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Evaluation of graft–host interface after penetrating keratoplasty using anterior segment optical coherence tomography

  • Clinical Investigation
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Abstract

Purpose

To evaluate the characteristics of the graft–host interface after penetrating keratoplasty (PKP) using anterior segment optical coherence tomography (AS-OCT).

Methods

Forty-nine eyes of 49 patients with three different underlying diseases (corneal scar, 22 eyes; bullous keratopathy, 14 eyes; keratoconus, 13 eyes) who underwent PKP were retrospectively reviewed. AS-OCT was performed in all patients and wound profiles of the graft–host junctions were classified into well-apposed junction, gap, step, and protrusion. The correlations between clinical characteristics and wound profiles from the AS-OCT were analyzed.

Results

A total of 392 graft–host junctions from 49 eyes were analyzed. Among them, 155 sections (39.5 %) had well-apposed junctions and 237 sections (60.5 %) had malapposed junctions. The most frequent type of malapposition was protrusion (117 sections, 39.9 %). When categorizing the eyes according to the most frequent alignment type among the 8 cross-sections, the alignment pattern showed significant differences between the preoperative diagnosis groups (P = 0.04). Spherical equivalent (P = 0.04) and keratometric astigmatism (P < 0.01) showed significant differences between the alignment groups. Graft–host thickness disparities showed significant correlations with keratometric astigmatism (r = 0.56, P < 0.01) and degree of graft oversize (r = 0.29, P = 0.04).

Conclusions

The alignment pattern of wound interface after PKP differed according to the clinical diagnosis before surgery and was significantly associated with spherical equivalent and keratometric astigmatism.

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Acknowledgments

This study was partially supported by the Chonnam National University Biomedical Research Institute (CRI 13906-22) and Forest Science and Technology Projects (Project No. S121313L050100) provided by Korea Forest Service.

Conflicts of interest

M. S. Sung, None; K. C. Yoon, None.

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Authors and Affiliations

  1. Department of Ophthalmology, Chonnam National University Medical School and Hospital, Center for Creative Biomedical Scientists at Chonnam National University, 8 Hakdong, Donggu, Gwangju, 501-757, Korea

    Mi Sun Sung & Kyung Chul Yoon

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  1. Mi Sun Sung
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  2. Kyung Chul Yoon
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Correspondence to Kyung Chul Yoon.

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Sung, M.S., Yoon, K.C. Evaluation of graft–host interface after penetrating keratoplasty using anterior segment optical coherence tomography. Jpn J Ophthalmol 58, 282–289 (2014). https://doi.org/10.1007/s10384-014-0309-5

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  • DOI: https://doi.org/10.1007/s10384-014-0309-5

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