Abstract
Purpose
To evaluate the relationship between peripapillary tilt and visual field (VF) defects in glaucomatous eyes with axial myopia.
Study design
Retrospective cross-sectional study.
Patients and methods
One hundred four eyes of 104 patients with primary open-angle glaucoma (POAG) with myopia were included (52 eyes with high myopia [HM], 26.5 mm ≤ axial length [AL] < 30.0 mm; and 52 eyes without HM, 24.0 mm < AL < 26.5 mm). The direction and magnitude of the peripapillary tilt were evaluated using optical coherence tomography. The eyes were divided into 12 groups according to the tilt directions defined by clock-hour sectors in a clockwise direction in the right eyes and in a counterclockwise direction in the left eyes. The mean deviation (MD) and central VF (CVF) values, ie, the mean threshold values of 4 paracentral points within 5 degrees of the Swedish Interactive Threshold Algorithm 30–2 test, were evaluated.
Results
The direction of the tilt was toward sector 9 (47.1%) and sector 8 (34.6%). The MD and CVF values were significantly worse (P = 0.013 and P = 0.019, respectively) in the sector 9 group than in the sector 8 group. Furthermore, the smaller peripapillary tilt magnitude in the sector 9 group was negatively correlated (P = 0.0019) with the CVF but not with the MD (P = 0.1) among the POAG eyes with HM. In contrast, the ovality index in the sector 9 group was not significantly correlated with the MD (P = 0.4) or the CVF (P = 0.36).
Conclusion
A smaller temporal peripapillary tilt correlated with CVF defects in POAG eyes with HM. The peripapillary tilt direction and magnitude affect the CVF defect in POAG eyes with HM.
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S. Usui, None; Y. Ikuno, None; T. Asai, None; T. Kikawa, Employee (Topcon); M. Akiba, Employee (Topcon); A. Miki, Honorarium (Santen, Pfizer, Kowa, Otsuka, Alcon, Topcon, Novartis, HOYA, Ellex, JFC, Senju); K. Matsushita, Lecture fee(Alcon, Kowa, Nitten, Otsuka, Pfizer, Santen, Senju), Lecture fee, Advisory fee (Maruho);R. Kawasaki, Endowed Department Chair (Topcon), Grant (Senju, Novartis, Pfizer), Advisory fee (Office Future, Predictive Analytics, MICIN); K. Nishida, Grant (Topcon).
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Usui, S., Ikuno, Y., Asai, T. et al. Effect of peripapillary tilt direction and magnitude on central visual field defects in primary open-angle glaucoma with high myopia. Jpn J Ophthalmol 64, 414–422 (2020). https://doi.org/10.1007/s10384-020-00747-y
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DOI: https://doi.org/10.1007/s10384-020-00747-y