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Baerveldt glaucoma drainage implant surgery for secondary glaucoma in patients with transthyretin-related familial amyloid polyneuropathy

  • Clinical Investigation
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Abstract

Purpose

To investigate outcomes associated with Baerveldt glaucoma drainage implant (BGI) surgery for refractory glaucoma secondary to transthyretin (TTR)-related familial amyloid polyneuropathy (FAP) with TTR Val30Met mutation.

Study design

Retrospective case series.

Methods

Medical records of 5 eyes of 4 patients were reviewed. All patients had refractory glaucoma secondary to FAP with a history of unsuccessful intraocular pressure (IOP) control by trabeculectomy with mitomycin C, underwent BGI surgery, and were followed up for at least 1 year. The primary outcome was mean postoperative IOP, and secondary outcomes included the number of ocular hypotensive medications and postoperative complications.

Results

The mean postoperative follow-up period was 52.4 months. The mean preoperative IOP of 37.0 mmHg was reduced to 13.4 mmHg immediately postoperatively, and respective subsequent means were 15.8, 13.0, 14.4, and 16.8 mmHg at 1, 3, 6, 12, and 24 months (P < 0.05). The preoperative mean number of ocular hypotensive medications of 5.4 was reduced to respective means of 2.2, 1.6, 2.8, 2.8, and 2.8 at 1, 3, 6, 12, and 24 months. One eye suffered from IOP elevation and underwent cyclophotocoagulation at 26 months. Another was dropped from further analyses because of deterioration in the patient’s general condition due to FAP progression. The remaining 3 eyes exhibited adequate IOP control (13, 13, 13 mmHg) at the final visit.

Conclusion

BGI surgery may be the current optimal treatment for patients with refractory glaucoma secondary to TTR-FAP with regard to achieving long-term IOP reduction.

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References

  1. Hazenberg BP. Amyloidosis: a clinical overview. Rheum Dis Clin N Am. 2013;39:323–45.

    Article  Google Scholar 

  2. Plante-Bordeneuve V, Said G. Familial amyloid polyneuropathy. Lancet Neurol. 2011;10:1086–97.

    Article  CAS  Google Scholar 

  3. Dohrn MF, Rocken C, De Bleecker JL, Martin JJ, Vorgerd M, Van den Bergh PY, et al. Diagnostic hallmarks and pitfalls in late-onset progressive transthyretin-related amyloid-neuropathy. J Neurol. 2013;260:3093–108.

    Article  CAS  Google Scholar 

  4. Haraoka K, Ando Y, Ando E, Sandgren O, Hirata A, Nakamura M, et al. Amyloid deposition in ocular tissues of patients with familial amyloidotic polyneuropathy (FAP). Amyloid. 2002;9:183–9.

    Article  CAS  Google Scholar 

  5. Ando E, Ando Y, Okamura R, Uchino M, Ando M, Negi A. Ocular manifestations of familial amyloidotic polyneuropathy type I: long-term follow up. Br J Ophthalmol. 1997;81:295–8.

    Article  CAS  Google Scholar 

  6. Rousseau A, Terrada C, Touhami S, Barreau E, Rothschild PR, Valleix S, et al. Angiographic signatures of the predominant form of familial transthyretin amyloidosis (Val30Met Mutation). Am J Ophthalmol. 2018;192:169–77.

    Article  CAS  Google Scholar 

  7. Reynolds MM, Veverka KK, Gertz MA, Dispenzieri A, Zeldenrust SR, Leung N, et al. Ocular manifestations of familial transthyretin amyloidosis. Am J Ophthalmol. 2017;183:156–62.

    Article  CAS  Google Scholar 

  8. Venkatesh P, Selvan H, Singh SB, Gupta D, Kashyap S, Temkar S, et al. Vitreous amyloidosis: ocular, systemic, and genetic insights. Ophthalmology. 2017;124:1014–22.

    Article  Google Scholar 

  9. Beirao JM, Matos ME, Beirao IB, Costa PP, Torres PA. Topical cyclosporine for severe dry eye disease in liver-transplanted Portuguese patients with familial amyloidotic polyneuropathy (ATTRV30M). Eur J Ophthalmol. 2013;23:156–63.

    Article  Google Scholar 

  10. Kimura A, Ando E, Fukushima M, Koga T, Hirata A, Arimura K, et al. Secondary glaucoma in patients with familial amyloidotic polyneuropathy. Arch Ophthalmol. 2003;121:351–6.

    Article  Google Scholar 

  11. Gundapaneni BK, Sultan MB, Keohane DJ, Schwartz JH. Tafamidis delays neurological progression comparably across Val30Met and non-Val30Met genotypes in transthyretin familial amyloid polyneuropathy. Eur J Neurol. 2018;25:464–8.

    Article  CAS  Google Scholar 

  12. Miyahara T, Ohta K, Yamamoto Y, Ueno A, Murata T. 25-gauge vitrectomy to treat ocular complications of familial amyloid polyneuropathy. J Glaucoma. 2007;16:169–70.

    Article  Google Scholar 

  13. Beirao NM, Matos ME, Meneres MJ, Beirao IM, Costa PP, Torres PA. Vitreous surgery impact in glaucoma development in liver transplanted familial amyloidosis ATTR V30M Portuguese patients. Amyloid. 2012;19:146–51.

    Article  CAS  Google Scholar 

  14. Latasiewicz M, Milla E, Giralt J, Molina JJ, Matas J. Nonpenetrating deep sclerectomy as an effective treatment of glaucoma related to familial amyloid polyneuropathy. J Glaucoma. 2015;24:e80–e8383.

