Summary
Aim
The aim of this study was to explore the psychiatric comorbidities in cancer patients examined by the psychiatric consultation liaison services (CLP) in a general hospital. Furthermore, we intended to examine associations between certain cancers types and psychiatric disorders as well as to give an overview of the psychiatric treatments options that were recommended by the CLP.
Methods
This retrospective analysis investigated 119 psychiatric consultations for cancer patients in a one year period. The assessment covered demographics and cancer diagnosis, psychiatric diagnosis and proceedings.
Results
One third of all patients were treated for hematological cancer, followed by lung cancer. Depression was the most common psychiatric disorder. One third of all patients with hematological cancer were diagnosed with depression, followed by delirium. Inpatient psychiatric treatment and psychotherapy were most commonly recommended by the consultant psychiatrist. Furthermore, 80.2% of all patients received recommendations for medication with antidepressants.
Conclusion
Our data showed that the CLP provides an important service of detecting and initiating early and appropriate treatment for cancer patients with comorbid psychiatric disorders by directing patients to the relevant treatment procedure or facility.
Similar content being viewed by others
References
Ostuzzi G, Benda L, Costa E, et al. Efficacy and acceptability of antidepressants on the continuum of depressive experiences in patients with cancer: systematic review and meta-analysis. Cancer Treat Rev. 2015;41(8):714–24.
Ostuzzi G, Matcham F, Dauchy S, et al. Antidepressants for the treatment of depression in people with cancer. Cochrane Database Syst Rev. 2018;4:CD11006.
Mehnert A, Brähler E, Faller H, et al. Four-week prevalence of mental disorders in patients with cancer across major tumor entities. J Clin Oncol. 2014;32(31):3540–6.
Krebber AM, Buffart LM, Kleijn G, et al. Prevalence of depression in cancer patients: a meta-analysis of diagnostic interviews and self-report instruments. Psychooncology. 2014;23(2):121–30.
Boyes AW, Girgis A, D’Este C, et al. Flourishing or floundering? Prevalence and correlates of anxiety and depression among a population-based sample of adult cancer survivors 6 months after diagnosis. J Affect Disord. 2011;135(1–3):184–92.
Grassi L, Caruso R, Hammelef K, et al. Efficacy and safety of pharmacotherapy in cancer-related psychiatric disorders across the trajectory of cancer care: a review. Int Rev Psychiatry. 2014;26(1):44–62.
Niedzwiedz CL, Knifton L, Robb KA, Katikireddi SV, Smith DJ. Depression and anxiety among people living with and beyond cancer: a growing clinical and research priority. BMC Cancer. 2019;19(1):943. https://doi.org/10.1186/s12885-019-6181-4.
Mausbach BT, Schwab RB, Irwin SA. Depression as a predictor of adherence to adjuvant endocrine therapy (AET) in women with breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat. 2015;152(2):239–46.
Singer S, Das-Munshi J, Brähler E. Prevalence of mental health conditions in cancer patients in acute care—a meta-analysis. Ann Oncol. 2010;21:925–30.
LeGrand SB. Delirium in palliative medicine: a review. J Pain Symptom Manage. 2012;44:583–94.
Miovic M, Block S. Psychiatric disorders in advanced cancer. Cancer. 2007;110:1665–76.
Mehta RD, Roth AJ. Psychiatric considerations in the oncology setting. CA Cancer J Clin. 2015;65:299–314.
Colleoni M, Mandala M, Peruzzotti G, et al. Depression and degree of acceptance of adjuvant cytotoxic drugs. Lancet. 2000;356(9238):1326–7.
Arrieta O, Angulo LP, Núñez-Valencia C, et al. Association of depression and anxiety on quality of life, treatment adherence, and prognosis in patients with advanced non-small cell lung cancer. Ann Surg Oncol. 2013;20(6):1941–8.
Prieto JM, Blanch J, Atala J, et al. Psychiatric morbidity and impact on hospital length of stay among hematologic cancer patients receiving stemcell transplantation. J Clin Oncol. 2002;20(7):1907–17.
Lloyd-Williams M, Shiels C, Taylor F, et al. Depression—an independent predictor of early death inpatients with advanced cancer. J Affect Disord. 2009;113:127–32.
Pinquart M, Duberstein PR. Depression and cancer mortality: a meta-analysis. Psychol Med. 2010;40(11):1797–810.
Satin JR, Linden W, Phillips MJ. Depression as a predictor of disease progression and mortality in cancer patients. A meta-analysis. Cancer. 2009;22:5349–61.
Brenne E, Loge JH, Kaasa S, et al. Depressed patients with incurable cancer: which depressive symptoms do they experience? Palliat Support Care. 2013;11(6):491–500.
Onitilo AA, Nietert PJ, Egede LE. Effect of depression on all-cause mortality in adults with cancer and differential effects by cancer site. Gen Hosp Psychiatry. 2006;28:396–402.
Shim EJ, Park JH. Suicidality and its associated factors in cancer patients: results of a multi-center study in Korea. Int J Psychiatry Med. 2012;43(4):381–403.
