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Evaluation of fornix-based trabeculectomy outcomes in Japanese glaucoma patients based on concrete long-term preoperative data

  • Clinical Investigation
  • Published:
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Abstract

Purpose

To investigate the outcomes of fornix-based trabeculectomy in Japanese patients with glaucoma based on more than five years of preoperative data.

Study design

Retrospective case series

Methods

This study consisted of 35 eyes of 35 Japanese glaucoma patients (mean age: 60.6, standard deviation (SD) 11.5 years) who received initial fornix-based trabeculectomy from a single ophthalmology clinic, with one or more reliable visual field test results per year from at least five years before and after the surgery. Measurements included postoperative mean intraocular pressure (IOP), standard deviation of IOP, medication scores, mean deviation slope, and total deviation slope were evaluated based on preoperative data. The relationship between mean IOP, SD-IOP and the visual field (VF) deterioration speed was also analysed.

Results

The mean follow-up period before surgery was 6.15 (SD 0.97) years and post surgery it was 5.95 (SD 0.63) years. The preoperative mean IOP of 14.6 (SD 2.3) mmHg significantly decreased to 9.2 (SD 2.2) mmHg (P <.001). The preoperative medication score 2.7 (SD 0.5) significantly decreased to 0.1 (SD 0.4, P <.001). The preoperative MD slope of −0.52 (SE 0.047) dB/year significantly improved to −0.31 (SE 0.14) dB/year (P <.01), with improvement in the superior hemifield (P ≤.018). Inferior hemifield (P >.10) did not follow the trend. Neither mean IOP nor SD-IOP correlated with the VF deterioration speed.

Conclusions

Fornix-based trabeculectomy is an acceptable procedure for initial surgical management of glaucoma, especially for maintenance of superior VF.

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Authors and Affiliations

  1. Department of Ophthalmology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Asahi Fujita, Rei Sakata, Koji Ueda, Kosuke Nakajima, Takashi Fujishiro, Megumi Honjo & Makoto Aihara

  2. Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

    Asahi Fujita

  3. Yotsuya Shirato Eye Clinic, Tokyo, Japan

    Rei Sakata, Takashi Fujishiro, Megumi Honjo, Shiroaki Shirato & Makoto Aihara

  4. Showa General Hospital, Tokyo, Japan

    Kosuke Nakajima

Authors
  1. Asahi Fujita
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  2. Rei Sakata
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Corresponding author

Correspondence to Rei Sakata.

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Conflicts of interest

A. Fujita, None; R. Sakata, None; K. Ueda, None; K. Nakajima, None; T. Fujishiro, None; M. Honjo, None; S. Shirato, None; M. Aihara, Financial support (Novartis, Pfizer, Kowa, Otsuka, Wakamoto, Nitten, Johnson & Johnson, Glaukos, TOMEY, Ono, Crewt Medical Systems, Sato, Santen, Senju, Alcon), Consultant fee (Pfizer, Kowa, Otsuka, Wakamoto, HOYA, InnFocus, Glaukos, IRIDEX, Crewt Medical Systems, Astellas, Santen, Senju, Alcon), Lecture fee, Non-Financial Support (Novartis, Pfizer, Kowa, Otsuka, Nitten, Johnson & Johnson, HOYA, Glaukos, TOMEY, IRIDEX, Crewt Medical Systems, Canon, ZEISS, Sato, Santen, Senju, Alcon).

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Corresponding Author: Rei Sakata

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Fujita, A., Sakata, R., Ueda, K. et al. Evaluation of fornix-based trabeculectomy outcomes in Japanese glaucoma patients based on concrete long-term preoperative data. Jpn J Ophthalmol 65, 306–312 (2021). https://doi.org/10.1007/s10384-020-00797-2

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  • DOI: https://doi.org/10.1007/s10384-020-00797-2

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