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Malignant melanoma in a patient with hidrotic ectodermal dysplasia

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  1. Parhizkar N, Jones V, McClay E, et al. Metastatic melanoma in a patient with Clouston syndrome successfully treated with isolated hyperthermic limb perfusion (with melphalan). J Cutan Med Surg. 2003;7(1):43–6.

    Article  Google Scholar 

  2. Gregoriou S, Rigopoulus D, Vergou T, et al. Should we consider hypohidrotic ectodermal dysplasia as a possible risk factor for malignant melanoma? J Cutan Med Surg. 2007;11(5):188–90.

    Article  Google Scholar 

  3. Kasmann B, Ruprecht K. Ocular manifestations in a father and son with EEC syndrome. Graefes Arch Clin Exp Ophthalmol. 1997;235(8):512–6.

    CAS  Article  Google Scholar 

  4. Taylor T, Hayflick S, McKinnon W, et al. Confirmation of linkage of Clouston syndrome (hidrotic ectodermal dysplasia) to 13q11–q12.1 with evidence for multiple independent mutations. J Invest Dermatol. 1998;111(1):83–5.

    CAS  Article  Google Scholar 

  5. Fountain JW. Genetic factors. In: Balch CM, editor. Cutaneous melanoma. Vol. 3. St. Louis, MO: Quality Medical Publ; 1998. pp. 475–92.

    Google Scholar 

  6. Montonen O, Ezer S, Laurikkala J, et al. Expression of the anhidrotic ectodermal dysplasia gene is reduced in skin cancer coinciding with reduced E‑cadherin. Exp Dermatol. 1998;7(4):168–74.

    CAS  Article  Google Scholar 

  7. Kaskel P, Kind P, Sander S, et al. Trauma and melanoma formation: a true association? Br J Dermatol. 2000;143(4):749–53.

    CAS  Article  Google Scholar 

  8. Dessureault J, Poulin Y, Bourcier M, Gagne E. Olmsted syndrome-palmoplantar and periorificial keratodermas: association with malignant melanoma. J Cutan Med Surg. 2003;7(3):236–42.

    Article  Google Scholar 

  9. Rubegni P, Poggiali S, Cuccia A, et al. Acral malignant melanoma and striated palmoplantar keratoderma (Brunauer-Fohs-Siemens syndrome): a fortuitous association? Dermatol Surg. 2004;30(12 Pt 2):1539–42.

    PubMed  Google Scholar 

  10. Mozzillo N, Nunziata CA, Caraco C, et al. Melanoma Cooperative Group.Malignant melanoma developing in an area of hereditary palmoplantar keratoderma (Mal de Meleda). J Surg Oncol. 2003;84(4):229–33.

    Article  Google Scholar 

  11. Otley C, Stasko T, Tope WD, Lebwohl M. Chemoprevention of nonmelanoma skin cancer with systemic retinoids: practical dosing and management of adverse effects. Dermatol Surg. 2006;32(4):562–8.

    CAS  PubMed  Google Scholar 

  12. Huntington YH (2003). The role of AP‑1 transcription complex in retinoic acid-dependent B16 melanoma cell growth arrest and differentiation. Dissertation, Huntington, West Virginia,

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Correspondence to Hristo Petrov Dobrev MD, DMSc.

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H.P. Dobrev, T.I. Abadjieva, T.I. Aleksiev, Z.G. Ivanova, and N.I. Vutova declare that they have no competing interests.

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Consent: The examination of the patients was conducted according to the Declaration of Helsinki principles.

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Dobrev, H.P., Abadjieva, T.I., Aleksiev, T.I. et al. Malignant melanoma in a patient with hidrotic ectodermal dysplasia. Wien Med Wochenschr (2022).

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