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Novel automated screening of age-related macular degeneration

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To determine the objective and quantitative hyperspectral parameters for distinguishing between age-related macular degeneration (AMD) and a normal macula.

Methods

Near-infrared hyperspectral images were taken of 71 eyes of 62 AMD patients with exudative AMD and 21 eyes of 12 control subjects without AMD. The spatial information included a 480 × 321-pixel image in a 50° field located at the ocular fundus and a 720–950-nm-per-pixel reflectance spectrum. Macular vectors were determined as the average spectrum for each macula, and reference vectors were used as average macular vectors for healthy volunteers. Variations in vector length and angle were calculated based on comparison with the reference vector. The AMD differentiation index was a parameter that minimized the plot overlap between AMD patients and controls.

Results

Statistically significant differences between the AMD patients and controls were noted. Receiver-operating characteristic curve analysis revealed an area under the curve of 0.888. The appropriate threshold values were attained for the proposed discrimination index, including 68 % sensitivity, 95 % specificity and 74 % accuracy.

Conclusions

This study presents a simplified diagnostic index for the determination of age-related macular degeneration based on near-infrared spectra.

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Acknowledgments

We wish to thank Shunsuke Tanaka, Yu Amano, Aiko Kuroda and Katsuhiro Nakano of department of Electrical Engineering and Bioscience, Waseda University, Tokyo, Japan, and Tsuyoshi Agawa, Maki Mishima, Yoshihiko Usui, Daisuke Muramatsu, Tsuyoshi Mizusawa, Setsuko Kawakami and Yoshihiro Wakabayashi of the Department of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan for their help in acquiring the clinical data and in the analysis of the data.

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Authors and Affiliations

  1. Department of Ophthalmology, Tokyo Medical University Hospital, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan

    Yasuyuki Yamauchi & Hiroshi Goto

  2. Department of Electrical Engineering and Bioscience, Waseda University, Tokyo, Japan

    Hiroyuki Kemma, Atsushi Nakamura & Takayuki Sota

  3. Department of Ophthalmology, Toda Chuo General Hospital, Saitama, Japan

    Yasuyuki Yamauchi

  4. Institute for Science and Engineering, Waseda University, Tokyo, Japan

    Takashi Nagaoka

Authors
  1. Yasuyuki Yamauchi
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  2. Hiroyuki Kemma
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  3. Hiroshi Goto
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  4. Atsushi Nakamura
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  5. Takashi Nagaoka
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  6. Takayuki Sota
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Correspondence to Yasuyuki Yamauchi.

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Yamauchi, Y., Kemma, H., Goto, H. et al. Novel automated screening of age-related macular degeneration. Jpn J Ophthalmol 56, 577–583 (2012). https://doi.org/10.1007/s10384-012-0184-x

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  • DOI: https://doi.org/10.1007/s10384-012-0184-x

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