Skip to main content

Changes of Oscillatory Potentials and Photopic Negative Response in Patients with Early Diabetic Retinopathy

Japanese Journal of Ophthalmology volume 50, pages 367–373 (2006)Cite this article

Abstract

Purpose

To investigate the clinical significance of the oscillatory potentials (OPs) and photopic negative response (PhNR) of the electroretinogram (ERG) in patients with early diabetic retinopathy.

Methods

One hundred two diabetic patients with diabetic retinopathy at different stages were examined. Thirty-two age-matched normal controls were also studied. Full-field maximal and photopic cone ERGs were recorded. The amplitudes and implicit times of the OPs, cone b wave, and PhNR were compared at the different stages of diabetic retinopathy.

Results

The a and b wave amplitudes of the maximal scotopic ERGs remained unchanged despite advancing stages of retinopathy, but the OP amplitudes were significantly attenuated even at an early stage of diabetic retinopathy. The amplitudes of both the PhNR and cone b wave were reduced at an early stage of diabetic retinopathy. Analysis of the receiver operating characteristic curves demonstrated that the amplitudes and implicit times of the OPs were more sensitive and specific than those of the PhNR in detecting changes of retinal function in the early stages of diabetic retinopathy.

Conclusions

The amplitudes of the OPs and PhNR progressively decrease with the progression of diabetic retinopathy. The PhNR amplitudes were reduced along with the cone b wave, indicating that earlier change of the PhNR in diabetic patients reflects reduced input to the retinal ganglion cell from the distal retina. The amplitudes and implicit times of the OPs are better indicators than those of the PhNR in detecting functional decreases in patients with early diabetic retinopathy. Jpn J Ophthalmol 2006;50:367–373 © Japanese Ophthalmological Society 2006

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

39,95 €

Price includes VAT (Finland)

References

  1. R Klein BEK Klein (1995) Diabetes in Americans National Institute of Health Bethesda, MD 293–338

    Google Scholar 

  2. D Yonemura K Tsuzuki T Aoki (1962) ArticleTitleClinical importance of the oscillatory potential in the human ERG Acta Ophthalmol (Copenh) Suppl 70 115–123 Occurrence Handle1:STN:280:DyaF383jt1Cmug%3D%3D Occurrence Handle10.1111/j.1755-3768.1962.tb00313.x

    Article  CAS  Google Scholar 

  3. D Yonemura T Aoki K Tsuzuki (1962) ArticleTitleElectroretinogram in diabetic retinopathy Arch Ophthalmol 68 19–24 Occurrence Handle14009176 Occurrence Handle1:STN:280:DyaF383gtFSqsA%3D%3D

    PubMed  CAS  Google Scholar 

  4. S Juen GF Kieselbach (1990) ArticleTitleElectrophysiological changes in juvenile diabetics without retinopathy Arch Ophthalmol 108 372–375 Occurrence Handle2310337 Occurrence Handle1:STN:280:DyaK3c7nvFGnug%3D%3D

    PubMed  CAS  Google Scholar 

  5. A Yoshida M Kojima H Ogasawara et al. (1991) ArticleTitleOscillatory potentials and permeability of the blood-retinal barrier in noninsulin-dependent diabetic patients without retinopathy Ophthalmology 98 1266–1271 Occurrence Handle1923365 Occurrence Handle1:STN:280:DyaK38%2FhvFKitw%3D%3D

    PubMed  CAS  Google Scholar 

  6. K Kawasaki (1998) ArticleTitlePreretinopathic changes in the oscillatory potential in diabetic retina: interpretation and significance Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc) 102 813–836 Occurrence Handle1:CAS:528:DyaK1MXht12lur8%3D

    CAS  Google Scholar 

  7. J Ambati KV Chalam DK Chawla et al. (1997) ArticleTitleElevated gamma-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy Arch Ophthalmol 115 1161–1166 Occurrence Handle9298058 Occurrence Handle1:STN:280:DyaK2svktlWqtQ%3D%3D

    PubMed  CAS  Google Scholar 

  8. E Lieth AJ Barber B Xu et al. (1998) ArticleTitleGlial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group Diabetes 47 815–820 Occurrence Handle9588455 Occurrence Handle1:CAS:528:DyaK1cXjs1Sgsbg%3D

    PubMed  CAS  Google Scholar 

  9. R Siliprandi R Canella G Carmignoto et al. (1992) ArticleTitleN-methyl-D-aspartate-induced neurotoxicity in the adult rat retina Vis Neurosci 8 567–573 Occurrence Handle1586655 Occurrence Handle1:STN:280:DyaK383msFOjsQ%3D%3D Occurrence Handle10.1017/S0952523800005666

