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Negative correlation between aqueous vascular endothelial growth factor levels and axial length

  • Clinical Investigation
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Abstract

Purpose

The aim of this study was to evaluate the relationship between the concentrations of vascular endothelial growth factor (VEGF) in the aqueous humor and axial length.

Methods

Aqueous humor samples were obtained from 60 eyes of 60 patients without ocular diseases other than cataracts. No patients with diabetes mellitus were included. The VEGF concentration in the aqueous humor was measured using an enzyme-linked immunosorbent assay.

Results

The VEGF concentrations in the aqueous humor samples ranged from 25 to 241 pg/ml [mean ± standard deviation (SD), 116.6 ± 46.7 pg/ml]. The axial lengths ranged from 20.98 to 31.95 mm (mean ± SD, 24.09 ± 2.06 mm). The VEGF concentrations in the aqueous humor samples were correlated with axial length (Pearson product moment correlation test, ρ = −0.373; P = 0.003).

Conclusions

The concentration of VEGF in the aqueous humor is negatively correlated with axial length.

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Acknowledgments

This study was supported in part by a grant from the Japanese Ministry of Education, Culture, Sports, Science, and Technology (no. 21592255) and by a grant from the Japanese Ministry of Health, Labor, and Welfare.

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Authors and Affiliations

  1. Department of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowacho, Otsu, Shiga, 520-2192, Japan

    Osamu Sawada, Taichiro Miyake, Masashi Kakinoki, Tomoko Sawada, Hajime Kawamura & Masahito Ohji

Authors
  1. Osamu Sawada
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  2. Taichiro Miyake
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  3. Masashi Kakinoki
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  4. Tomoko Sawada
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  5. Hajime Kawamura
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  6. Masahito Ohji
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Corresponding author

Correspondence to Osamu Sawada.

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Cite this article

Sawada, O., Miyake, T., Kakinoki, M. et al. Negative correlation between aqueous vascular endothelial growth factor levels and axial length. Jpn J Ophthalmol 55, 401–404 (2011). https://doi.org/10.1007/s10384-011-0027-1

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  • DOI: https://doi.org/10.1007/s10384-011-0027-1

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