Zusammenfassung
Der Goldstandard zur effektiven Schmerztherapie während der Geburt stellt die Regionalanalgesie mittels Periduralanalgesie (PDA) dar. Hierbei ist eine intermittierende epidurale Bolusgabe (PIEB) einer kontinuierlichen Applikation des Schmerzmittels hinsichtlich einer besseren Schmerzreduktion, weniger motorischer Blockaden und einer höheren Zufriedenheit der Gebärenden überlegen. Als Alternative zur rückenmarksnahen Nervenblockade bietet sich Remifentanil an, ein Opioid mit kurzer kontextsensitiver Halbwertszeit und somit kurzer Wirkdauer. Die Anwendung sollte aufgrund einer möglichen kardiopulmonalen Depression unter kontinuierlichem Herz-Kreislauf-Monitoring erfolgen. Lachgas wird in englischsprachigen Ländern seit Jahrzehnten angewendet. Allerdings ist Lachgas ein Treibhausgas, und es kann mit Vitamin B12 interagieren. Im deutschsprachigen Raum erfährt Lachgas eine Renaissance zur Therapie von Geburtsschmerzen. Es kann insbesondere zur kurzfristigen Reduktion von Geburtsschmerzen eingesetzt werden. Um der Gebärenden die bestmögliche Schmerztherapie während der Geburt anbieten zu können, sollte ihr in einem multidisziplinären Ansatz mit Geburtshelfern, Hebammen und Anästhesisten frühzeitig ein individuelles Konzept angeboten werden.
Summary
To date the gold standard of treating labour pain is regional analgesia by application of epidural analgesia. When offering epidural analgesia, the programmed intermittent epidural bolus (PIEB) is more effective in terms of pain reduction, less motor blocks and higher satisfaction of the parturient compared to continuous application via perfusor pump. An upcoming alternative to epidural analgesia is remifentanil, a short acting and potent opioid. Remifentanil, however, requires haemodynamic monitoring as cardiac and respiratory impairment has been described. Nitrous oxide has been used for decades in the Anglosphere but it is a greenhouse gas, and interactions with Vitamin B12 are possible. Using novel extraction systems, nitrous oxide has become more attractive for treatment of the initial phase of labour pain in Central Europe. In order to provide the parturient with the best possible and with a tailored pain concept an interdisciplinary approach with obstetricians, midwives and anaesthesiologists is required.
Literatur
Hiltunen P, Raudaskoski T, Ebeling H, et al. Does pain relief during delivery decrease the risk of postnatal depression? Acta Obstet Gynecol Scand. 2004;83(3):257–61.
Soet JE, Brack GA, DiIorio C. Prevalence and predictors of women’s experience of psychological trauma during childbirth. Birth. 2003;30(1):36–46.
Schneider H, Husslein PW, Schneider K‑TM. Die Geburtshilfe. Heidelberg: Springer; 2006.
Hawkings JL. Epidural analgesia for labor and delivery. N Eng J Med. 2010;362:1503–10.
Craß D, Friedrich J. Die Epiduralanalgesie zur Geburtshilfe. Anaesthesist. 2003;52:727–46.
Seyb ST, Berka RJ, Socol ML, et al. Risk of cesarean delivery with elective induction of labor at term in nulliparous women. Obstet Gynecol. 1999;94(4):600–7.
Liu EH, Sia AT. Rates of caesarean section and instrumental vaginal delivery in nulliparous women after low concentration epidural infusions or opioid analgesia: systematic review. BMJ. 2004;328(7453):1410.
Halpern SH, Muir H, Breen TW, et al. A multicenter randomized controlled trial comparing patient-controlled epidural with intravenous analgesia for pain relief in labor. Anesth Analg. 2004;99(5):1532–8.
Wong CA, Scavone BM, Peaceman AM, et al. The risk of cesarean delivery with neuraxial analgesia given early versus late in labor. N Engl J Med. 2005;352(7):655–65.
Hu LQ, Zhang J, Wong CA, et al. Impact of the introduction of neuraxial labor analgesia on mode of delivery at an urban maternity hospital in China. Int J Gynaecol Obstet. 2015;129(1):17–21.
