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Effect of suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, on acute eosinophilic myocarditis: a case report

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Abstract

 We encountered a 44-year-old woman with acute eosinophilic myocarditis that showed positive immunostaining for interleukin-4 in the area of marked infiltration of eosinophils into the myocardium. When prednisolone alone proved ineffective, supplementary treatment with suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, improved the patient's inflammation, reduced the level of cardiac enzymes, and allowed for a reduction in corticosteroid dosage without any adverse effects.

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Authors and Affiliations

  1. Pharmaceutical Clinical Research Center, Yamaguchi University Hospital, 1-1-1 Minami Kogushi, Ube, Yamaguchi 755-8505, Japan, , , , , , JP

    Seiji Umemoto

  2. Department of Cardiovascular Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan, , , , , , JP

    Kazuo Itagaki, Masahiro Kimura, Shinichi Itoh, Masakazu Tanaka, Masahiko Haraguchi & Masunori Matsuzaki

Authors
  1. Seiji Umemoto
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  2. Kazuo Itagaki
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  3. Masahiro Kimura
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  4. Shinichi Itoh
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  5. Masakazu Tanaka
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  6. Masahiko Haraguchi
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  7. Masunori Matsuzaki
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Received: July 10, 2002 / Accepted: October 6, 2002

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Umemoto, S., Itagaki, K., Kimura, M. et al. Effect of suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, on acute eosinophilic myocarditis: a case report. Heart Vessels 18, 100–102 (2003). https://doi.org/10.1007/s10380-002-0689-2

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  • DOI: https://doi.org/10.1007/s10380-002-0689-2

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