Abstract
Background
Metastasis of mammary cancer involving the orbit is common, and it typically presents with enophthalmos and restrictions of ocular motility. We report a case of mammary cancer with the unusual presentation of unilateral periorbital edema only. The possible mechanisms of unilateral periorbital swelling are discussed.
Case
Metastasis of breast cancer involving unilateral eyelid edema was diagnosed in a 66-year-old woman. A biopsy was performed to confirm the etiology after vague neuroimaging findings. The diagnosis was based on the histopathologic features of carcinomatous cells in the excised specimen.
Observations
Insidious, progressive unilateral upper and lower eyelid swelling of the right eye disappeared after one cycle of palliative chemotherapy. Neither restriction nor proptosis developed in the whole course.
Conclusions
Possible metastasis should be considered as a possible etiology of unilateral eyelid edema, even without a palpable mass or limitation of ocular motility. A biopsy should be performed in cases of unexplained eyelid edema.
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References
Shields JA, Shields CL, Brotman HK, et al. Cancer metastatic to the orbit: the 2000 Robert M. Curts Lecture. Ophthal Plast Reconstr Surg 2001;17:346–354.
Toller KK, Gigantelli JW, Spalding MJ. Bilateral orbital metastases from breast carcinoma. A case of false pseudotumor. Ophthalmology 1998;105:1897–1901.
Kersten RC, Codère F, Dailey RA, et al. Basic and clinical science course section 7: orbit, eyelid and lacrimal system. San Francisco: American Academy of Ophthalmology; 2003–2004. p. 157.
Greene AK, Burrows PE, Smith L, et al. Periorbital lymphatic malformation: clinical course and management in 42 patients. Plast Reconstr Surg 2005;115:22–30.
Oh DE, Kim YD. Lymphoproliferative diseases of the ocular adnexa in Korea. Arch Ophthalmol 2007;125:1668–1673.
Bernardini FP. Bazzan M. Lymphoproliferative disease of the orbit. Curr Opin Ophthalmol 2007;18:398–401.
Cockerham KP, Hidayat AA, Cockerham GC, et al. Melkersson-Rosenthal syndrome: new clinicopathologic findings in 4 cases. Arch Ophthalmol 2000;118:227–232.
Shah P, Mishriki YY. The puffy periorbital protrusion. Pott’s puffy tumor. Postgrad Med 1999;105:45–46.
Wickremasinghe S, Dansingani KK, Tranos P, et al. Ocular presentations of breast cancer. Acta Ophthalmol Scand 2007;85:133–142.
Ettl A, Koornneef L, Daxer A, et al. High-resolution magnetic resonance imaging of the orbital connective tissue system. Ophthal Plast Reconstr Surg 1998;14:323–327.
Asproudis I, Gorezis S, Charalabopoulos K, et al. Breast carcinoma metastasis to the orbit and paranasal sinuses: a case report. Exp Oncol 2004;26:246–248.
Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol 1995;33:161–182; quiz 183–186.
Fahmy P, Heegaard S, Jensen OA, et al. Metastases in the ophthalmic region in Denmark 1969–98. A histopathological study. Acta Ophthalmol Scand 2003;81:47–50.
Reeves D, Levine MR, Lash R. Nonpalpable breast carcinoma presenting as orbital infiltration: case presentation and literature review. Ophthal Plast Reconstr Surg 2002;18:84–88.
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Kuo, SC., Hsiao, SC., Chiou, CC. et al. Metastatic carcinoma of the breast: A case with the unusual presentation of unilateral periorbital edema. Jpn J Ophthalmol 52, 305–307 (2008). https://doi.org/10.1007/s10384-008-0562-6
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DOI: https://doi.org/10.1007/s10384-008-0562-6