Japanese Journal of Ophthalmology

, Volume 62, Issue 2, pp 144–150 | Cite as

Efficacy of treat-and-extend regimen with aflibercept for pachychoroid neovasculopathy and Type 1 neovascular age-related macular degeneration

  • Hidetaka MatsumotoEmail author
  • Takashi Hiroe
  • Masahiro Morimoto
  • Kensuke Mimura
  • Arisa Ito
  • Hideo Akiyama
Clinical Investigation



To evaluate the efficacy of intravitreal aflibercept therapy using a treat-and-extend regimen on treatment-naïve pachychoroid neovasculopathy (PNV) and Type 1 neovascular age-related macular degeneration (AMD).


We retrospectively studied 42 eyes with PNV and 60 eyes with Type 1 neovascular AMD. We assessed best-corrected visual acuity (BCVA), central macular thickness (CMT), central choroidal thickness (CCT), and total number of injections over 2 years.


The BCVA and CMT improvements during the 2-year treatment period did not differ significantly between PNV and AMD; however, CCT decreased significantly in PNV than in AMD (P<0.05). Management of PNV required significantly fewer injections than AMD during the 2-year period (P<0.05). There were no significant differences in BCVA, CMT and CCT changes between PNV with and without polypoidal lesions (28 vs. 14 eyes) during the 2 year period. Significantly fewer injections were needed for PNV with polypoidal lesions than for PNV without (P<0.01). There were no significant differences in BCVA, CMT and CCT changes, or in the number of injections during the 2-year treatment period, between AMD with and without polypoidal lesions (30 vs. 30 eyes).


Treat-and-extend regimen of intravitreal aflibercept injection may be equally effective in terms of improvement of BCVA and exudative changes both in eyes with PNV and those with Type 1 neovascular AMD requiring fewer injections for the former. Among eyes with PNV, those with polypoidal lesions needed fewer injections than those without polypoidal lesions.


Pachychoroid neovasculopathy (PNV) Age-related macular degeneration (AMD) Type 1 neovascularization Anti-vascular endothelial growth factor (VEGF) Treat-and-extend 


Conflicts of interest

H. Matsumoto, None; T. Hiroe, None; M. Morimoto, None; K. Mimura, None; A. Ito, None; H. Akiyama, None.


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Copyright information

© Japanese Ophthalmological Society 2018

Authors and Affiliations

  • Hidetaka Matsumoto
    • 1
    Email author
  • Takashi Hiroe
    • 1
  • Masahiro Morimoto
    • 1
  • Kensuke Mimura
    • 1
  • Arisa Ito
    • 1
  • Hideo Akiyama
    • 1
  1. 1.Department of OphthalmologyGunma University, School of MedicineMaebashiJapan

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