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Assessing intraocular pressure by rebound tonometer in rats with an air-filled anterior chamber

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Abstract

Purpose

To compare rebound tonometer and cannulation as methods for measuring intraocular pressure (IOP) in rats.

Methods

The accuracy of the TonoLab rebound tonometer was determined in eight cannulated rat eyes. IOP was manipulated by changing air pressure from 20 to 100 mmHg at 10-mmHg intervals, and the IOP was measured with the rebound tonometer at each level. The average value of three repeated pressure readings was recorded. Correlation analysis and comparison with the Bland and Altman method were performed. The intraclass correlation coefficient was calculated to assess intraoperator variability.

Results

The IOP values measured with the TonoLab rebound tonometer were well correlated with the actual IOP (r 2 = 0.963, P = 0.01). The mean of the difference between the rebound tonometer and actual (cannulation) IOP was 7.41 ± 7.87%. The intraclass correlation coefficient was 0.9, indicating low intraoperator variability.

Conclusions

The rebound tonometer showed high accuracy and reliability for IOP measurement in rat eyes.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea

    Eun Ji Lee, Ki Ho Park, Dong Myung Kim, Young Cheol Yoo & Shin Hee Kang

  2. Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea

    Ki Ho Park, Dong Myung Kim, Young Cheol Yoo & Yu Jeong Kim

  3. Department of Ophthalmology, Gangdong Sacred Heart Hospital Hallym University College of Medicine, Seoul, Korea

    Young Cheol Yoo

  4. The Armed Forces Yangju Hospital, Yangju, Korea

    Shin Hee Kang

Authors
  1. Eun Ji Lee
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  2. Ki Ho Park
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  3. Dong Myung Kim
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  4. Young Cheol Yoo
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  5. Shin Hee Kang
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  6. Yu Jeong Kim
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Corresponding author

Correspondence to Ki Ho Park.

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Cite this article

Lee, E.J., Park, K.H., Kim, D.M. et al. Assessing intraocular pressure by rebound tonometer in rats with an air-filled anterior chamber. Jpn J Ophthalmol 52, 500–503 (2008). https://doi.org/10.1007/s10384-008-0591-1

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  • DOI: https://doi.org/10.1007/s10384-008-0591-1

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