Branch retinal vein occlusion-associated subretinal hemorrhage
- 323 Downloads
To study the pathomorphology of subretinal hemorrhage (SRH) seen in eyes with branch retinal vein occlusion (BRVO) and its association with visual prognosis.
We retrospectively reviewed 42 consecutive patients (42 eyes) with BRVO that affected the fovea. Retinal structural changes were examined by spectral domain optical coherence tomography (SD-OCT).
On SD-OCT sections, serous retinal detachment was seen at the fovea in 35 eyes, 18 of which accompanied foveal SRH. While initial detection of foveal SRH had no correlation with initial visual acuity (VA), it was correlated with poorer final VA (r = 0.361, P = 0.019). Our patients were classified into two groups by the initial detection of foveal SRH, and initial VA was not different between these two groups. At the final examination, damaged lengths in the foveal photoreceptor layer were significantly longer in the SRH-positive group than those in the SRH-negative group (P = 0.004), and final VA in the SRH-positive group was significantly worse than that in the SRH-negative group (P = 0.019).
Foveal SRH is not an uncommon feature in BRVO and may cause subsequent damage to the foveal photoreceptor layer, resulting in poor visual function.
KeywordsBranch retinal vein occlusion Subretinal hemorrhage Photoreceptor damage Spectral-domain optical coherence tomography
- 23.Scott IU, VanVeldhuisen PC, Oden NL, Ip MS, Blodi BA, Hartnett ME, et al. Baseline predictors of visual acuity and retinal thickness outcomes in patients with retinal vein occlusion: Standard Care Versus COrticosteroid for REtinal Vein Occlusion Study report 10. Ophthalmology. 2011;118:345–52.PubMedCrossRefGoogle Scholar
- 33.Koshibu A. [Ultrastructural studies on absorption of experimentally produced subretinal hemorrhage. 2. Autolysis of macrophages and disappearance of erythrocytes from the subretinal space at the late stage]. Nippon Ganka Gakkai Zasshi (in Japanese). 1978;82:471–9.Google Scholar
- 34.Koshibu A. [Ultrastructural studies on absorption of an experimentally produced subretinal hemorrhage. III. Absorption of erythrocyte break down products and retinal hemosiderosis at the late stage]. Nippon Ganka Gakkai Zasshi (in Japanese). 1979;83:386–400.Google Scholar
- 38.Bhisitkul RB, Winn BJ, Lee OT, Wong J, Wong J, Wong J, Wong J, Wong J, Pereira Dde S, Porco TC, et al. Neuroprotective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in a rabbit model of subretinal hemorrhage. Invest Ophthalmol Vis Sci. 2008;49:4071–7.PubMedCrossRefGoogle Scholar