    Article  PubMed  CAS  Google Scholar 

  10. Yamamoto H, Schmit-Kastner R, Hamasaki D, et al. Complex neurodegeneration in retina following chronic moderate ischemia induced by bilateral common carotid artery. Presented at the Association for Research in Vision and Ophthalmology meeting; 2 May 2005; Ft Lauderdale, FL, USA

  11. G Giovanni M Mascio V Matteo et al. (1998) ArticleTitleEffects of acute and repeated administration of amisulpride, a dopamine D2/D3 receptor antagonist, on the electrical activity of midbrain dopaminergic neurons J Pharmacol Exp Ther 287 51–57 Occurrence Handle9765321

    PubMed  Google Scholar 

  12. S Caputo MA Di Leo B Falsini et al. (1990) ArticleTitleEvidence for early impairment of macular function with pattern ERG in type I diabetic patients Diabetes Care 13 412–418 Occurrence Handle2318101 Occurrence Handle1:STN:280:DyaK3c3gtVOisQ%3D%3D

    PubMed  CAS  Google Scholar 

  13. S Viswanathan LJ Frishman JG Robson et al. (1999) ArticleTitleThe photopic negative response of the macaque electroretinogram: reduction by experimental glaucoma Invest Ophthalmol Vis Sci 40 1124–1136 Occurrence Handle10235545 Occurrence Handle1:STN:280:DyaK1M3kvFKhtg%3D%3D

    PubMed  CAS  Google Scholar 

  14. A Colotto B Falsini T Salgarello et al. (2000) ArticleTitlePhotopic negative response of the human ERG: losses associated with glaucomatous damage Invest Ophthalmol Vis Sci 41 2205–2211 Occurrence Handle10892864 Occurrence Handle1:STN:280:DC%2BD3czkvV2msQ%3D%3D

    PubMed  CAS  Google Scholar 

  15. S Viswanathan LJ Frishman JG Robson et al. (2001) ArticleTitleThe photopic negative response of the flash electroretinogram in primary open angle glaucoma Invest Ophthalmol Vis Sci 42 514–522 Occurrence Handle11157891 Occurrence Handle1:STN:280:DC%2BD3M7ktFKluw%3D%3D

    PubMed  CAS  Google Scholar 

  16. Y Gotoh S Machida Y Tazawa (2004) ArticleTitleSelective loss of the photopic negative response in patients with optic nerve atrophy Arch Ophthalmol 122 341–346 Occurrence Handle15006846 Occurrence Handle10.1001/archopht.122.3.341

    Article  PubMed  Google Scholar 

  17. NV Rangaswamy LJ Frishman EU Dorotheo et al. (2004) ArticleTitlePhotopic ERGs in patients with optic neuropathies: comparison with primate ERGs after pharmacologic blockade of inner retina Invest Ophthalmol Vis Sci 45 3827–3837 Occurrence Handle15452095 Occurrence Handle10.1167/iovs.04-0458

    Article  PubMed  Google Scholar 

  18. CP Wilkinson FL Ferris RE Klein et al. (2003) ArticleTitleProposed international diabetic retinopathy and diabetic macular edema disease severity scales Ophthalmology 101 1677–1682 Occurrence Handle10.1016/S0161-6420(03)00475-5

    Article  Google Scholar 

  19. M Kondo CH Piao A Tanikawa et al. (2001) ArticleTitleA contact lens electrode with built-in high intensity white light-emitting diodes. A contact lens electrode with built-in white LEDs Doc Ophthalmol 102 1–9 Occurrence Handle11475361 Occurrence Handle1:STN:280:DC%2BD38%2FisFyhtw%3D%3D Occurrence Handle10.1023/A:1017550507839

    Article  PubMed  CAS  Google Scholar 

  20. S Machida Y Gotoh M Tanaka et al. (2004) ArticleTitlePredominant loss of the photopic negative response in central retinal artery occlusion Am J Ophthalmol 137 938–940 Occurrence Handle15126164 Occurrence Handle10.1016/j.ajo.2003.10.023

    Article  PubMed  Google Scholar 

  21. H Sakai Y Tani E Shirasawa et al. (1995) ArticleTitleDevelopment of electro-retinographic alternations in streptozotocin-induced diabetes in rats Ophthalmic Res 27 57–63 Occurrence Handle7596561 Occurrence Handle1:STN:280:DyaK2MzhvFKlug%3D%3D

    PubMed  CAS  Google Scholar 

  22. HA Hancock TW Kraft (2004) ArticleTitleOscillatory potential analysis and ERGs of normal and diabetic rats Invest Ophthalmol Vis Sci 45 1002–1008 Occurrence Handle14985323 Occurrence Handle10.1167/iovs.03-1080