    Article  Google Scholar 

  15. Kawaji T, Inoue T, Hara R, Eiki D, Ando Y, Tanihara H. Long-term outcomes and complications of trabeculectomy for secondary glaucoma in patients with familial amyloidotic polyneuropathy. PLoS ONE. 2014;9:e96324.

    Article  Google Scholar 

  16. Shoji N, Kasahara M, Iijima A, Takahashi M, Tatsui S, Matsumura K, et al. Short-term evaluation of Trabectome surgery performed on Japanese patients with open-angle glaucoma. Jpn J Ophthalmol. 2016;60:156–65.

    Article  CAS  Google Scholar 

  17. Christakis PG, Kalenak JW, Tsai JC, Zurakowski D, Kammer JA, Harasymowycz PJ, et al. The ahmed versus baerveldt study: five-year treatment outcomes. Ophthalmology. 2016;123:2093–102.

    Article  Google Scholar 

  18. Sekijima Y, Wiseman RL, Matteson J, Hammarstrom P, Miller SR, Sawkar AR, et al. The biological and chemical basis for tissue-selective amyloid disease. Cell. 2005;121:73–85.

    Article  CAS  Google Scholar 

  19. Hara R, Kawaji T, Ando E, Ohya Y, Ando Y, Tanihara H. Impact of liver transplantation on transthyretin-related ocular amyloidosis in Japanese patients. Arch Ophthalmol. 2010;128:206–10.

    Article  Google Scholar 

  20. Monteiro C, da Silva AM, Ferreira N, Mesgarzadeh J, Novais M, Coelho T, et al. Cerebrospinal fluid and vitreous body exposure to orally administered tafamidis in hereditary ATTRV30M (p.TTRV50M) amyloidosis patients. Amyloid. 2018;25:120–8.

    Article  CAS  Google Scholar 

  21. Bezerra F, Simoes CJV, Beirao JM, Saraiva MJ, Brito RMM, Almeida MR. Targeting transthyretin amyloidosis in the eye with next-generation stabilizers: AT40 displays potent TTR stabilization in the human vitreous. Amyloid. 2019;26:73–4.

    Article  Google Scholar 

  22. Ishii T, Sekijima Y, Ando Y. Patient profile with ATTR-FAP and evaluation of the safety and efficacy of tafamidis meglumine in Japan - interim analysis in post-marketing surveillance. Amyloid. 2019;26:45–6.

    Article  Google Scholar 

  23. Buxbaum JN, Brannagan T 3rd, Buades-Reines J, Cisneros E, Conceicao I, Kyriakides T, et al. Transthyretin deposition in the eye in the era of effective therapy for hereditary ATTRV30M amyloidosis. Amyloid. 2019;26:10–4.

    Article  CAS  Google Scholar 

  24. Kawaji T, Ando Y, Nakamura M, Yamashita T, Wakita M, Ando E, et al. Ocular amyloid angiopathy associated with familial amyloidotic polyneuropathy caused by amyloidogenic transthyretin Y114C. Ophthalmology. 2005;112:2212.

    Article  Google Scholar 

  25. Takihara Y, Inatani M, Fukushima M, Iwao K, Iwao M, Tanihara H. Trabeculectomy with mitomycin C for neovascular glaucoma: prognostic factors for surgical failure. Am J Ophthalmol. 2009;147:912–8.

    Article  CAS  Google Scholar 

  26. Dunlop AA, Graham SL. Familial amyloidotic polyneuropathy presenting with rubeotic glaucoma. Clin Exp Ophthalmol. 2002;30:300–2.

    Article  Google Scholar 

  27. Tokumo K, Kobayashi K, Kiuchi Y. Tube implant surgery for the treatment of amyloidotic glaucoma. Jpn J Ophthalmic Surg. 2016;29:685–9 (published in (Japanese)).

    Google Scholar 

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Acknowledgements

The authors thank the Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine for introducing TTR-FAP patients to our department and the paramedical staff members in our team for helping to make this study possible. We would like to thank Editage (www.editage.com) for their writing support.

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Authors and Affiliations

  1. Department of Ophthalmology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Shinji Kakihara, Takao Hirano, Akira Imai, Teruyoshi Miyahara & Toshinori Murata

Authors
  1. Shinji Kakihara
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  2. Takao Hirano
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  3. Akira Imai
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  4. Teruyoshi Miyahara
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  5. Toshinori Murata
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Corresponding author

Correspondence to Takao Hirano.

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Conflicts of interest

S. Kakihara None; T. Hirano, Lecture fee, Consultant fee (Novartis), Lecture fee (Bayer), Consultant fee (Kowa); A. Imai, Lecture fee (Pfizer); T. Miyahara, Lecture fee (Pfizer, Senju, Santen); T. Murata, Lecture fee, Consultant fee (Novartis, Santen, Bayer), Lecture fee (Ono), Consultant fee (Daiich-Sankyo).

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Corresponding Author: Takao Hirano

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Kakihara, S., Hirano, T., Imai, A. et al. Baerveldt glaucoma drainage implant surgery for secondary glaucoma in patients with transthyretin-related familial amyloid polyneuropathy. Jpn J Ophthalmol 64, 533–538 (2020). https://doi.org/10.1007/s10384-020-00753-0

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  • DOI: https://doi.org/10.1007/s10384-020-00753-0

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