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Concentration of acute phase factors in vitreous fluid in diabetic macular edema

Japanese Journal of Ophthalmology volume 61, pages 479–483 (2017)Cite this article

Abstract

Purpose

Diabetic retinal maculopathy is associated with acute and chronic local inflammation. We measured the concentrations of acute phase factors in vitreous fluid of patients with diabetic macular edema (DME) and examined their relations to visual acuity and central retinal thickness (CRT) both before and after vitrectomy.

Study design

Retrospective.

Methods

Vitreous fluid was collected during vitreoretinal surgery from 19 patients with DME and 12 control subjects with epiretinal membrane. The concentrations of acute phase factors (α2-macroglobulin, haptoglobin, C-reactive protein, serum amyloid P and A, procalcitonin, ferritin, tissue plasminogen activator, fibrinogen) and vascular endothelial growth factor (VEGF) were measured with multiplex assays. CRT of macular edema was measured by optical coherence tomography (OCT).

Results

The levels of serum amyloid P, procalcitonin, ferritin, and fibrinogen in vitreous fluid were increased in DME patients compared with control subjects. The levels of procalcitonin and fibrinogen in DME patients were inversely correlated with visual acuity both before and 3 months after vitrectomy but not 6 months postsurgery. The concentrations of these four factors were not correlated with either CRT or the vitreous levels of VEGF in DME patients.

Conclusion

Acute phase factors may contribute to local inflammation in DME and may therefore influence disease progression.

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Acknowledgements

We thank Yukari Mizuno and Shizuka Murata for technical assistance as well as members of the Setouchi Vitreous Club for support.

Author information

Affiliations

  1. Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan

    Kazuhiro Kimura, Tomoko Orita & Yuka Kobayashi

  2. Jyousaigaoka Eye Clinic, 3-1-1 Inamoto Munakata, Fukuoka, 811-3406, Japan

    Shigeo Matsuyama

  3. Fujimoto Eye Clinic, 3-6-9 Taharashinmachi, Kokuraminami Ward, Kitakyushu, Fukuoka, 800-0226, Japan

    Kazushi Fujimoto

  4. Department of Ophthalmology, Japanese Red Cross Yamaguchi Hospital, 53-1 Yawatanobaba, Yamaguchi, Yamaguchi, 753-0092, Japan

    Kazuhiko Yamauchi

Authors
  1. Kazuhiro Kimura
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  2. Tomoko Orita
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  3. Yuka Kobayashi
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  4. Shigeo Matsuyama
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  5. Kazushi Fujimoto
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  6. Kazuhiko Yamauchi
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Corresponding author

Correspondence to Kazuhiro Kimura.

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Conflicts of interest

K. Kimura, None; T. Orita, None; Y. Kobayashi, None; S. Matsuyama, None; K. Fujimoto, None; K. Yamauchi, None.

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Kimura, K., Orita, T., Kobayashi, Y. et al. Concentration of acute phase factors in vitreous fluid in diabetic macular edema. Jpn J Ophthalmol 61, 479–483 (2017). https://doi.org/10.1007/s10384-017-0525-x

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  • DOI: https://doi.org/10.1007/s10384-017-0525-x

Keywords

  • Acute phase factor
  • Diabetic macular edema
  • Visual acuity
  • Central retinal thickness
  • Vascular endothelial growth factor (VEGF)