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The 2009 prospective multi-center epidemiologic survey of uveitis in Japan

  • Clinical Investigation
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Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate etiologic data on intraocular inflammation in Japan collected in the 2009 epidemiologic survey of uveitis in Japan and assess the current state of etiology compared with that reported in a previous survey.

Methods

Thirty-six university hospitals participated in this prospective etiologic study. Patients who visited the outpatient uveitis clinic of each hospital for the first time between 1 June 2009 and 31 May 2010 were enrolled in the study. Uveitic diseases were diagnosed according to the guidelines when available or following commonly accepted diagnostic criteria.

Results

A total of 3,830 patients were enrolled in the survey and 2,556 cases of uveitis were identified, of which 1,274 cases were described as unclassified intraocular inflammation. In the identified cases, the most frequent intraocular inflammatory disease was sarcoidosis (10.6 %), followed by Vogt–Koyanagi–Harada disease (7.0 %), acute anterior uveitis (6.5 %), scleritis (6.1 %), herpetic iridocyclitis (4.2 %), Behçet’s disease (3.9 %), bacterial endophthalmitis (2.5 %), masquerade syndrome (2.5 %), Posner–Schlossman syndrome (1.8 %), and retinal vasculitis (1.6 %).

Conclusions

The current etiology of uveitis in Japan was elucidated by means of a multi-center prospective survey. Conducting such surveys on a periodic basis may help clinicians in their management of uveitis.

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References

  1. Derhaaq PJ, de Waal LP, Linssen A, Feltkamp TE. Acute anterior uveitis and HLA-B27 subtypes. Invest Ophthalmol Vis Sci. 1988;29:1137–40.

    Google Scholar 

  2. Levinson RD, Rajalingam R, Park MS, Reed EF, Gjertson DW, Kappel PJ, et al. Human leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy. Am J Ophthalmol. 2004;138:631–4.

    Article  PubMed  CAS  Google Scholar 

  3. Shindo Y, Inoko H, Yamamoto T, Ohno S. HLA-DRB1 typing of Vogt-Koyanagi-Harada’s disease by PCR-RFLP and the strong association with DRB1*0405 and DRB1*0410. Br J Ophthalmol. 1994;78:223–6.

    Article  PubMed  CAS  Google Scholar 

  4. Mochizuki M, Watanaebe T, Yamaguchi K, Tajima K. Human T-lymphotropic virus type 1-associated disease. In: Pepose JS, Holland GN, Wilhelmus KR, editors. Ocular infection and immunity. St. Louis: Mosby; 1996. p. 1366–87.

    Google Scholar 

  5. Chang JH, Wakefield D. Uveitis: a global perspective. Ocul Immunol Inflamm. 2002;10:263–79.

    Article  PubMed  Google Scholar 

  6. Kotake S. Epidemiology of Behçet disease. Clin Ophthalmol. 2003;57:1308–10.

    Google Scholar 

  7. Yoshida A, Kawashima H, Motoyama Y, Shibui H, Kaburaki T, Shimizu K, et al. Comparison of patients with Behçet’s disease in the 1980s and 1990s. Ophthalmology. 2004;111:810–5.

    Article  PubMed  Google Scholar 

  8. Goto H, Mochizuki M, Yamaki K, Kotake S, Usui M, Ohno S. Epidemiological survey of intraocular inflammation in Japan. Jpn J Ophthalmol. 2007;51:41–4.

    Article  PubMed  Google Scholar 

  9. Forrester JV, Okada AA, Ohno A, BenEzra D, editors. Posterior segment intraocular inflammation: guidelines. Amsterdam: Kugler; 1998.

    Google Scholar 

  10. BenEzra D, Ohno S, Secchi AG, Alio J, editors. Anterior segment intraocular inflammation: guidelines. London: Martin Dunitz; 2000.

    Google Scholar 

  11. Ministry of Health, Labour and Welfare Designated Disease Study Group. Ministry of Health, Labour and Welfare. Diagnostic criteria of Behçet’s disease (revised edition, 2003) (in Japanese). Ministry of Health, Labour and Welfare, Tokyo; 2003. pp. 11–13.

  12. Read RW, Holland GN, Rao NA, Tabbara KF, Ohno S. Arellanes-Garcia, et al. Revised diagnostic criteria for Vogt–Koyanagi–Harada disease: report of an international committee on nomenclature. Am J Ophthalmol. 2001;131:647–52.

    Article  PubMed  CAS  Google Scholar 

  13. Sugisaki K: Diagnostic guidelines and criteria for sarcoidosis—2006 (in Japanese). Nihon Kokyuki Gakkai Zasshi. 2008;46:768–80.

  14. Sakai JI, Usui Y, Sakai M, Yokoi H, Goto H. Clinical statistics of endogenous uveitis: comparison between general eye clinic and university hospital. Int Ophthalmol. 2010;30:297–301.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors wish to thank the institutions that participated in this survey: Hokkaido University, Asahikawa Medical University, Akita University, Tohoku University, Yamagata University, Fukushima Medical University, Dokkyo Medical University, Chiba University, Nihon University, Jikei University, Juntendo University, Kitasato University, Tokyo Medical University, Tokyo Medical and Dental University, University of Tokyo, Yokohama City University, Kyorin University, Gifu University, Niigata University, Kanazawa University, Kyoto University, Kyoto Prefectural University, Osaka University, Osaka Medical College, Osaka City University, Kinki University, Kobe University, Shimane University, Hiroshima University, Ehime University, Kochi University, Fukuoka University, Kyushu University, Saga University, Kurume University, Kagoshima University. The authors also express their appreciation to Dr. Chiharu Iwahashi for her help with data analysis.

Conflict of interest

The authors have no proprietary interests or conflicts of interest in any aspect of this report.

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Correspondence to Nobuyuki Ohguro.

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Ohguro, N., Sonoda, KH., Takeuchi, M. et al. The 2009 prospective multi-center epidemiologic survey of uveitis in Japan. Jpn J Ophthalmol 56, 432–435 (2012). https://doi.org/10.1007/s10384-012-0158-z

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  • DOI: https://doi.org/10.1007/s10384-012-0158-z

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