Abstract
Purpose
To compare the biomechanical properties of the cornea in eyes with no previous surgery, with keratoconus with previous penetrating keratoplasty (PK) and with keratoconus with previous deep anterior lamellar keratoplasty (DALK) using the Reichert Ocular Response Analyzer (ORA).
Methods
One hundred twenty eyes of 120 patients were included in this prospective comparative study. Forty eyes were with no previous ocular surgery (group 1), 40 eyes were with previous PK for keratoconus (group 2), and 40 eyes were with previous DALK for keratoconus (group 3). Corneal hysteresis (CH) and the corneal resistance factor (CRF) were measured with ORA.
Results
The CH and CRF values in group 2 were significantly lower than in group 1 and group 3 (p = 0.001). The CH and CRF values were similar in group 1 and group 3. There was no statistically significant difference between group 1 and 3.
Conclusion
Although the post-PK keratoconus cornea has weaker biomechanical properties, post-DALK keratoconus cornea is similar to normal cornea. A cornea weakened by keratoconus can be strengthened with lamellar keratoplasty.
Similar content being viewed by others
References
Rabinowitz YS. Keratoconus (Review). Surv Ophthalmol. 1998;42:297–319.
Kim KH, Choi SH, Ahn K, Chung ES, Chung TY. Comparison of refractive changes after deep anterior lamellar keratoplasty and penetrating keratoplasty for keratoconus. Jpn J Ophthalmol. 2011;55:93–7.
Li X, Rabinowitz YS, Rasheed K, Yang H. Longitudinal study of the normal eyes in unilateral keratoconus patients. Ophthalmology. 2004;111:440–6.
Yenerel NM, Kucumen RB, Gorgun E. Changes in corneal biomechanics in patients with keratoconus after penetrating keratoplasty. Cornea. 2010;29:1247–51.
Fontes BM, Ambrósio R Jr, Jardim D, Velarde GC, Nosé W. Corneal biomechanical metrics and anterior segment parameters in mild keratoconus. Ophthalmology. 2010;117:673–9.
Reinhart WJ, Musch DC, Jacobs DS, Lee WB, Kaufman SC, Schtein RM. Deep anterior lamellar keratoplasty as an alternative to penetrating keratoplasty a report by American Academy of Ophthalmology. Ophthalmology. 2011;118:209–18.
Javadi MA, Feizi S, Yazdani S, Mirbabaee F. Deep anterior lamellar keratoplasty versus penetrating keratoplasty for keratoconus. A clinical trial. Cornea. 2010;29:365–71.
Luce DA. Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg. 2005;31:156–62.
Feizi S, Einollahi B, Yazdani S, Hashemloo A. Graft biomechanical properties after penetrating keratoplasty in keratoconus. Cornea. 2012;31:855–8
Shah S, Laiquzzaman M, Bhojwani R, Mantry S, Cunliffe I. Assessment of the biomechanical properties of the cornea with the ocular response analyzer in normal and keratoconic eyes. Invest Ophthalmol Vis Sci. 2007;48:3026–31.
Anwar M, Teichmann KD. Big-bubble technique to bare Descemet’s membrane in anterior lamellar keratoplasty. J Cataract Refract Surg. 2002;28:398–403.
Troutman RC, Lawless MA. Penetrating keratoplasty for keratoconus. Cornea. 1987;6:298–305.
Lim L, Pseudovs K, Coster DJ. Penetrating keratoplasty for keratoconus: visual outcome and success. Ophthalmology. 2000;107:1125–31.
Melles GR, Lander F, Rietvelt FJ, Remeijer L, Beekhuis WH, Binder PS. A new surgical technique for deep stromal, anterior lamellar keratoplasty. Br J Ophthalmol. 1999;83:327–33.
Al-Torbak AA, Al-Motowa S, Al-Assiri A, Al-Kharashi S, Al-Shahwan S, Al-Mezaine H, et al. Deep anterior lamellar keratoplasty for keratoconus. Cornea. 2006;25:408–12.
Shin JY, Choi SJ, Oh JY, Kim MK, Lee JH, Wee WR. Evaluation of corneal biomechanical properties following penetrating keratoplasty using the ocular response analyzer. Korean J Ophthalmol. 2010;24:139–42.
Edmund C. Assessment of an elastic model in the pathogenesis of keratoconus. Acta Ophthalmol. 1987;65:545–50.
Foster CS, Yamamato GK. Ocular rigidity in keratoconus. Am J Ophthalmol. 1978;86:802–6.
Edmund C. Corneal rigidity and ocular rigidity in normal and keratoconic eyes. Acta Ophthalmol. 1988;66:134–40.
Hartstein J, Becker B. Research into the pathogenesis of keratoconus: a new syndrome low ocular rigidity, contact lenses and keratoconus. Arch Ophthalmol. 1970;84:728–9.
Ortiz D, Pinero D, Shabayek MH, Arnalich-Montiel F, Alió JL. Corneal biomechanical properties in normal, post laser in situ keratomileusis, and keratoconic eyes. J Cataract Refract Surg. 2007;33:1371–5.
Qazi MA, Sanderson JP, Mahmoud AM, Yoon EY, Robetrs CJ, Pepose JS. Postoperative changes in intraocular pressure and corneal biomechanical metrics-Laser in situ keratomileusis versus laser assisted subepithelial keratectomy. J Cataract Refract Surg. 2009;35:1774–88.
Kamiya K, Shimizu K, Ohmoto F. The changes in corneal biomechanical parameters after phototherapeutic keratectomy in eyes with granular corneal dystrophy. Eye. 2009;23:1790–5.
Randleman JB, Russell B, Ward MA, Thompson KP, Stulting RD. Risk factors and prognosis for corneal ectasia after LASIK. Ophthalmology. 2003;110:267–75.
Wittig-Silva C, Whiting M, Lamoureux E, Lindsay RG, Sullivan LJ, Snibson GR. A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results. J Refract Surg. 2008;24:720–5.
Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen cross-linking with riboflavin and ultraviolet—a light in keratoconus: long-term results. J Cataract Refract Surg. 2008;34:796–801.
Vinciguerra P, Albe E, Mahmoud MM, Trazza S, Hafezi F, Roberts CJ. Intra- and postoperative variation in ocular response analyzer parameters in keratoconic eyes after corneal cross-linking. J Refract Surg. 2010;26:669–76.
Jafarinasab MR, Sepehr F, Javadi MA, Hashemloo A. Graft biomechanical properties after penetrating keratoplasty versus deep anterior lamellar keratoplasty. Curr Eye Res. 2011;36:417–21.
Hosny M, Hassaballa MAM, Shalaby A. Changes in corneal biomechanics following different keratoplasty techniques. Clin Ophthalmol. 2011;5:767–70.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Acar, B.T., Akdemir, M.O. & Acar, S. Corneal biomechanical properties in eyes with no previous surgery, with previous penetrating keratoplasty and with deep anterior lamellar keratoplasty. Jpn J Ophthalmol 57, 85–89 (2013). https://doi.org/10.1007/s10384-012-0197-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10384-012-0197-5