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Japanese Journal of Ophthalmology

, Volume 62, Issue 2, pp 231–236 | Cite as

Changes in refractive characteristics in Japanese children with Down syndrome

  • Junna Horio
  • Hiroki KanekoEmail author
  • Kei Takayama
  • Kinichi Tuzuki
  • Hiroko Kakihara
  • Miou Iwami
  • Yoshikatsu Kawase
  • Taichi Tsunekawa
  • Naoko Yamaguchi
  • Norie Nonobe
  • Hiroko Terasaki
Clinical Investigation
  • 151 Downloads

Abstract

Purpose

To investigate the refractive characteristics of Japanese children with Down syndrome.

Study design

Retrospective study.

Methods

The clinical records of refractive errors and ocular manifestations in children with Down syndrome who visited the Aichi Children’s Health and Medical Center between November 2001 and January 2016 were retrospectively reviewed. The children were divided into the 3 following groups depending on their age: group 1 (≤ 6 years), group 2 (7–12 years), and group 3 (13–19 years). The collection of refractive error data was performed only for the right eyes and only once for each child, when the children were last examined with their pupils dilated.

Results

The study included 416 children (224 boys, 192 girls; average age, 6.1 ± 4.1 years). Group 3 had significantly stronger myopia than did groups 1 and 2. The mean cylindrical power in all the children was − 2.1 ± 1.2 diopters (D), and cylindrical power ≤ − 1.0 D (stronger than − 1.0 D) was seen in 366 eyes (88%). No significant difference in cylindrical power was found among the 3 groups.

Conclusions

The spherical equivalent refraction showed an age-dependent myopic shift. Given that the amount of astigmatism did not show age-dependent differences, the age-dependent myopic shift could be due mainly to the change in spherical power.

Keywords

Down syndrome Refractive error Myopic shift Astigmatism 

Notes

Acknowledgments

The authors thank Drs Shu Kachi, Tadasu Sugita, Masatoshi Nagaya, and Yosuke Nagasaka for their important clinical suggestions and Ms Chisato Ishizuka for technical assistance. This work was partially supported by a Grant-in-Aid for Scientific Research B (to H.T., 15H04994); a Grant-in-Aid for Young Scientists B (to H. Kaneko, 17K16963); the Chukyo Longevity Medical and Promotion Foundation (to H. Kaneko); the Takeda Medical Research Foundation (to H. Kaneko); the Takeda Science Foundation (to H. Kaneko); the Mishima Saiichi-Kinen Gankakenkyu Kokusaikouryu Kikin (to H. Kaneko); and the Itoh-Chubei Foundation (to H. Kaneko).

Author contributions

HK wrote the main manuscript. JH and HKaneko prepared the figures. JH, KT, and HK acquired the data. KT, TT, and NN analyzed the data. MI, YK, NY, NN, and HT worked on interpretation of the data and critical revision. All the authors read and approved the final manuscript.

Conflicts of interest

J. Horio, None; H. Kaneko, None; K. Takayama, None; K. Tuzuki, None; H. Kakihara, None; M. Iwami, None; Y. Kawase, None; T. Tsunekawa, None; N. Yamaguchi, None; N. Nonobe, None; H. Terasaki, None.

Supplementary material

10384_2018_565_MOESM1_ESM.docx (54 kb)
Supplementary material 1 (DOCX 54 kb)

