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Tissue Engineering Generation of adipose tissue: an overview of current standards and possibilities

Herstellung von Fettgewebe mittels Tissue Engineering: Überblick zum aktuellen Stand und neue Möglichkeiten

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Zusammenfassung

GRUNDLAGEN: Die Forschung auf dem Gebiet des Tissue Engineerings hat sich im Laufe der letzten Jahre rasch entwickelt und bietet alternative Strategien für die Fettgewebsaugmentation an, die den traditionellen chirurgischen Verfahren überlegen sein könnte. METHODIK: Dieser Übersichtsartikel soll einen Überblick zum Thema Tissue Engineering liefern und die aktuellen Forschungsergebnisse zu diesem Thema durchleuchten. ERGEBNISSE: Der Grundsatz dieser neuen Verfahren basiert entweder darauf lebende Zellen eines Organismus außerhalb des Zielgewebes zu kultivieren und anschließend zu implantieren (in vitro Tissue engineering) oder eine Matrix in den Organismus einzubringen, um eine Geweberegeneration zu veranlassen (in vivo Tissue Engineering) und die richtige Funktion des Gewebes wieder herzustellen. Es gibt zahlreiche verschiedene Verfahren, die verfügbar sind, um Fettgewebe zu generieren. SCHLUSSFOLGERUNGEN: Langfristig werden wahrscheinlich konventionelle reparative Verfahren durch regenerative Verfahren abgelöst.

Summary

BACKGROUND: Research in tissue engineering has developed rapidly over the last years and offers alternative strategies for soft tissue augmentation, which might be superior to traditional surgical options. METHODS: This review article gives an outline of the basics of tissue engineering and reviews the latest research in this field. RESULTS: The principle of this new approach is either to cultivate living cells of an organism outside of the target tissue to finally implant them to the same organism (in vitro tissue engineering) or to insert a matrix into an organism to induce the generation of tissue and to restore the proper function of the tissue (in vivo tissue engineering). There are numerous different approaches available to generate adipose tissue. CONCLUSIONS: The conventional reparative approach will be replaced by a regenerative approach.

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  1. Vienna Burn Center, Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria

    M. Keck, L.-P. Kamolz & M. Frey

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  1. M. Keck
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  2. L.-P. Kamolz
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Correspondence to L.-P. Kamolz.

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Keck, M., Kamolz, LP. & Frey, M. Tissue Engineering Generation of adipose tissue: an overview of current standards and possibilities. Eur Surg 42, 164–170 (2010). https://doi.org/10.1007/s10353-010-0548-8

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