Japanese Journal of Ophthalmology

, Volume 57, Issue 3, pp 245–251 | Cite as

Trabecular meshwork depigmentation in Vogt–Koyanagi–Harada disease

  • Kazuomi Mizuuchi
  • Nobuyoshi Kitaichi
  • Kenichi Namba
  • Yukihiro Horie
  • Susumu Ishida
  • Shigeaki Ohno
Clinical Investigation



Since some patients develop depigmentation of the trabecular meshwork in the course of Vogt–Koyanagi–Harada (VKH) disease, we examined the incidence of trabecular depigmentation and its correlation with other ocular findings and systemic symptoms.


We retrospectively reviewed the clinical charts of 53 Japanese patients diagnosed with VKH disease. The scores of trabecular and limbal pigmentation of all patients were recorded. We then examined the correlation between trabecular pigmentation and the presence of sunset glow fundus or skin lesions.


Trabecular pigmentation was significantly lower in the patients with sunset glow fundus than in those without it (P = 0.022), whereas limbal pigmentation showed no significance. However, there were no significant differences in trabecular and limbal pigmentation between the patients with and those without skin lesions. Furthermore, there was no correlation between trabecular and limbal pigmentation.


Depigmentation of the trabecular meshwork develops in some patients in the course of VKH disease. This depigmentation is significantly correlated with sunset glow fundus, but not with limbal depigmentation or skin lesions.


Vogt–Koyanagi–Harada disease Trabecular depigmentation Sunset grow fundus Limbal depigmentation Skin lesion 


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Copyright information

© Japanese Ophthalmological Society 2013

Authors and Affiliations

  • Kazuomi Mizuuchi
    • 1
  • Nobuyoshi Kitaichi
    • 2
    • 3
  • Kenichi Namba
    • 1
  • Yukihiro Horie
    • 1
  • Susumu Ishida
    • 1
  • Shigeaki Ohno
    • 2
  1. 1.Department of OphthalmologyHokkaido University Graduate School of MedicineSapporoJapan
  2. 2.Department of Ocular Inflammation and ImmunologyHokkaido University Graduate School of MedicineSapporoJapan
  3. 3.Department of OphthalmologyHealth Sciences University of HokkaidoSapporoJapan

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