Wang F, Shen X, Guo X, et al. Epidural analgesia in the latent phase of labor and the risk of cesarean delivery: a five-year randomized controlled trial. Anesthesiology. 2009;111(4):871–80.
Wassen MM, Hukkelhoven CW, Scheepers HC, et al. Epidural analgesia and operative delivery: a ten-year population-based cohort study in the Netherlands. Eur J Obstet Gynecol Reprod Biol. 2014;183:125–31.
Loewenberg-Weisband Y, Grisaru-Granovsky S, Ioscovich A, et al. Epidural analgesia and severe perineal tears: a literature review and large cohort study. J Matern Fetal Neonatal Med. 2014;27:1864–9.
Jangö H, Langhoff-Roos J, Rosthøj S, et al. Modifiable risk factors of obstetric anal sphincter injury in primiparous women: a population-based cohort study. Am J Obstet Gynecol. 2014;210(1):59.e1–59.e6.
Freeman LM, Bloemenkamp KW, Franssen MT, et al. Patient controlled analgesia with remifentanil versus epidural analgesia in labour: randomised multicentre equivalence trial. BMJ. 2015;350:h846.
Logtenberg SLM, Oude Rengerink K, Verhoeven CJ, et al. Labour pain with remifentanil patient-controlled analgesia versus epidural analgesia: a randomised equivalence trial. BJOG. 2016;124(4):652–60. doi:10.1111/1471-0528.14181.
George RB, Allen TK, Habib AS. Intermittent epidural bolus compared with continuous epidural infusion for labor analgesia: a systematic review and meta-analysis. Anesth Analg. 2013;116(1):133–44.
Sia AT, Leo S, Ocampo CE. A randomised comparison of variable-frequency automated mandatory boluses with a basal infusion for patient-controlled epidural analgesia during labour and delivery. Anaesthesia. 2013;68(3):267–75.
Capogna G, Stirparo S. Techniques for the maintenance of epidural labor analgesia. Curr Opin Anaesthesiol. 2013;26(3):261–7.
Capogna G, Camorcia M, Stirparo S, et al. Programmed intermittent epidural bolus versus continuous epidural infusion for labor analgesia: the effects on maternal motor function and labor outcome. A randomized double-blind study in in nulliparous women. Anesth Analg. 2011;113(4):826–31.
Schnabel A, Hahn N, Muellenbach R, et al. Obstetric analgesia in German clinics. Remifentanil as alternative to regional analgesia. Anaesthesist. 2011;60(11):995–1001.
Bonner JC, McClymont W. Respiratory arrest in an obstetric patient using remifentanil patient-controlled analgesia. Anaesthesia. 2012;67(5):538–40.
Marr R, Hyams J, Bythell V. Cardiac arrest in an obstetric patient using remifentanil patient-controlled analgesia. Anaesthesia. 2013;68(3):283–7.
Volmanen P, Akural E, Raudaskoski T, et al. Comparison of remifentanil and nitrous oxide in labour analgesia. Acta Anaesthesiol Scand. 2005;49(4):453–8, Apr.
Liu ZQ, Chen XB, Li HB, et al. A comparison of remifentanil parturient-controlled intravenous analgesia with epidural analgesia: a meta-analysis of randomized controlled trials. Anesth Analg. 2014;118:598–603.
Heck M, Fresenius M. Repetitorium Anaesthesiologie. Heidelberg: Springer; 2001.
Rosen MA. Nitrous oxide for relief of labor pain: a systematic review. Am J Obstet Gynecol. 2002;186(5 Suppl):S110–S126.
Klomp T, van Poppel M, Jones L, et al. Inhaled analgesia for pain management in labour. Cochrane Database Syst Rev. 2012. doi:10.1002/14651858.cd009351.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
S. Jochberger erhielt im Juli 2015 von der Firma Smiths Medical ein Honorar im Rahmen einer Pressekonferenz. C. Ortner und K.U. Klein geben an, dass kein Interessenkonflikt besteht.
Rights and permissions
About this article
Cite this article
Jochberger, S., Ortner, C. & Klein, K.U. Schmerztherapie während der Geburt. Wien Med Wochenschr 167, 368–373 (2017). https://doi.org/10.1007/s10354-017-0571-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10354-017-0571-5