Skip to main content

Advertisement

SpringerLink
Log in

Treatment of macular edema due to branch retinal vein occlusion with single or multiple intravitreal injections of bevacizumab

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

We examined the predictive factors for final visual acuity (VA) with macular edema of branch retinal vein occlusion (BRVO) treated by intravitreal injection of bevacizumab (IVB) and examined the differences between patients without recurrent macular edema due to BRVO after a single IVB and patients treated with multiple IVB because of recurrent macular edema.

Methods

In this retrospective study, 37 eyes of 37 patients with BRVO were treated with IVB and followed up for more than 24 weeks. Eighteen eyes showed no recurrence of macular edema after a single IVB (single IVB group). The remaining 19 eyes showed recurrent macular edema and underwent multiple IVB (multiple IVB group). VA and morphologic parameters of optical coherence tomography were examined.

Results

Mean VA, central retinal thickness, and mean retinal thickness in a circular region of 1-mm diameter at the fovea improved significantly with IVB treatment in both groups. Final VA was correlated with baseline VA and integrity grade of the photoreceptor inner and outer segment (IS/OS) line beneath the fovea.

Conclusion

Baseline VA and IS/OS line grade at 4 weeks may be predictive factors for final VA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Kumagai K, Furukawa M, Ogino N, Uemura A, Larson E. Long-term outcomes of vitrectomy with or without arteriovenous sheathotomy in branch retinal vein occlusion. Retina. 2007;27:49–54.

    Article  PubMed  Google Scholar 

  2. The Branch Vein Occlusion Study Group. Argon laser photocoagulation for macular edema in branch vein occlusion. Am J Ophthalmol. 1984;98:271–82.

    Google Scholar 

  3. Parodi M, DI Stefano G, Ravalico G. Grid laser treatment for exudative retinal detachment secondary to ischemic branch retinal vein occlusion. Retina. 2008;28:97–102.

    Article  PubMed  Google Scholar 

  4. Jaissle G, Leitritz M, Gelisken F, Ziemssen F, Bartz-Schmidt KU, Szurman P. One-year results after intravitreal bevacizumab therapy for macular edema secondary to branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2009;247:27–33.

    Article  PubMed  CAS  Google Scholar 

  5. Kondo M, Kondo N, Ito Y, Kachi S, Kikuchi M, Yasuma TR, et al. Intravitreal injection of bevacizumab for macular edema secondary to branch retinal vein occlusion. Retina. 2009;29:1242–8.

    Article  PubMed  Google Scholar 

  6. Kreutzer TC, Alge CS, Wolf AH, Kook D, Burger J, Strauss R, et al. Intravitreal bevacizumab for the treatment of macular oedema secondary to branch retinal vein occlusion. Br J Ophthalmol. 2008;92:351–5.

    Article  PubMed  CAS  Google Scholar 

  7. Rabena MD, Pieramici DJ, Castellarin AA, Nasir MA, Avery RL. Intravitreal bevacizumab (Avastin) in the treatment of macular edema secondary to branch retinal vein occlusion. Retina. 2007;27:419–25.

    Article  PubMed  Google Scholar 

  8. Hoeh AE, Ach T, Schaal KB, Scheuerle AF, Dithmar S. Long-term follow-up of OCT-guided bevacizumab treatment of macular edema due to retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2009;247:1635–41.

    Article  PubMed  CAS  Google Scholar 

  9. Ach T, Hoeh AE, Schaal KB, Scheuerle AF, Dithmar S. Predictive factors for changes in macular edema in intravitreal bevacizumab therapy of retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2010;248:155–9.

    Article  PubMed  CAS  Google Scholar 

  10. Hoeh AE, Ruppenstein M, Ach T, Dithmar S. OCT patterns of macular edema and response to bevacizumab therapy in retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2010;248:1567–72.

    Article  PubMed  CAS  Google Scholar 

  11. Chung EJ, Hong YT, Lee SC, Kwon OW, Koh HJ. Prognostic factors for visual outcome after intravitreal bevacizumab for macular edema due to branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2008;246:1241–8.

    Article  PubMed  CAS  Google Scholar 

  12. Mitamura Y, Hirano K, Baba T, Yamamoto S. Correlation of visual recovery with presence of photoreceptor inner/outer segment junction in optical coherence images after epiretinal membrane surgery. Br J Ophthalmol. 2008;93:171–5.

    Article  PubMed  Google Scholar 

  13. Noma H, Funatsu H, Yamasaki M, Tsukamoto H, Mimura T, Sone T, et al. Pathogenesis of macular edema with branch retinal vein occlusion and intraocular levels of vascular endothelial growth factor and interleukin-6. Am J Ophthalmol. 2005;140:256–61.

    Article  PubMed  CAS  Google Scholar 

  14. Sakamoto A, Tsujikawa A, Ota M, Yamaike N, Kotera Y, Miyamoto K, et al. Evaluation of potential visual acuity in eyes with macular oedema secondary to retinal vein occlusion. Clin Exp Ophthalmol. 2009;37:208–16.

    Article  Google Scholar 

  15. Kriechbaum K, Prager F, Geitzenauer W, Benesch T, Schütze C, Simader C, et al. Association of retinal sensitivity and morphology during antiangiogenic treatment of retinal vein occlusion over one year. Ophthalmology. 2009;116:2415–21.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan

    Tatsuya Yunoki, Akio Miyakoshi, Tomoko Nakamura, Kazuya Fujita, Chiharu Fuchizawa & Atsushi Hayashi

Authors
  1. Tatsuya Yunoki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Akio Miyakoshi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tomoko Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kazuya Fujita
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chiharu Fuchizawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Atsushi Hayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Atsushi Hayashi.

About this article

Cite this article

Yunoki, T., Miyakoshi, A., Nakamura, T. et al. Treatment of macular edema due to branch retinal vein occlusion with single or multiple intravitreal injections of bevacizumab. Jpn J Ophthalmol 56, 159–164 (2012). https://doi.org/10.1007/s10384-011-0114-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-011-0114-3

Keywords

Search

Navigation