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Unique characteristics of two types of retinitis pigmentosa patients with different rod sensitivities

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Abstract

Purpose

To determine the psychophysical differences between two types of retinitis pigmentosa (RP) patients with different rod sensitivities.

Methods

Thirty-five RP patients with a visual acuity of ≥0.7 or better were classified by cone–rod perimetry into type 1, those with undetectable rod sensitivity, and type 2, those with measurable rod sensitivity. Their symptoms, age at onset of symptoms, cone and rod sensitivity, and full-field electroretinograms (ERGs) were compared.

Results

The age when the symptoms of night blindness were first noticed was 13.1 ± 3.3 years (mean ± SD) for type 1 and 34.5 ± 14.4 years for type 2 patients (P = 0.0001). One of nine type 1 patients (11%) and 10 of 26 type 2 patients (38%) did not have any symptoms of night blindness. The average rod sensitivity within the central 10° was 43.7 ± 12.0 dB for type 2 patients with night blindness, and 54.8 ± 6.4 dB for type 2 patients without night blindness (P = 0.014). One of nine (11%) type 1 patients and 9 of 23 (39%) type 2 patients had recordable ERGs (P = 0.13).

Conclusions

These findings indicate that the two types of RP patients, distinguished by their rod sensitivity, have different psychophysical characteristics of the visual system. The course of the disease process and the long-term prognosis for these two types of patients are different.

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Correspondence to Hiroaki Takahashi.

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Takahashi, H., Miyake, Y., Horiguchi, M. et al. Unique characteristics of two types of retinitis pigmentosa patients with different rod sensitivities. Jpn J Ophthalmol 49, 114–120 (2005). https://doi.org/10.1007/s10384-004-0160-1

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Key Words

  • cone–rod perimetry
  • night blindness
  • retinitis pigmentosa
  • rod sensitivity