Japanese Journal of Ophthalmology

, Volume 57, Issue 3, pp 257–262 | Cite as

Positive correlation between the degree of visual field defect and optic radiation damage in glaucoma patients

  • Hideki Murai
  • Yukihisa Suzuki
  • Motohiro Kiyosawa
  • Aya M. Tokumaru
  • Kenji Ishii
  • Manabu Mochizuki
Clinical Investigation

Abstract

Purpose

We evaluated optic radiation (OR) damage in patients with glaucoma by using fractional anisotropy (FA) of diffusion-tensor magnetic resonance imaging.

Methods

We studied 29 patients with glaucoma and 19 healthy controls. Regions of interest were placed over the bilateral anterior and posterior ORs on the FA maps, and the FA value of each region was measured.

Results

FA values of the bilateral anterior and posterior ORs were significantly lower in patients with glaucoma (anterior right, P = 0.0002; anterior left, P = 0.00028; posterior right, P = 0.0004; and posterior left, P = 0.0001) than in the healthy controls. In glaucoma patients, significant correlations were observed between the FA values and the average of the total deviation of the contralateral hemifields of both eyes (left hemifield and anterior right OR, correlation coefficient [r] = 0.46 [P = 0.013]; right hemifield and anterior left OR, r = 0.43 [P = 0.021]; left hemifield and posterior right OR, r = 0.54 [P = 0.0027]; and right hemifield and posterior left OR, r = 0.46 [P = 0.012]).

Conclusions

FA values of the entire OR were decreased in glaucoma patients and correlated with the degree of visual field defect.

Keywords

Glaucoma Optic radiation Diffusion-tensor imaging 

Notes

Acknowledgments

This research was supported by Grants-in-Aid for Scientific Research (B) 21791725 (Y.S.) and (C) 20591038 (K.I.) from the Japan Society for the Promotion of Science.

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Copyright information

© Japanese Ophthalmological Society 2013

Authors and Affiliations

  • Hideki Murai
    • 1
    • 2
  • Yukihisa Suzuki
    • 1
    • 2
  • Motohiro Kiyosawa
    • 1
    • 3
  • Aya M. Tokumaru
    • 4
  • Kenji Ishii
    • 2
  • Manabu Mochizuki
    • 1
  1. 1.Department of Ophthalmology and Visual ScienceTokyo Medical and Dental University, Graduate SchoolTokyoJapan
  2. 2.Positron Medical Center, Tokyo Metropolitan Institute of GerontologyTokyoJapan
  3. 3.Kiyosawa Eye ClinicTokyoJapan
  4. 4.Department of Diagnostic RadiologyTokyo Metropolitan Geriatric Hospital and Institute of GerontologyTokyoJapan

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