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Effects of ocular rotation on parapapillary retinal nerve fiber layer thickness analysis measured with spectral-domain optical coherence tomography

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the effects of ocular rotation on parapapillary retinal nerve fiber layer (RNFL) thickness measured by spectral-domain optical coherence tomography (SD-OCT).

Patients and methods

Eighty-eight normal and 205 glaucomatous eyes were studied. RNFL thickness was measured by 3D OCT. Ocular rotation angle was measured from a fundus image obtained by a non-mydriatic fundus camera equipped with 3D OCT. The average, hemi-superior, and hemi-inferior RNFL thicknesses as well as those in the 4 quadrants and the 16-segmented superotemporal (ST-1) and inferotemporal (IT-4) sectors were compared both before and after correcting for ocular rotation. Receiver operating characteristic curves and the areas under the curve (AUC) for the RNFL thicknesses were calculated on the basis of the data from glaucomatous and control eyes. The relationships between RNFL thickness and retinal sensitivity in the corresponding visual field were analyzed using a Humphrey field analyzer.

Results

Correction for ocular rotation did not affect the AUCs of the hemi-superior and hemi-inferior RNFL thicknesses. RNFL thicknesses in all of the quadrants and in ST-1 and IT-4 were significantly changed by correcting for ocular rotation. The correlations between all RNFL sectors and retinal sensitivity were not changed by correcting for the ocular rotation angle.

Conclusions

Ocular rotation compensation affected RNFL thickness measurement with 3D OCT. However, the effect was clinically negligible in the diagnosis of glaucoma.

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Acknowledgments

The authors wish to thank Makoto Araie, Aiko Iwase, and Atsuo Tomidokoro for their advice on establishing the study design and preparing manuscript. This study was supported by two Grants-in-Aid 22390324 (A.N., Y.Y., M.N.) and 23791983 (A.K.) for Scientific Research from the Ministry of Education, Culture, Sports, and Science and Technology of the Japanese Government, and the Suda Memorial Foundation (A.K.).

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Authors and Affiliations

  1. Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Akiyasu Kanamori, Makoto Nakamura, Kumiko Tabuchi, Yuko Yamada & Akira Negi

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  1. Akiyasu Kanamori
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  2. Makoto Nakamura
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  3. Kumiko Tabuchi
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  4. Yuko Yamada
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  5. Akira Negi
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Correspondence to Akiyasu Kanamori.

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Kanamori, A., Nakamura, M., Tabuchi, K. et al. Effects of ocular rotation on parapapillary retinal nerve fiber layer thickness analysis measured with spectral-domain optical coherence tomography. Jpn J Ophthalmol 56, 354–361 (2012). https://doi.org/10.1007/s10384-012-0143-6

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  • DOI: https://doi.org/10.1007/s10384-012-0143-6

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