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Time-Dependent Course of Electroretinograms in the Spontaneous Diabetic Goto-Kakizaki Rat

Japanese Journal of Ophthalmology volume 50, pages 211–216 (2006)Cite this article

Abstract

Purpose

This study evaluates the relevance to human retinopathy of electroretinograms (ERGs) from the spontaneously diabetic Goto-Kakizaki (GK) rat.

Methods

Starting from 4 weeks of age, we obtained ERGs every 4 weeks from six GK rats and seven Wistar (control) rats, and from two GK and two Wistar rats at 14 days of age. The a-wave, b-wave, and oscillatory potentials (OPs) were recorded after stimulation with a single bright flash. We compared the amplitudes and implicit times and measured a-wave latencies to evaluate photoreceptor function.

Results

The amplitudes of the a-wave, b-wave, and OPs (O1 and O2) of the GK rats were reduced between 4 and 48 weeks of age. The time-dependent courses of change in a-wave, b-wave, and O2 amplitude did not differ between the two groups. The a-wave latencies in GK rats were significantly prolonged, but not the implicit times of OPs. At 14 days of age, the a-wave amplitudes were significantly smaller in GK than in Wistar rats.

Conclusion

Functional abnormalities of photoreceptors might be induced by inheritable degeneration at an early age in the GK rat. Although hyperglycemia would cause retinal hypoxia, it would not be severe enough to disturb the generation of OPs. Jpn J Ophthalmol 2006;50:211–216 © Japanese Ophthalmological Society 2006

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Authors and Affiliations

  1. Department of Ophthalmology, Mie University School of Medicine, Tsu, Mie, Japan

    Hisashi Matsubara, Manami Kuze, Mikio Sasoh, Motoyasu Furuta & Yukitaka Uji

  2. Department of Anatomy, Mie University School of Medicine, Tsu, Mie, Japan

    Ning Ma

Authors
  1. Hisashi Matsubara
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  2. Manami Kuze
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  3. Mikio Sasoh
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  4. Ning Ma
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  5. Motoyasu Furuta
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  6. Yukitaka Uji
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Corresponding author

Correspondence to Hisashi Matsubara.

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Matsubara, H., Kuze, M., Sasoh, M. et al. Time-Dependent Course of Electroretinograms in the Spontaneous Diabetic Goto-Kakizaki Rat. Jpn J Ophthalmol 50, 211–216 (2006). https://doi.org/10.1007/s10384-005-0315-8

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  • DOI: https://doi.org/10.1007/s10384-005-0315-8

Key words

  • electroretinogram
  • Goto-Kakizaki rat
  • spontaneously diabetic rat