Japanese Journal of Ophthalmology

, Volume 62, Issue 2, pp 127–136 | Cite as

Baseline data from a multicenter, 5-year, prospective cohort study of Japanese age-related macular degeneration: an AMD2000 report

  • Akitaka TsujikawaEmail author
  • Yumiko Akagi-Kurashige
  • Mitsuko Yuzawa
  • Tatsuro Ishibashi
  • Hideo Nakanishi
  • Eiji Nakatani
  • Satoshi Teramukai
  • Masanori Fukushima
  • Nagahisa Yoshimura
  • AMD2000 Study Group
Clinical Investigation



To report research participants’ baseline characteristics in the AMD2000 study, a prospective, multicenter, 5-year, observational cohort study of Japanese age-related macular degeneration (AMD). The characteristics were determined using multimodal imaging.


Patients with AMD were recruited at 18 clinical sites in Japan between April 2006 and March 2009. Each patient underwent a complete ophthalmic examination, including measurement of best-corrected visual acuity (Landolt chart), indirect ophthalmoscopy, slit-lamp biomicroscopy with a contact lens, optical coherence tomography imaging, fundus photography, and fluorescein and indocyanine green angiography.


Four hundred sixty participants (326 men [70.9%]) were included in the study. At enrollment, 131 eyes (28.5%) had hard drusen and 125 eyes (27.2%) had soft drusen in the macular area. A total of 455 eyes (98.9%) were diagnosed as having wet AMD, and 5 eyes (1.1%), as having dry AMD. Of the 455 eyes with wet AMD, 209 eyes (45.4%) had typical AMD, 228 eyes (49.6%) had polypoidal choroidal vasculopathy (PCV), and 18 eyes (3.9%) had retinal angiomatous proliferation. The size of choroidal neovascularization (CNV) was significantly smaller with indocyanine green angiography than with fluorescein angiography (P < 0.001). Poor baseline visual acuity was associated with cystoid macular edema, older age, scar, extrafoveal macular edema, subfoveal CNV, large branching vascular network, and hard exudates.


Japanese patients with AMD are predominantly male, lack drusen, and have a high rate of PCV.


Age-related macular degeneration (AMD) Drusen Multimodal imaging International classification Polypoidal choroidal vasculopathy 



We are grateful to all the patients and coinvestigators for their cooperation in the current study. A list of the participating research sites and investigators is given in the Appendix. The authors also thank the following additional investigators at the Translational Research Informatics Center (TRI) at the Foundation for Biomedical Research and Innovation for their contributions to this trial: Ms Emiko Uno for data management; Ms Yasuko Kimura for project management; and Dr Hideaki Kaneda, Dr Shinsuke Kojima, Mr Mikio Yoshidomi, and Dr Atsuhiko Kawamoto for manuscript review.

Conflicts of Interest

A. Tsujikawa, Grant (Alcon, AMO Japan, Bayer, HOYA, Kowa, Novartis, Pfizer, Santen, Senju), Lecture fees (Alcon, AMO Japan, Bayer, Chugai, Kowa, Nidek, Novartis, Pfizer, Santen, Sanwa Kagaku, Senju); Y. Akagi-Kurashige, None; M. Yuzawa, Grant (Alcon Japan, Santen), Consultant fees (Alcon Japan, Astellas Pharma, Janssen Japan), Lecture fees (Astellas Pharma, Bausch & Lomb Japan, Bayer, Japan Focus Company, Novartis, Santen, Senju); T. Ishibashi, None; H. Nakanishi, None; E. Nakatani, None; S. Teramukai, Grant (Daiichi Sankyo), Consultant fee (Daiichi Sankyo, Sanofi, Solasia Pharma, Sysmex, Taiho Pharmaceutical), Lecture fees (Bristol-Myers Squibb, Fujifilm); M. Fukushima, None; N. Yoshimura, None.


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Copyright information

© Japanese Ophthalmological Society 2017

Authors and Affiliations

  • Akitaka Tsujikawa
    • 1
    Email author
  • Yumiko Akagi-Kurashige
    • 1
  • Mitsuko Yuzawa
    • 2
  • Tatsuro Ishibashi
    • 3
  • Hideo Nakanishi
    • 1
  • Eiji Nakatani
    • 4
  • Satoshi Teramukai
    • 4
    • 5
  • Masanori Fukushima
    • 4
  • Nagahisa Yoshimura
    • 1
  • AMD2000 Study Group
  1. 1.Department of Ophthalmology and Visual SciencesKyoto University Graduate School of MedicineKyotoJapan
  2. 2.Division of Ophthalmology, Department of Visual SciencesNihon University School of MedicineTokyoJapan
  3. 3.Department of Ophthalmology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  4. 4.Translational Research Informatics Center, Foundation for Biomedical Research and InnovationKobeJapan
  5. 5.Department of Biostatistics, Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyotoJapan

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