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Tracing Method in the Assessment of Retinal Capillary Blood Flow Velocity by Fluorescein Angiography with Scanning Laser Ophthalmoscope

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Abstract

Purpose

To evaluate the feasibility of a new method (the tracing method) for measuring perifoveal capillary blood flow velocity (BFV).

Methods

The BFV in the perifoveal capillaries was measured in 12 eyes of healthy subjects and 12 eyes of patients with clinically significant macular edema (CSME) by fluorescein angiography using a scanning laser ophthalmoscope by either the tracing method or the conventional method. A randomized crossover design was employed to assign the subjects to each method.

Results

The number of capillaries recognized by the tracing method in healthy subjects and in patients with CSME was significantly higher than that recognized with the conventional method (P = 0.0134 and P = 0.0108, respectively). The number of fluorescent dots detected by the tracing method in healthy subjects and in patients with CSME was also significantly higher than that detected with the conventional method (P = 0.0002 and P = 0.0137, respectively). Accurate detection of the movement of fluorescent dots and analysis of BFV were possible with the tracing method. The BFV varied within each perifoveal capillary, and the mean BFV also varied according to capillary location in the macula.

Conclusion

The new tracing method is useful for analyzing the retinal capillary BFV in healthy subjects and in patients with CSME. Jpn J Ophthalmol 2006;50:25–32 © Japanese Ophthalmological Society 2006

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Authors and Affiliations

  1. Department of Ophthalmology, Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan

    Hideharu Funatsu

  2. Department of Ophthalmology, Tokyo Women's Medical University, Tokyo, Japan

    Kumi Sakata & Sadao Hori

  3. Department of Ophthalmology, Yodogawa Christian Hospital, Osaka, Japan

    Seiyo Harino

  4. Well System Company, Tokyo, Japan

    Yukio Okuzawa

  5. Department of Ophthalmology and Visual Science, Hiroshima University School of Medicine, Hiroshima, Japan

    Hidetaka Noma

Authors
  1. Hideharu Funatsu
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  2. Kumi Sakata
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  3. Seiyo Harino
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  4. Yukio Okuzawa
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  5. Hidetaka Noma
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  6. Sadao Hori
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Corresponding author

Correspondence to Hideharu Funatsu.

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Funatsu, H., Sakata, K., Harino, S. et al. Tracing Method in the Assessment of Retinal Capillary Blood Flow Velocity by Fluorescein Angiography with Scanning Laser Ophthalmoscope. Jpn J Ophthalmol 50, 25–32 (2006). https://doi.org/10.1007/s10384-005-0266-0

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  • DOI: https://doi.org/10.1007/s10384-005-0266-0

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