Japanese Journal of Ophthalmology

, Volume 62, Issue 2, pp 216–220 | Cite as

Effect of laser peripheral iridotomy using argon and neodymium-YAG lasers on corneal endothelial cell density: 7-year longitudinal evaluation

  • Takashi Ono
  • Masaharu Iida
  • Toshihiro Sakisaka
  • Keiichiro MinamiEmail author
  • Kazunori Miyata
Clinical Investigation



To evaluate the changes in corneal endothelial cell density (ECD) over a 7-year period after laser peripheral iridotomy (LPI) using argon and neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers.

Study design

Retrospective case series.


Eyes that underwent prophylactic LPI using argon and Nd:YAG lasers were followed up for 7 years. Central corneal endothelial cells were observed by use of noncontact specular microscopy preoperatively and at 1 and 7 years postoperatively. Changes in ECD and the associations between preoperative ECD and the total energy of the Nd:YAG laser were evaluated.


Fifty-one eyes of 51 patients were followed up for 7 years. The ECD significantly decreased after LPI (P < 0.049), and the reduction rate at 1 year after the surgery (1.69 ± 4.80%, 95% CI: 0.34%–3.04%) was significantly higher than the annual reduction rates after 1 year (0.17 ± 0.85%/y, P = 0.036, 95% CI: -0.07% to 0.41%). No association was found between the preoperative ECD and the total laser energy.


Long-term evaluation indicated that the reduction in ECD after argon-Nd:YAG laser LPI was present but small during the initial year and was negligible after 1 year.


Laser peripheral iridotomy Laser peripheral iridectomy Corneal endothelial cell Nd:YAG laser Long-term reduction 


Conflicts of interest

T. Ono, Grant (Santen Pharmaceutical), Lecture fee (Senju Pharmaceutical); M. Iida, None; T. Sakisaka, None; K. Minami, Grant (Alcon, AMO, HOYA, Mitsubishi Chemical Medience, Otsuka Pharmaceutical, Santen Pharmaceutical, Senju Pharmaceutical), Consultant fees (Alcon, AMO, Chuo Sangyo); K. Miyata, Grant (Alcon, AMO, HOYA, Mitsubishi Chemical Medience, Otsuka Pharmaceutical, Santen Pharmaceutical, Senju Pharmaceutical), Consultant fee (Alcon), Lecture fees (Alcon, AMO, HOYA, MSD, Otsuka Pharmaceutical, Pfizer, Santen Pharmaceutical, Senju Pharmaceutical).

Financial disclosures

No author has a financial or proprietary interest in any material or method mentioned herein.


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Copyright information

© Japanese Ophthalmological Society 2018

Authors and Affiliations

  1. 1.Miyata Eye HospitalMiyakonojoJapan
  2. 2.Department of OphthalmologyUniversity of TokyoTokyoJapan

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