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Clinical evaluation of non-Descemet stripping automated endothelial keratoplasty (nDSAEK)

  • Clinical Investigation
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Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To report the clinical outcomes of non-Descemet stripping automated endothelial keratoplasty (nDSAEK) as a treatment for endothelial dysfunction.

Methods

Nineteen eyes of 19 patients (mean age 74.2 years) with non-Fuchs-type bullous keratopathy suitable for endothelial keratoplasty were enrolled in this study. All participants underwent endothelial keratoplasty without Descemet stripping. Best corrected visual acuity (BCVA) and donor central endothelial cell density (ECD) were recorded preoperatively and postoperatively.

Results

All 19 cases had a clear graft at 1 year postoperatively. Mean BCVA improved from 0.80 logarithm of the minimum angle of resolution (logMAR) preoperatively to 0.20 logMAR after 3 months, 0.13 logMAR after 6 months, and 0.08 logMAR after 1 year. The average and standard deviations of ECD (cells/mm2) after 3 months were 2324 ± 493 (representing a 20.0% mean cell loss from preoperative donor cell measurements), 2268 ± 525 (22.0% decrease) after 6 months, and 2064 ± 665 (29.0% decrease) after 1 year. No intraoperative complications were noted. One case of transient pupillary air block was observed postoperatively.

Conclusions

This modified endothelial keratoplasty technique for the treatment of non-Fuchs-type endothelial dysfunction produced excellent clinical outcomes such as reduced endothelial cell loss and good visual acuity.

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Acknowledgments

This study was supported by a grant from the Intractable Disease Treatment Research Program (no. 10103447) of the Japanese Ministry of Health, Labour and Welfare and by a Grant-in-Aid for Scientific Research (no. 22591934).

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan

    Toshinori Masaki, Akira Kobayashi, Hideaki Yokogawa, Yoshiaki Saito & Kazuhisa Sugiyama

Authors
  1. Toshinori Masaki
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  2. Akira Kobayashi
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  3. Hideaki Yokogawa
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  4. Yoshiaki Saito
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  5. Kazuhisa Sugiyama
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Corresponding author

Correspondence to Akira Kobayashi.

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Cite this article

Masaki, T., Kobayashi, A., Yokogawa, H. et al. Clinical evaluation of non-Descemet stripping automated endothelial keratoplasty (nDSAEK). Jpn J Ophthalmol 56, 203–207 (2012). https://doi.org/10.1007/s10384-012-0123-x

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  • DOI: https://doi.org/10.1007/s10384-012-0123-x

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