Skip to main content
SpringerLink
Log in

Role of bile acid secretion in human colorectal cancer

Die Rolle der Gallensäuren bei der Entstehung des kolorektalen Karzinoms

  • Themenschwerpunkt
  • Published:
Wiener Medizinische Wochenschrift Aims and scope Submit manuscript

Zusammenfassung

Chol-, Deoxychol- und Lithocholsäure begünstigen die Tumorentstehung im Dickdarm durch direkte stimulierende Effekte auf die Proliferation von undifferenzierten Mukosaepithelzellen. Weiters können Gallensäuren bei der Entstehung des kolorektalen Karzinoms eine Rolle spielen, da sie die rezeptorvermittelte anti-mitogene Wirkung von Kalzium und Vitamin D auf neoplastische Kolonepithelzellen blockieren und dadurch deren chemopräventive Wirksamkeit reduzieren können.

Summary

Cholic, deoxycholic and lithocholic acid promote tumor formation in the large intestine by a direct proliferative effect on rather undifferentiated mucosal epithelial cells. In addition, bile acids may play a role in colorectal cancer pathogenesis because they reduce the chemopreventive efficiency of calcium and vitamin D by interfering with calcium and vitamin D receptor-activated anti-mitogenic intracellular signalling in neoplastic colonocytes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Lutz JM, Francisci S, Mugno E, Usel M, Pompe-Kirn V, Coebergh JW, Bieslka-Lasota M. Cancer prevalence in Central Europe: the EUROPREVAL Study. Ann Oncol, 14: 313–322, 2003

    Article  PubMed  CAS  Google Scholar 

  • Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin, 57: 43–66, 2007

    Article  PubMed  Google Scholar 

  • Reddy BS. Diet and excretion of bile acids. Cancer Res, 41(9 Pt 2): 3766–3768, 1981

    PubMed  CAS  Google Scholar 

  • Baijal PK, Clow EP, Fitzpatrick DW, Bird RP. Tumor-enhancing effects of cholic acid are exerted on the early stages of colon carcinogenesis via induction of aberrant crypt foci with an enhanced growth phenotype. Can J Physiol Pharmacol, 76: 1095–1102, 1998

    Article  PubMed  CAS  Google Scholar 

  • Baijal PK, Fitzpatrick DW, Bird RP. Comparative effects of secondary bile acids, deoxycholic and lithocholic acids, on aberrant crypt foci growth in the postinitiation phases of colon carcinogenesis. Nutr Cancer, 31: 81–89, 1998

    PubMed  CAS  Google Scholar 

  • Wargovich MJ, Eng VW, Newmark HL, Bruce WR. Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium. Carcinogenesis, 4: 1205–1207, 1983

    Article  PubMed  CAS  Google Scholar 

  • Newmark HL, Wargovich MJ. Colon cancer and dietary fat, phosphorus, and calcium in Hawaiian-Japanese men. Am J Clin Nutr, 44: 998–1000, 1986

    PubMed  CAS  Google Scholar 

  • Garland CF, Garland FC, Gorham ED. Can colon cancer incidence and death rates be reduced with calcium and vitamin D? Am J Clin Nutr, 54(1 Suppl): 193S–201S, 1991

    PubMed  CAS  Google Scholar 

  • Cross HS, Huber C, Peterlik M. Antiproliferative effect of 1,25-dihydroxyvitamin D3 and its analogs on human colon adenocarcinoma cells (CaCo-2): influence of extracellular calcium. Biochem Biophys Res Commun, 179: 57–62, 1991

    Article  PubMed  CAS  Google Scholar 

  • Cross HS, Pavelka M, Slavik J, Peterlik M. Growth control of human colon cancer cells by vitamin D and calcium in vitro. J Natl Cancer Inst, 84: 1355–1357, 1992

    Article  PubMed  CAS  Google Scholar 

  • Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, Sun A, Hediger MA, Lytton J, Hebert SC. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature, 366 (6455): 575–580, 1993

    Article  PubMed  CAS  Google Scholar 

  • Kállay E, Kifor O, Chattopadhyay N, Brown EM, Bischof MG, Peterlik M, Cross HS. Calcium-dependent c-myc proto-oncogene expression and proliferation of CaCo-2 cells: a role for a luminal extracellular calcium-sensing receptor. Biochem Biophys Res Commun, 232: 80–83, 1997

    Article  PubMed  Google Scholar 

  • Gama L, Baxendale-Cox LM, Breitwieser GE. Ca2+-sensing receptors in intestinal epithelium. Am J Physiol, 273(4 Pt 1): C1168–C1175, 1997

    PubMed  CAS  Google Scholar 

  • Kállay E, Bajna E, Wrba F, Kriwanek S, Peterlik M, Cross HS. Dietary calcium and growth modulation of human colon cancer cells: role of the extracellular calcium-sensing receptor. Cancer Detect Prev, 24: 127–136, 2000

    PubMed  Google Scholar 

  • Sheinin Y, Kallay E, Wrba F, Kriwanek S, Peterlik M, Cross HS. Immunocytochemical localization of the extracellular calcium-sensing receptor in normal and malignant human large intestinal mucosa. J Histochem Cytochem, 48: 595–602, 2000

    PubMed  CAS  Google Scholar 

  • Kudlacek S, Schneider B, Peterlik M, Leb G, Klaushofer K, Weber K, Woloszczuk W, Willvonseder R. Assessment of vitamin D and calcium status in healthy adult Austrians. Eur J Clin Invest, 33: 323–331, 2003

    Article  PubMed  CAS  Google Scholar 

  • Peterlik M, Cross HS. Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest, 35: 290–304, 2005

    Article  PubMed  CAS  Google Scholar 

  • Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, Mangelsdorf DJ. Vitamin D receptor as an intestinal bile acid sensor. Science, 296(5571): 1313–1316, 2002

    Article  PubMed  CAS  Google Scholar 

  • Nehring JA, Zierold C, DeLuca HF. Lithocholic acid can carry out in vivo functions of vitamin D. Proc Natl Acad Sci USA, 104: 10006–10009, 2007

    Article  PubMed  CAS  Google Scholar 

  • Nittke T, Selig S, Kallay E, Cross HS. Nutritional calcium modulates colonic expression of vitamin D receptor and pregnane X receptor target genes. Mol Nutr Food Res, 52(S1): 45–51, 2008

    Google Scholar 

  • Kawaura A, Tanida N, Sawada K, Oda M, Shimoyama T. Supplemental administration of 1 alpha-hydroxyvitamin D3 inhibits promotion by intrarectal instillation of lithocholic acid in N-methyl-N-nitrosourea-induced colonic tumorigenesis in rats. Carcinogenesis, 10: 647–649, 1989

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathophysiology, Medical University of Vienna, Vienna, Austria

    Meinrad Peterlik

Authors
  1. Meinrad Peterlik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Meinrad Peterlik.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Peterlik, M. Role of bile acid secretion in human colorectal cancer. Wien Med Wochenschr 158, 539–541 (2008). https://doi.org/10.1007/s10354-008-0601-4

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10354-008-0601-4

Schlüsselwörter

Keywords

Search

Navigation