Zhou H, Xian W, Zhang Y, Yang Y, Fang W, Liu J, et al. Suicide among cancer patients: adolescents and young adult (AYA) versus all-age patients. Ann Transl Med. 2019;7(22):658.
Oberaigner W, Sperner-Unterweger B, Fiegl M, et al. Increased suicide risk in cancer patients in Tyrol/Austria. Gen Hosp Psychiatry. 2014;36:483–7.
Derogatis LR, Morrow GR, Fetting J, et al. The prevalence of psychiatric disorders among cancer patients. JAMA. 1983;249:751–7.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Washington D.C.: American Psychiatric Press; 2000.
IBM Corp. IBM SPSS statistics for Windows, version 21.0. Armonk, NY: IBM Corp; 2012.
Linden W, Vodermaier A, Mackenzie R, et al. Anxiety and depression after cancer diagnosis: prevalence rates by cancer type, gender, and age. J Affect Disord. 2012;141(2–3):343–51.
Lu D, Andrae B, Valdimarsdóttir U, Sundström K, Fall K, Sparén P, et al. Psychological distress is associated with cancer-specific mortality among patients with cervical cancer. Cancer Res. 2019;28:canres.0116.2019.
Fissler M, Quante A. Psychiatric liaison consultations of patients without psychiatric illness in a general hospital in Germany: a retrospective analysis. Wien Med Wochenschr. 2015;165(21–22):436–44. https://doi.org/10.1007/s10354-015-0384-3.
El Majzoub I, Abunafeesa H, Cheaito R, Cheaito MA, Elsayem AF. Management of altered mental status and delirium in cancer patients. Ann Palliat Med. 2019;8(5):728–39. https://doi.org/10.21037/apm.2019.09.14.
Akechi A, Nakano T, Okamura H, et al. Psychiatric disorders in cancer patients: descriptive analysis of 1721 psychiatric referrals at two Japanese cancer center hospitals. Jpn J Clin Oncol. 2001;31(5):188–94.
Andersen BL, Yang HC, Farrar WB, et al. Psychologic intervention improves survival for breast cancer patients: a randomized clinical trial. Cancer. 2008;113:413–20.
Giese-Davis J, Collie K, Rancourt KM, et al. Decrease in depression symptoms in associated with longer survival in patients with metastatic breast cancer: a secondary analysis. J Clin Oncol. 2011;29:413–20.
Sharpe M, Walker J, Holm Hansen C, SMaRT (Symptom Management Research Trials) Oncology‑2 Team, et al. Integrated collaborative care for comorbid major depression in patients with cancer (SMaRT Oncology-2): a multicentre randomised controlled effectiveness trial. Lancet. 2014;384(9948):1099–108.
Zahid JA, Grummedal O, Madsen MT, Gögenur I. Prevention of depression in patients with cancer: a systematic review and meta-analysis of randomized controlled trials. J Psychiatr Res. 2020;120:113–23.
Li M, Fitzgerald P, Rodin G. Evidence-based treatment of depression in patients with cancer. J Clin Oncol. 2012;30(11):1187–96.
Miguel C, Albuquerque E. Drug interaction in psycho-oncology: antidepressants and antineoplastics. Pharmacology. 2011;88:333–9.
Laoutidis ZG, Mathiak K. Antidepressants in the treatment of depression/depressive symptoms in cancer patients: a systematic review and meta-analysis. BMC Psychiatry. 2013;13(140):1–21.
Rayner L, Price A, Evans A, et al. Antidepressants for depression in physically ill people. Cochrane Database Syst Rev. 2010;3:CD750.
Rayner L, Price A, Evans A, et al. Antidepressants for the treatment of depression in palliative care: systematic review and meta-analysis. Palliat Med. 2011;25(1):36–51.
Michelini S, Cassano GB, Frare F, et al. Long-term use of benzodiazepines: tolerance, dependence and clinical problems in anxiety and mood disorders. Pharmacopsychiatry. 1996;29:127–34.
Salzman C. The benzodiazepine controversy: therapeutic effects versus dependence, withdrawal and toxicity. Harv Rev Psychiatry. 1997;4:279–82.
Ogawa Y, Takeshima N, Hayasaka Y, Tajika A, Watanabe N, Streiner D, et al. Antidepressants plus benzodiazepines for adults with major depression. Cochrane Database Syst Rev. 2019;6:CD1026.
Bonnet U, Richter EL, Isbruch K, Scherbaum N. On the addictive power of gabapentinoids: a mini-review. Psychiatr Danub. 2018;30(2):142–9.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
A. Quante, K. Schulz, and M. Fissler declare that they have no competing interests.
Ethical standards
Approval by the local ethics committee (Berlin Ethics Committee) was not needed.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Author contributions
All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Kristina Schulz and Arnim Quante. The first draft of the manuscript was written by Kristina Schulz and Maria Fissler. The conceptualization and methodology was performed by Arnim Quante. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
Rights and permissions
About this article
Cite this article
Quante, A., Schulz, K. & Fissler, M. Psychiatric comorbidities in cancer patients: acute interventions by the psychiatric consultation liaison service. Wien Med Wochenschr 170, 348–356 (2020). https://doi.org/10.1007/s10354-020-00739-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10354-020-00739-0