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Peripapillary choroidal thickness assessed by spectral-domain optical coherence tomography in normal Japanese



To investigate peripapillary choroidal thickness (PPCT) in normal Japanese subjects by using spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) technique and evaluate its association with ocular and systemic factors.

Study Design

Cross-sectional study.


This study included 85 eyes of 85 normal Japanese subjects. Normal subjects were defined as those without retinal and optic nerve disorders of any kind. The PPCT was measured at the location of 3.4 mm diameter peripapillary circle centered on the optic nerve head. It was measured as the distance between the retinal pigment epithelium and scleral-choroidal interface at the following six sectors; temporal, supra-temporal, supra-nasal, nasal, infero-nasal, and infero-temporal. Global PPCT was calculated based on these sectorial data. In addition, association between the PPCT and ocular and systemic factors were evaluated.


Among the included subjects, 39 (45.9%) were men and mean age was 51.4 ± 17.6 years. The mean global PPCT was 135.8 ± 40.6 µm. The infero-nasal and infero-temporal sectors were significantly thinner than other sectors (all, P < 0.05). In multiple regression analysis, thinner global PPCT was significantly associated with older age (P < 0.0001) and female sex (P = 0.0330) after considering effects of other confounders.


This study provided global PPCT and its profile in normal Japanese subjects by using EDI SD-OCT. These results may be used as a reference in the assessment of normal status of the PPCT. The age and sex of the subjects should be considered in interpreting the PPCT data.

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The authors thank Assistant Professor Toyoto Iwata, Department of Environmental and Public Health, Akita University Graduate School of Medicine, for his help in the statistical analysis. This study was supported by the grant from the Japan society for the promotion of science (JSPS) (number; 17k11417), Tokyo, Japan.

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Correspondence to Yu Sawada.

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H. Shibata, None; Y. Sawada, None; M. Ishikawa, None; T. Yoshitomi, None; T. Iwase, None.

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Corresponding Author: Yu Sawada.

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Shibata, H., Sawada, Y., Ishikawa, M. et al. Peripapillary choroidal thickness assessed by spectral-domain optical coherence tomography in normal Japanese. Jpn J Ophthalmol 65, 666–671 (2021).

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  • Choroidal thickness
  • Peripapillary choroid
  • Optic nerve head
  • Spectral-domain optical coherence tomography
  • Glaucoma