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Japanese Journal of Ophthalmology

, Volume 62, Issue 5, pp 537–543 | Cite as

Effect of spectacle lenses designed to reduce relative peripheral hyperopia on myopia progression in Japanese children: a 2-year multicenter randomized controlled trial

  • Hiroyuki Kanda
  • Tetsuro Oshika
  • Takahiro Hiraoka
  • Satoshi Hasebe
  • Kyoko Ohno-Matsui
  • Satoshi Ishiko
  • Osamu Hieda
  • Hidemasa Torii
  • Saulius R. Varnas
  • Takashi FujikadoEmail author
Clinical Investigation

Abstract

Purpose

Novel spectacle lenses (MyoVision, Carl Zeiss) designed to reduce relative peripheral hyperopia have been developed and reported to be effective for preventing myopia progression in a subgroup of Chinese children. In this study we examined the efficacy of MyoVision lenses in Japanese children.

Study design

This was a multicenter prospective randomized double-blind placebo-controlled trial.

Method

We enrolled 207 participants (aged 6–12 years) with spherical equivalent refractions (SERs) ranging from −1.5 to −4.5 diopters (D) and with at least 1 myopic parent. The participants were randomized to receive either single vision lenses (SVLs) or MyoVision lenses and were followed up every 6 months for 2 years. The primary outcome was myopia progression evaluated by cycloplegic autorefraction, and the secondary outcome was elongation of axial length.

Results

A total of 203 children (98.1%) completed the follow-up. The mean adjusted change in SER was −1.43 ± 0.10 D in the MyoVision group, which was not significantly different from that of the control group wearing SVLs (−1.39 ± 0.07 D) at the 24-month visit (P = .65). The adjusted axial length elongation was 0.73 ± 0.04 mm in the MyoVision group, which was not significantly different from that in the control group wearing SVLs (0.69 ± 0.03 mm) at the 24-month visit (P = .28).

Conclusion

The results of this clinical trial could not verify the therapeutic effect of MyoVision for slowing down myopia progression in Japanese children. Additional studies are needed to design lenses that can reduce peripheral hyperopic defocus individually and to examine the effectiveness of these lenses in preventing myopia progression.

Keywords

Myopia Myopia progression control Peripheral hyperopic defocus 

Notes

Acknowledgements

We thank the participants and certified orthoptists involved in this clinical trial. We also thank Professor Ayumu Shintani for valuable advice in the statistical analyses. This study was supported by the Japan Ophthalmologists Association.

Conflicts of interest

H. Kanda, None; T. Oshika, None; T. Hiraoka, None; S. Hasebe, None; K. Ohno, None; S. Ishiko, None; O. Hieda, None; H. Torii, None; S. R. Varnas, Employee (Carl Zeiss Vision Australia); T. Fujikado, None.

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Copyright information

© Japanese Ophthalmological Society 2018

Authors and Affiliations

  • Hiroyuki Kanda
    • 1
  • Tetsuro Oshika
    • 2
  • Takahiro Hiraoka
    • 2
  • Satoshi Hasebe
    • 3
  • Kyoko Ohno-Matsui
    • 4
  • Satoshi Ishiko
    • 5
  • Osamu Hieda
    • 6
  • Hidemasa Torii
    • 7
  • Saulius R. Varnas
    • 8
  • Takashi Fujikado
    • 1
    Email author
  1. 1.Department of Applied Visual ScienceOsaka University Graduate School of MedicineSuitaJapan
  2. 2.Department of Ophthalmology, Faculty of MedicineUniversity of TsukubaTsukubaJapan
  3. 3.Department of OphthalmologyKawasaki Medical UniversityKurashikiJapan
  4. 4.Department of Ophthalmology and Visual ScienceTokyo Medical and Dental UniversityTokyoJapan
  5. 5.Department of Medicine and Engineering Combined Research InstituteAsahikawa Medical UniversityAsahikawaJapan
  6. 6.Department of OphthalmologyKyoto Prefectural University of MedicineKyotoJapan
  7. 7.Department of OphthalmologyKeio University School of MedicineTokyoJapan
  8. 8.ZEISS-Business Group Vision Care, Technology and InnovationAdelaideAustralia

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