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Current treatment concepts of Pancoast tumors

Aktuelle Behandlungskonzepte von Pancoast-Tumoren

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Zusammenfassung

GRUNDLAGEN: Nicht-kleinzellige Bronchuskarzinome, welche die obere Thoraxapertur infiltrieren – auch Pancoast-Tumore genannt – sind aufgrund ihrer Nahebeziehung zu den vitalen Strukturen des Apex ein therapeutisch besonders herausfordernder Teil der Lungenkarzinome. METHODIK: Diese Reviewarbeit fokussiert auf klinische Ergebnisse unterschiedlicher Therapieansätze und auf verschiedene chirurgische Zugänge zu Pancoast-Tumoren. ERGEBNISSE: Die Therapiekonzepte haben sich im Laufe der Zeit substantiell weiterentwickelt, was in signifikant erhöhte Langzeitüberlebensraten resultiert. SCHLUSSFOLGERUNGEN: Ein multimodaler Zugang mit einer neoadjuvanten Chemoradiatio gefolgt von chirurgischer Resektion hat sich als Standardtherapie bei lokalisiertem Krankheitsgeschehen etabliert.

Summary

BACKGROUND: Non-small-cell lung cancers involving the superior sulcus, also termed Pancoast tumors, are a challenging subset of lung carcinomas due to their proximity to vital structures at the thoracic inlet. METHODS: This review focuses on clinical outcome data of different treatment regimens and surgical approaches to Pancoast tumors. RESULTS: Therapeutical standards have constantly evolved over time leading to significantly improved long-term survival rates. CONCLUSIONS: A multimodal regimen approach consisting of induction chemoradiation followed by surgical resection has become the standard treatment concept in localized disease.

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  1. Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria

    C. Aigner & W. Klepetko

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  1. C. Aigner
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  2. W. Klepetko
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Correspondence to C. Aigner.

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Aigner, C., Klepetko, W. Current treatment concepts of Pancoast tumors. Eur Surg 42, 214–219 (2010). https://doi.org/10.1007/s10353-010-0556-8

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  • DOI: https://doi.org/10.1007/s10353-010-0556-8

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