Skip to main content
Log in

Corneal morphogenesis during development and wound healing

  • Review
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Kao WW, Liu C-Y. The use of transgenic and knock-out mice in the investigation of ocular surface cell biology. Ocul Surf 2003;1:5–19.

    PubMed  Google Scholar 

  2. Kao WW, Xia Y, Liu CY, Saika S. Signaling pathways in morphogenesis of cornea and eyelid. Ocul Surf 2008;6:9–23.

    PubMed  Google Scholar 

  3. Cvekl A, Tamm ER. Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases. Bioessays 2004;26:374–386.

    Article  CAS  PubMed  Google Scholar 

  4. Tanifuji-Terai N, Terai K, Hayashi Y, Chikama T, Kao WW. Expression of keratin 12 and maturation of corneal epithelium during development and postnatal growth. Invest Ophthalmol Vis Sci 2006;47:545–551.

    Article  PubMed  Google Scholar 

  5. Liu CY, Zhu G, Converse RL, et al. Characterization and chromosomal localization of the cornea-specific murine keratin gene Krt1.12. J Biol Chem 1994;269:24627–24636.

    CAS  PubMed  Google Scholar 

  6. Liu CY, Shiraishi A, Kao CW, et al. The cloning of mouse keratocan cDNA and genomic DNA and the characterization of its expression during eye development. J Biol Chem 1998;273:22584–22588.

    Article  CAS  PubMed  Google Scholar 

  7. Byrne C, Tainsky M, Fuchs E. Programming gene expression in developing epidermis. Development 1994;120:2369–2383.

    CAS  PubMed  Google Scholar 

  8. Liu CY, Zhu G, Westerhausen-Larson A, et al. Cornea-specific expression of K12 keratin during mouse development. Curr Eye Res 1993;12:963–974.

    Article  CAS  PubMed  Google Scholar 

  9. Chikama T, Hayashi Y, Liu CY, et al. Characterization of tetracycline-inducible bitransgenic Krt12rtTA/+/tet-O-LacZ mice. Invest Ophthalmol Vis Sci 2005;46:1966–1972.

    Article  PubMed  Google Scholar 

  10. Hay ED, Zuk A. Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced. [Review]. Am J Kidney Dis 1995;26:678–690.

    Article  CAS  PubMed  Google Scholar 

  11. Hogan BL. Morphogenesis. Cell 1999;96:225–233.

    Article  CAS  PubMed  Google Scholar 

  12. Li DQ, Tseng SC. Differential regulation of keratinocyte growth factor and hepatocyte growth factor/scatter factor by different cytokines in human corneal and limbal fibroblasts. J Cell Physiol 1997;172:361–372.

    Article  CAS  PubMed  Google Scholar 

  13. Tuli SS, Liu R, Chen C, Blalock TD, Goldstein M, Schultz GS. Immunohistochemical localization of EGF, TGF-alpha, TGF-beta, and their receptors in rat corneas during healing of excimer laser ablation. Curr Eye Res 2006;31:709–719.

    Article  CAS  PubMed  Google Scholar 

  14. Carrington LM, Albon J, Anderson I, Kamma C, Boulton M. Differential regulation of key stages in early corneal wound healing by TGF-beta isoforms and their inhibitors. Invest Ophthalmol Vis Sci 2006;47:1886–1894.

    Article  PubMed  Google Scholar 

  15. Saika S, Ikeda K, Yamanaka O, et al. Loss of tumor necrosis factor alpha potentiates transforming growth factor beta-mediated pathogenic tissue response during wound healing. Am J Pathol 2006;168:1848–1860.

    Article  CAS  PubMed  Google Scholar 

  16. Saika S, Saika S, Liu CY, et al. TGFbeta2 in corneal morphogenesis during mouse embryonic development. Dev Biol 2001;240:419–432.

    Article  CAS  PubMed  Google Scholar 

  17. Xia Y, Kao WW. The signaling pathways in tissue morphogenesis: a lesson from mice with eye-open at birth phenotype. Biochem Pharmacol 2004;68:997–1001.

    Article  CAS  PubMed  Google Scholar 

  18. Berkowitz EA, Seroogy KB, Schroeder JA, et al. Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues. Cell Growth Differ 1996;7:1271–1282.

    CAS  PubMed  Google Scholar 

  19. Kao WW, Liu CY. The use of transgenic and knock-out mice in the investigation of ocular surface cell biology. Ocul Surf 2003;1:5–19.

    PubMed  Google Scholar 

  20. Saika S, Okada Y, Miyamoto T, et al. Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium. Invest Ophthalmol Vis Sci 2004;45:100–109.

    Article  PubMed  Google Scholar 

  21. Saika S, Ikeda K, Yamanaka O, et al. Expression of smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali. Am J Pathol 2005;166:1405–1418.

    CAS  PubMed  Google Scholar 

  22. Lovicu FJ, Kao WW, Overbeek PA. Ectopic gland induction by lens-specific expression of keratinocyte growth factor (FGF-7) in transgenic mice. Mech Dev 1999;88:43–53.

    Article  CAS  PubMed  Google Scholar 

  23. Chikama T, Liu CY, Meij JT, et al. Excess FGF-7 in corneal epithelium causes corneal intraepithelial neoplasia in young mice and epithelium hyperplasia in adult mice. Am J Pathol 2008;172:638–649.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Winston W.-Y. Kao.

About this article

Cite this article

Kao, W.WY., Liu, CY. Corneal morphogenesis during development and wound healing. Jpn J Ophthalmol 54, 206–210 (2010). https://doi.org/10.1007/s10384-010-0800-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-010-0800-6

Keywords

Navigation