Indocyanine Green Angiography in a Case of Punctate Inner Choroidopathy Associated with Acute Zonal Occult Outer Retinopathy

Abstract

Background

The etiology of punctate inner choroidopathy (PIC) and acute zonal occult outer retinopathy (AZOOR) are currently unknown, although both diseases are hypothesized to be part of the spectrum of a single disorder.

Case

We report indocyanine green (ICG) angiographic findings in a 24-year-old woman in whom PIC was associated with AZOOR.

Observations

The patient had been diagnosed with bilateral PIC. She noticed a visual field defect in her right eye 8 months later, and a defect in her left eye 25 months later. Perimetry showed an arcuate scotoma (right eye) and a central scotoma (left eye), which could not be explained by funduscopy or late-phase fluorescein angiography. Multifocal electroretinography led to a diagnosis of bilateral AZOOR. ICG angiography demonstrated late multiple patchy hypofluorescent spots throughout the posterior pole in the right eye and geographic hypofluorescence in the macular region from initial to late phase in the left eye. However, these findings were not evident at the onset of PIC.

Conclusion

These angiographic results suggest that at the onset of AZOOR, choriocapillaris injuries had occurred in the areas corresponding to the scotomas. Jpn J Ophthalmol 2007;51:295–300 @ Japanese Ophthalmological Society 2007