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The history of Botulinum toxin: from poison to beauty

Summary

Botulinum toxin, also called the “miracle toxin,” is a neurotoxin produced by the bacteria Clostridium botulinum. It is known to block nerve signals that contract muscles resulting in a temporary paralysis of the muscles. Toxins type A and B have been extensively studied and utilized in the realm of beauty and cosmetology. Initially, the toxin gained popularity as a disease-causing “poison”. It was only later that it found its way to becoming a must have in modern aesthetic practice. Today, this wonder toxin has proven to be an apt and convenient option in the field of anti-aging medicine.

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References

  1. Nigam PK, Nigam A. Botulinum toxin. Indian J Dermatol. 2010;55:8–14.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  2. Satila H. The route of botulinum toxin from cause of food poisoning to medical remedy. Duodecim. 2014;130:1523–30.

    PubMed  Google Scholar 

  3. Erbguth FJ, Naumann M. Historical aspects of botulinum toxin: Justinus Kerner (1786–1862) and the “sausage poison”. Neurology. 1999;53:1850–3.

    CAS  Article  PubMed  Google Scholar 

  4. Erbguth FJ. Historical notes on botulism, clostridium botulinum, botulinum toxin, and the idea of the therapeutic use of the toxin. Mov Disord. 2004;19(8):S2–S6.

    Article  PubMed  Google Scholar 

  5. Erbguth FJ. From poison to remedy: the chequered history of botulinum toxin. J Neural Transm (Vienna). 2008;115:559–65.

    CAS  Article  Google Scholar 

  6. Lamanna C, Mc EO, Eklund HW. The purification and crystallization of Clostridium botulinum type A toxin. Science. 1946;103:613.

    CAS  Article  Google Scholar 

  7. Small R. Botulinum toxin injection for facial wrinkles. Am Fam Physician. 2014;90:168–75.

    PubMed  Google Scholar 

  8. Loyo M, Kontis TC. Cosmetic botulinum toxin: has it replaced more invasive facial procedures? Facial Plast Surg Clin North Am. 2013;21:285–98.

    Article  PubMed  Google Scholar 

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Correspondence to Katlein França MD, PhD.

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Conflict of interest

K. França, A. Kumar, M. Fioranelli, T. Lotti, M. Tirant, and M.G. Roccia declare that they have no competing interests.

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França, K., Kumar, A., Fioranelli, M. et al. The history of Botulinum toxin: from poison to beauty. Wien Med Wochenschr 167 (Suppl 1), 46–48 (2017). https://doi.org/10.1007/s10354-017-0553-7

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  • DOI: https://doi.org/10.1007/s10354-017-0553-7

Keywords

  • Botulinum toxin
  • History
  • Clostridium botulinum
  • Aesthetic
  • Remedy