Japanese Journal of Ophthalmology

, Volume 57, Issue 1, pp 63–67 | Cite as

Intravitreal injection of bevacizumab: changes in intraocular pressure related to ocular axial length

  • Andrea Cacciamani
  • Francesco Oddone
  • Mariacristina Parravano
  • Fabio ScarinciEmail author
  • Marta Di Nicola
  • Giorgio Lofoco
Clinical Investigation



To evaluate the immediate and short-term effects of intravitreal injection of 1.25 mg/0.05 ml of bevacizumab on intraocular pressure related to different ocular axial lengths.


A prospective case series of consecutive patients referred to the Department of Ophthalmology, San Pietro-Fatebenefratelli Hospital, from September 2011 through January 2011.


Twenty-five patients (10 men and 15 women, mean age 70.2 ± 8.98 years) scheduled for intravitreal injection of bevacizumab for the treatment of neovascular age-related macular degeneration were enrolled in this study. Axial length was measured preoperatively using IOLMaster. Intraocular pressure was measured before injection, after 1 min and after 15 min using Tono-Pen XL tonometry.


The mean intraocular pressure change following the intravitreal bevacizumab injection was 21.92 ± 6.95 mmHg after 1 min and 6.24 ± 3.77 mmHg after 15 min. The mean axial length of the examined eyes was 23.2 ± 1.06 mm. A good correlation was observed between the axial length and intraocular pressure rise after both 1 (R 2 = 0.752, p < 0.001) and 15 min (R 2 = 0.559, p < 0.001).


Patients undergoing intravitreal injection of 0.05 ml of bevacizumab can be exposed to intraocular pressure increases correlated to ocular axial length.


Intraocular drugs Intraocular pressure Intravitreal injection 


Ethical standard

The study protocol adhered to the tenets of the Declaration of Helsinki and was approved by the local Ethics Committee. Each patient signed an informed consent before enrollment.


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Copyright information

© Japanese Ophthalmological Society 2012

Authors and Affiliations

  • Andrea Cacciamani
    • 1
  • Francesco Oddone
    • 1
  • Mariacristina Parravano
    • 1
  • Fabio Scarinci
    • 1
    Email author
  • Marta Di Nicola
    • 2
  • Giorgio Lofoco
    • 3
  1. 1.Fondazione G.B. Bietti-IRCCSRomeItaly
  2. 2.Department of Biomedical Science, Laboratory of BiostatisticsUniversity of Chieti “G. d’Annunzio”Chieti-PescaraItaly
  3. 3.Ospedale Fatebenefratelli San PietroRomeItaly

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