Skip to main content

Advertisement

Log in

Relationship of preoperative serum calcium and extent of neck surgery to postoperative hospital stay in patients with primary hyperparathyroidism and severe bone disease. A case series

  • original article
  • Published:
European Surgery Aims and scope Submit manuscript

Summary

Introduction

After parathyroidectomy for patients with severe osteoporosis, hospital stay is likely to be prolonged because of rebound severe hypocalcemia. There is currently no method that predicts the occurrence of such an adverse effect. This study aimed to investigate preoperative serum calcium level and extent of neck surgery as predictors of the length of postoperative hospitalization.

Patients and methods

Fifty-five patients with primary hyperparathyroidism and severe bone disease had parathyroidectomies, 27 by a conventional bilateral exploration and 28 by focused unilateral surgery. The duration of postoperative hospitalization was tested for correlation to preoperative total serum calcium and to the extent of neck surgery.

Results

The median postoperative hospital stay was five days. After conventional exploration it was eight days, and after focused parathyroidectomy it was three days, a highly significant difference. Preoperative total calcium had an insignificant weak positive correlation with hospital stay.

Conclusion

For primary hyperparathyroidism with severe bone disease, focused unilateral parathyroidectomy is likely to reduce the duration of postoperative hospital stay. Preoperative total serum calcium is not a reliable predictor of hospital stay in this subset of patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Witteveen JE, van Thiel S, Romijn JA, Hamdy NAT. Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature. Eur J Endocrinol. 2013;168:R45–R53.

    Article  CAS  Google Scholar 

  2. Brasier AR, Nussbaum SR. Hungry bone syndrome: clinical and biochemical predictors of its occurrence in parathyroid surgery. Am J Med. 1988;84:654–60.

    Article  CAS  Google Scholar 

  3. Vasher M, Goodman A, Politz D, Norman J. Postoperative calcium requirements in 6,000 patients undergoing outpatient Parathyroidectomy: easily avoiding symptomatic hypocalcemia. J Am Coll Surg. 2010;211:49–54.

    Article  Google Scholar 

  4. Kidwai SM, Parasher AK, Ho YW, Teng MS, Genden EM. Risk stratification for outpatient parathyroidectomy and predictors of postoperative complications. Am J Otolaryngol. 2017;38:26–30.

    Article  Google Scholar 

  5. Strickland PL, Recabaren J. Are preoperative serum calcium, parathyroid hormone, and adenoma weight predictive of postoperative hypocalcaemia. Am Surg. 2002;68:1080–2.

    PubMed  Google Scholar 

  6. Mittendorf EA, Merlino JI, McHenry CR. Post-parathyroidectomy hypocalcemia: incidence, risk factors, and management. Am Surg. 2004;70:114–9.

    PubMed  Google Scholar 

  7. Zuberi KA, Urquhart AC. Serum PTH and ionized calcium levels as predictors of symptomatic hypocalcemia after parathyroidectomy. Laryngoscope. 2010;120(Suppl 4):S192.

    Article  Google Scholar 

  8. Kaya C, Tam AA, Dirikoç A, Kılıçyazgan A, Kılıç M, Türkölmez Ş, et al. Hypocalcemia development in patients operated for primary hyperparathyroidism: can it be predicted preoperatively? Arch Endocrinol Metab. 2016;60(5):465–71.

    Article  Google Scholar 

  9. Bergenfelz A, Lindblom P, Tibblin S, Westerdahl J. Unilateral versus bilateral neck exploration for primary hyperparathyroidism: a prospective randomized controlled trial. Ann Surg. 2002;236(5):543–51.

    Article  Google Scholar 

  10. Slepavicius A, Beisa V, Janusonis V, Strupas K. Focused versus conventional parathyroidectomy for primary hyperparathyroidism: a prospective, randomized, blinded trial. Langenbecks Arch Surg. 2008;393(5):659–66.

    Article  Google Scholar 

  11. Schneider DF, Mazeh H, Sippel RS, Chen H. Is minimally invasive parathyroidectomy associated with greater recurrence compared to bilateral exploration? Analysis of more than 1,000 cases. Surgery. 2012;152(6):1008–15.

    Article  Google Scholar 

  12. Kim SM, Shu AD, Long J, Montez-Rath ME, Leonard MB, Norton JA, et al. Declining rates of inpatient parathyroidectomy for primary hyperparathyroidism in the US. PLoS ONE. 2016;11(8):e161192.

    Article  Google Scholar 

  13. Silverberg SJ, Clarke BL, Peacock M, et al. Current issues in the presentation of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop. J Clin Endocrinol Metab. 2014;99:3580–94.

    Article  CAS  Google Scholar 

  14. Agha RA, Borrelli MR, Farwana R, Koshy K, Fowler A, Orgill DP, et al. The PROCESS 2018 statement: updating consensus preferred reporting of CasE series in surgery (PROCESS) guidelines. Int J Surg. 2018;60:279–82.

    Article  Google Scholar 

  15. Kanis JA, Melton LJ 3rd, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9:1137–41.

    Article  CAS  Google Scholar 

  16. Ishii H, Mihai R, Watkinson JC, Kim DS. Systematic review of cure and recurrence rates following minimally invasive parathyroidectomy. BJS Open. 2018;2:364–70.

    Article  CAS  Google Scholar 

  17. Walsh NJ, Sullivan BT, Duke WS, Terris DJ. Routine bilateral neck exploration and four-gland dissection remains unnecessary in modern parathyroid surgery. Laryngoscope Investig Otolaryngol. 2018;4(1):188–92.

    Article  Google Scholar 

  18. Norman J, Lopez J, Politz D. Abandoning unilateral parathyroidectomy: why we reversed our position after 15,000 parathyroid operations. J Am Coll Surg. 2012;214:260–9.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Amr Abdallah Mohsen M.D., FRCSEd.

Ethics declarations

Conflict of interest

H.M. Mikhail, A.A. Mohsen, and A.A. Mohsen declare that they have no competing interests.

Ethical standards

For this article, no studies with human participants or animals were performed by any of the authors. Informed consent was obtained from all patients for being included in the study. Consent included permission to use their tested factors (preoperative serum calcium and extent of surgery) and the outcome parameter (hospital stay) for this research study.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mikhail, H.M., Mohsen, A.A. & Mohsen, A.A. Relationship of preoperative serum calcium and extent of neck surgery to postoperative hospital stay in patients with primary hyperparathyroidism and severe bone disease. A case series. Eur Surg 52, 96–99 (2020). https://doi.org/10.1007/s10353-019-00608-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10353-019-00608-0

Keywords

Navigation