant Number 18K09420 (SM). We thank Professor Emeritus Duco Hamasaki of the Bascom Palmer Eye Institute for discussions and editing this manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minami-Koshigaya Koshigaya, Saitama, 343-8555, Japan

    Masahiko Ishizuka, Shigeki Machida, Yuji Hara, Atsushi Tada, Satoshi Ebihara, Mana Gonmori & Tomoharu Nishimura

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  1. Masahiko Ishizuka
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  2. Shigeki Machida
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Correspondence to Shigeki Machida.

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M. Ishizuka, None; S. Machida, None; Y. Hara, None; A. Tada, None; S. Ebihara, None; M. Gonmori, None; T. Nishimura, None.

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Corresponding author: Shigeki Machida

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Ishizuka, M., Machida, S., Hara, Y. et al. Significant correlations between focal photopic negative response and focal visual sensitivity and ganglion cell complex thickness in glaucomatous eyes. Jpn J Ophthalmol 66, 41–51 (2022). https://doi.org/10.1007/s10384-021-00886-w

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  • DOI: https://doi.org/10.1007/s10384-021-00886-w

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