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Effect of laser peripheral iridotomy using argon and neodymium-YAG lasers on corneal endothelial cell density: 7-year longitudinal evaluation

Japanese Journal of Ophthalmology volume 62, pages 216–220 (2018)Cite this article

Abstract

Purpose

To evaluate the changes in corneal endothelial cell density (ECD) over a 7-year period after laser peripheral iridotomy (LPI) using argon and neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers.

Study design

Retrospective case series.

Methods

Eyes that underwent prophylactic LPI using argon and Nd:YAG lasers were followed up for 7 years. Central corneal endothelial cells were observed by use of noncontact specular microscopy preoperatively and at 1 and 7 years postoperatively. Changes in ECD and the associations between preoperative ECD and the total energy of the Nd:YAG laser were evaluated.

Results

Fifty-one eyes of 51 patients were followed up for 7 years. The ECD significantly decreased after LPI (P < 0.049), and the reduction rate at 1 year after the surgery (1.69 ± 4.80%, 95% CI: 0.34%–3.04%) was significantly higher than the annual reduction rates after 1 year (0.17 ± 0.85%/y, P = 0.036, 95% CI: -0.07% to 0.41%). No association was found between the preoperative ECD and the total laser energy.

Conclusions

Long-term evaluation indicated that the reduction in ECD after argon-Nd:YAG laser LPI was present but small during the initial year and was negligible after 1 year.

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Author information

Affiliations

  1. Miyata Eye Hospital, 6-3 Kurahara-cho, Miyakonojo, Miyazaki, 885-0051, Japan

    Takashi Ono, Masaharu Iida, Keiichiro Minami & Kazunori Miyata

  2. Department of Ophthalmology, University of Tokyo, Tokyo, Japan

    Toshihiro Sakisaka

Authors
  1. Takashi Ono
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  2. Masaharu Iida
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  3. Toshihiro Sakisaka
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  4. Keiichiro Minami
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  5. Kazunori Miyata
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Corresponding author

Correspondence to Keiichiro Minami.

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Conflicts of interest

T. Ono, Grant (Santen Pharmaceutical), Lecture fee (Senju Pharmaceutical); M. Iida, None; T. Sakisaka, None; K. Minami, Grant (Alcon, AMO, HOYA, Mitsubishi Chemical Medience, Otsuka Pharmaceutical, Santen Pharmaceutical, Senju Pharmaceutical), Consultant fees (Alcon, AMO, Chuo Sangyo); K. Miyata, Grant (Alcon, AMO, HOYA, Mitsubishi Chemical Medience, Otsuka Pharmaceutical, Santen Pharmaceutical, Senju Pharmaceutical), Consultant fee (Alcon), Lecture fees (Alcon, AMO, HOYA, MSD, Otsuka Pharmaceutical, Pfizer, Santen Pharmaceutical, Senju Pharmaceutical).

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No author has a financial or proprietary interest in any material or method mentioned herein.

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Ono, T., Iida, M., Sakisaka, T. et al. Effect of laser peripheral iridotomy using argon and neodymium-YAG lasers on corneal endothelial cell density: 7-year longitudinal evaluation. Jpn J Ophthalmol 62, 216–220 (2018). https://doi.org/10.1007/s10384-018-0569-6

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  • DOI: https://doi.org/10.1007/s10384-018-0569-6

Keywords

  • Laser peripheral iridotomy
  • Laser peripheral iridectomy
  • Corneal endothelial cell
  • Nd:YAG laser
  • Long-term reduction