    Article  PubMed  Google Scholar 

  23. Y Shirao K Kawasaki (1998) ArticleTitleElectrical responses from diabetic retina Prog Retin Eye Res 17 59–76 Occurrence Handle9537795 Occurrence Handle1:STN:280:DyaK1c7nsl2jsw%3D%3D Occurrence Handle10.1016/S1350-9462(97)00005-0

    Article  PubMed  CAS  Google Scholar 

  24. AJ Barber E Leith SA Khin et al. (1998) ArticleTitleNeural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin J Clin Invest 102 783–791 Occurrence Handle9710447 Occurrence Handle1:CAS:528:DyaK1cXlsFaqsrg%3D Occurrence Handle10.1172/JCI2425

    Article  PubMed  CAS  Google Scholar 

  25. PM Martin P Roon TK Van Ells et al. (2004) ArticleTitleDeath of retinal neurons in streptozotocin-induced diabetic mice Invest Ophthalmol Vis Sci 45 3330–3336 Occurrence Handle15326158 Occurrence Handle10.1167/iovs.04-0247

    Article  PubMed  Google Scholar 

  26. GC Palmer GL Wilson RB Chronister (1983) ArticleTitleStreptozotocin-induced diabetes produces alterations in adenylate cyclase in rat cerebrum, cerebral microvessels and retina Life Sci 32 365–374 Occurrence Handle6131368 Occurrence Handle1:CAS:528:DyaL3sXltFCntg%3D%3D Occurrence Handle10.1016/0024-3205(83)90082-6

    Article  PubMed  CAS  Google Scholar 

  27. FK Northington RW Hamill SP Banerjee (1985) ArticleTitleDopamine-stimulated adenylate cyclase and tyrosine hydroxylase in diabetic rat retina Brain Res 337 151–154 Occurrence Handle2860952 Occurrence Handle1:CAS:528:DyaL2MXksFaitbg%3D Occurrence Handle10.1016/0006-8993(85)91621-X

    Article  PubMed  CAS  Google Scholar 

  28. C Nishimura K Kuriyama (1985) ArticleTitleAlterations in the retinal dopaminergic neuronal system in rats with streptozotocin-induced diabetes J Neurochem 45 448–455 Occurrence Handle3925083 Occurrence Handle1:CAS:528:DyaL2MXkvVGqtLg%3D

    PubMed  CAS  Google Scholar 

  29. CJ Gibson (1988) ArticleTitleDiurnal alternations in retinal tyrosine level and dopamine turnover in diabetic rats Brain Res 454 60–66 Occurrence Handle2900664 Occurrence Handle1:CAS:528:DyaL1cXkvFSltb4%3D Occurrence Handle10.1016/0006-8993(88)90803-7

    Article  PubMed  CAS  Google Scholar 

  30. Y Aizu K Oyanagi J Hu et al. (2002) ArticleTitleDegeneration of retinal neuronal processes and pigment epithelium in the early stage of the streptozotocin-diabetic rats Neuropathology 22 161–170 Occurrence Handle12416555 Occurrence Handle10.1046/j.1440-1789.2002.00439.x

    Article  PubMed  Google Scholar 

  31. HP Hammes J Lin O Renner et al. (2002) ArticleTitlePericytes and the pathogenesis of diabetic retinopathy Diabetes 51 3107–3112 Occurrence Handle12351455 Occurrence Handle1:CAS:528:DC%2BD38XnslGhsbw%3D

    PubMed  CAS  Google Scholar 

  32. V Asnaghi C Gerhardinger T Hoehn et al. (2003) ArticleTitleA role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat Diabetes 52 506–511 Occurrence Handle12540628 Occurrence Handle1:CAS:528:DC%2BD3sXhtFansLc%3D

    PubMed  CAS  Google Scholar 

  33. YS Kim YH Kim EW Cheon et al. (2003) ArticleTitleRetinal expression of clusterin in the streptozotocin-induced diabetic rat Brain Res 20 IssueID976 53–59 Occurrence Handle10.1016/S0006-8993(03)02636-2 Occurrence Handle1:CAS:528:DC%2BD3sXjvV2lsro%3D

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Iwate Medical University School of Medicine, Morioka, Iwate, Japan

    Junya Kizawa, Shigeki Machida, Takaki Kobayashi, Yasutaka Gotoh & Daijiro Kurosaka

Authors
  1. Junya Kizawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shigeki Machida
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takaki Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yasutaka Gotoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Daijiro Kurosaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shigeki Machida.

About this article

Cite this article

Kizawa, J., Machida, S., Kobayashi, T. et al. Changes of Oscillatory Potentials and Photopic Negative Response in Patients with Early Diabetic Retinopathy. Jpn J Ophthalmol 50, 367–373 (2006). https://doi.org/10.1007/s10384-006-0326-0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-006-0326-0

Key words

  • diabetic retinopathy
  • electroretinogram
  • oscillatory potentials
  • photopic negative response