Japanese Journal of Ophthalmology

, Volume 62, Issue 3, pp 342–348 | Cite as

Detection of increase in corneal irregularity due to pterygium using Fourier series harmonic analyses with multiple diameters

  • Keiichiro MinamiEmail author
  • Kazunori Miyata
  • Atsushi Otani
  • Tadatoshi Tokunaga
  • Shouta Tokuda
  • Shiro Amano
Clinical Investigation



To determine steep increase of corneal irregularity induced by advancement of pterygium.


A total of 456 eyes from 456 consecutive patients with primary pterygia were examined for corneal topography and advancement of pterygium with respect to the corneal diameter. Corneal irregularity induced by the pterygium advancement was evaluated by Fourier harmonic analyses of the topographic data that were modified for a series of analysis diameters from 1 mm to 6 mm. Incidences of steep increases in the asymmetry or higher-order irregularity components (inflection points) were determined by using segmented regression analysis for each analysis diameter.


The pterygium advancement ranged from 2% to 57%, with a mean of 22.0%. Both components showed steep increases from the inflection points. The inflection points in the higher-order irregularity component altered with the analysis diameter (14.0%–30.6%), while there was no alternation in the asymmetry components (35.5%–36.8%). For the former component, the values at the inflection points were obtained in a range of 0.16 to 0.25 D.


The Fourier harmonic analyses for a series of analysis diameters revealed that the higher-order irregularity component increased with the pterygium advancement. The analysis results confirmed the precedence of corneal irregularity due to pterygium advancement.


Corneal topography Fourier harmonic analyses Higher-order irregularity Pterygium 


Conflicts of interest

K. Minami, Grant (Alcon, AMO Japan, HOYA, Otsuka Pharmaceutical, Santen Pharmaceutical, Senju Pharmaceutical, Tomey), Consultant fees (Alcon, AMO Japan, Tomey), Software modification (Tomey), P (Pending); K. Miyata, Grant (Alcon, AMO, HOYA, Otsuka Pharmaceutical, Santen Pharmaceutical, Senju Pharmaceutical, Tomey), Consultant fees (Alcon, HOYA), Lecture fees (Alcon, AMO, Chuo Sangio, HOYA, Otsuka Pharmaceutical, Senju Pharmaceutical, Tomey), Software modification (Tomey), P (Pending); A. Otani, Employee (Tomey), P (Pending); T. Tokunaga, Grant (Alcon, AMO, HOYA, Otsuka Pharmaceutical, Santen Pharmaceutical, Senju Pharmaceutical, Tomey), Software modification (Tomey); S. Tokuda, Grant (Alcon, AMO, HOYA, Otsuka Pharmaceutical, Santen Pharmaceutical, Senju Pharmaceutical, Tomey), Software modification (Tomey); S. Amano, Grant (Alcon, MSD, Novartis Pharmaceutical, Otsuka Pharmaceutical, Santen Pharmaceutical, Senju Pharmaceutical), Lecture fees (AMO, MSD, HOYA, Novartis Pharmaceutical, Otsuka Pharmaceutical, Santen Pharmaceutical, Senju Pharmaceutical).


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Copyright information

© Japanese Ophthalmological Society 2018

Authors and Affiliations

  1. 1.Miyata Eye HospitalMiyakonojoJapan
  2. 2.Kagoshima Miyata Eye ClinicKagoshimaJapan
  3. 3.Tomey CorporationNagoyaJapan
  4. 4.Inouye Eye HospitalTokyoJapan

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