References

  1. 1.
    Down JH. Observations on an ethnic classification of idiots. Lond Hosp Rep. 1866;3:259–62.Google Scholar
  2. 2.
    da Cunha PR, Moreira JB. Ocular findings in Down’s syndrome. Am J Ophthalmol. 1996;122:236–44.CrossRefPubMedGoogle Scholar
  3. 3.
    National Birth Defects Prevention Network. Birth defect surveillance data from selected states, 1989–1996. Teratology. 2000;61:86–158.CrossRefGoogle Scholar
  4. 4.
    Tomita K, Tsurui H, Otsuka S, Kato K, Kimura A, Shiraishi Y, et al. Ocular findings in 304 children with Down syndrome [in Japanese]. Nippon Ganka Gakkai Zasshi. 2013;117:749–60.PubMedGoogle Scholar
  5. 5.
    Kim JH, Hwang JM, Kim HJ, Yu YS. Characteristic ocular findings in Asian children with Down syndrome. Eye (Lond). 2002;16:710–4.CrossRefPubMedGoogle Scholar
  6. 6.
    Shapiro MB, France TD. The ocular features of Down’s syndrome. Am J Ophthalmol. 1985;99:659–63.CrossRefPubMedGoogle Scholar
  7. 7.
    Ljubic A, Trajkovski V. Refractive errors in children and young adults with Down’s syndrome. Acta Ophthalmol. 2011;89:324–7.CrossRefPubMedGoogle Scholar
  8. 8.
    Caputo AR, Wagner RS, Reynolds DR, Guo SQ, Goel AK. Down syndrome: clinical review of ocular features. Clin Pediatr. 1989;28:355–8.CrossRefGoogle Scholar
  9. 9.
    Hiles DA, Hoyme SH, McFarlane F. Down’s syndrome and strabismus. Am Orthopt J. 1974;24:63–8.PubMedGoogle Scholar
  10. 10.
    Gwiazda J, Thorn F, Bauer J, Held R. Emmetropization and the progression of manifest refraction in children followed from infancy to puberty. Clin Vis Sci. 1993;8:337–44.Google Scholar
  11. 11.
    Fan DS, Lam DS, Lam RF, Lau JT, Chong KS, Cheung EY, et al. Prevalence, incidence, and progression of myopia of school children in Hong Kong. Invest Ophthalmol Vis Sci. 2004;45:1071–5.CrossRefPubMedGoogle Scholar
  12. 12.
    Maul E, Barroso S, Munoz SR, Sperduto RD, Ellwein LB. Refractive error study in children: results from La Florida, Chile. Am J Ophthalmol. 2000;129:445–54.CrossRefPubMedGoogle Scholar
  13. 13.
    Woodhouse JM, Pakeman VH, Cregg M, Saunders KJ, Parker M, Fraser WI, et al. Refractive errors in young children with Down syndrome. Optom Vis Sci. 1997;74:844–51.CrossRefPubMedGoogle Scholar
  14. 14.
    Doyle SJ, Bullock J, Gray C, Spencer A, Cunningham C. Emmetropisation, axial length, and corneal topography in teenagers with Down’s syndrome. Br J Ophthalmol. 1998;82:793–6.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Haugen OH, Hovding G, Lundstrom I. Refractive development in children with Down’s syndrome: a population based, longitudinal study. Br J Ophthalmol. 2001;85:714–9.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Cregg M, Woodhouse JM, Stewart RE, Pakeman VH, Bromham NR, Gunter HL, et al. Development of refractive error and strabismus in children with Down syndrome. Invest Ophthalmol Vis Sci. 2003;44:1023–30.CrossRefPubMedGoogle Scholar
  17. 17.
    Al-Bagdady M, Murphy PJ, Woodhouse JM. Development and distribution of refractive error in children with Down’s syndrome. Br J Ophthalmol. 2011;95:1091–7.CrossRefPubMedGoogle Scholar
  18. 18.
    Kim U, Hwang JM. Refractive errors and strabismus in Asian patients with Down syndrome. Eye. 2009;23:1560–4.CrossRefPubMedGoogle Scholar
  19. 19.
    Shimizu N, Nomura H, Ando F, Niino N, Miyake Y, Shimokata H. Refractive errors and factors associated with myopia in an adult Japanese population. Jpn J Ophthalmol. 2003;47:6–12.CrossRefPubMedGoogle Scholar
  20. 20.
    Sawada A, Tomidokoro A, Araie M, Iwase A, Yamamoto T. Refractive errors in an elderly Japanese population: the Tajimi study. Ophthalmology. 2008;115:363–70.e3.CrossRefGoogle Scholar
  21. 21.
    Wong TY, Foster PJ, Hee J, Ng TP, Tielsch JM, Chew SJ, et al. Prevalence and risk factors for refractive errors in adult Chinese in Singapore. Invest Ophthalmol Vis Sci. 2000;41:2486–94.PubMedGoogle Scholar
  22. 22.
    Jung SK, Lee JH, Kakizaki H, Jee D. Prevalence of myopia and its association with body stature and educational level in 19-year-old male conscripts in Seoul, South Korea. Invest Ophthalmol Vis Sci. 2012;53:5579–83.CrossRefPubMedGoogle Scholar
  23. 23.
    Saw SM, Tong L, Chua WH, Chia KS, Koh D, Tam DT, et al. Incidence and progression of myopia in Singaporean school children. Invest Ophthalmol Vis Sci. 2005;46:51–7.CrossRefPubMedGoogle Scholar
  24. 24.
    Hamasaki I, Hasebe S, Kimura S, Miyata M, Ohtsuki H. Cycloplegic effect of 0.5% tropicamide and 0.5% phenylephrine mixed eye drops: objective assessment in Japanese schoolchildren with myopia. Jpn J Ophthalmol. 2007;51:111–5.CrossRefPubMedGoogle Scholar
  25. 25.
    Gwiazda J, Scheiman M, Mohindra I, Held R. Astigmatism in children: changes in axis and amount from birth to 6 years. Invest Ophthalmol Vis Sci. 1984;25:88–92.PubMedGoogle Scholar
  26. 26.
    Dobson V, Fulton AB, Sebris SL. Cycloplegic refractions of infants and young children: the axis of astigmatism. Invest Ophthalmol Vis Sci. 1984;25:83–7.PubMedGoogle Scholar
  27. 27.
    Howland HC, Sayles N. Photorefractive measurements of astigmatism in infants and young children. Invest Ophthalmol Vis Sci. 1984;25:93–102.PubMedGoogle Scholar
  28. 28.
    Tomita K. Visual characteristics of children with Down syndrome. Jpn J Ophthalmol. 2017;61:271–9.CrossRefPubMedGoogle Scholar

Copyright information

© Japanese Ophthalmological Society 2018

Authors and Affiliations

  • Junna Horio
    • 1
    • 2
  • Hiroki Kaneko
    • 2
    Email author
  • Kei Takayama
    • 2
    • 3
  • Kinichi Tuzuki
    • 1
  • Hiroko Kakihara
    • 1
    • 4
  • Miou Iwami
    • 2
  • Yoshikatsu Kawase
    • 5
  • Taichi Tsunekawa
    • 2
  • Naoko Yamaguchi
    • 1
  • Norie Nonobe
    • 2
  • Hiroko Terasaki
    • 2
  1. 1.Department of OphthalmologyAichi Children’s Health and Medical CenterObuJapan
  2. 2.Department of OphthalmologyNagoya University Graduate School of MedicineNagoyaJapan
  3. 3.Department of OphthalmologyNational Defense Medical CollegeTokorozawaJapan
  4. 4.Kakihara Eye ClinicToyohashiJapan
  5. 5.Faculty of Health and Medical SciencesAichi Shukutoku UniversityNagakuteJapan

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