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The Effects of Intraperitoneal Sildenafil Administration on Healing of Left Colonic Anastomoses and Intra-Abdominal Adhesion Formation in the Presence of Intra-Abdominal Infection

  • Original Contribution
  • Published:
Diseases of the Colon & Rectum

Abstract

Purpose

The objective of this pilot study was to establish an animal model for intra-abdominal infection and to examine the effect of sildenafil on anastomotic healing of the left colon and intra-abdominal adhesion formation.

Methods

Fourteen Winstar rats underwent colonic transsection and primary anastomosis after performing intra-abdominal infection. Rats were divided into two groups: Group 1 (n = 7): intra-abdominal infection, resection, and anastomoses; Group 2 (n = 7): intra-abdominal infection, resection, anastomoses, and sildenafil. Anastomotic bursting pressures, hydroxyproline levels, histopathologic grading, and abdominal adhesions were accessed on the postoperative Day 7.

Results

Anastomotic healing was found to be improved in terms of a bursting pressure (P = 0.02). Histopathological examination revealed an increase in angiogenesis (P = 0.007). Moreover, intra-abdominal adhesions were significantly less in rats given sildenafil (P = 0.03).

Conclusion

Sildenafil may improve anastomotic healing of the left colon and diminishes peritoneal adhesion formation in the presense of abdominal infection.

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Author information

Authors and Affiliations

  1. Department of General Surgery, Faculty of Medicine, Firat University, Elazig, Turkey

    Refik Ayten M.D., Ziya Çetinkaya M.D. & Erhan Aygen M.D.

  2. Department of General Surgery, Bingol City Hospital, Bingol, Turkey

    Mustafa Girgin M.D.

  3. Department of Pathology, Faculty of Medicine, Firat University, Elazig, Turkey

    İbrahim Ozercan M.D.

  4. Department of Biochemistry, Faculty of Medicine, Firat University, Elazig, Turkey

    Bilal Ustundag M.D.

Authors
  1. Refik Ayten M.D.
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  2. Ziya Çetinkaya M.D.
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  3. Mustafa Girgin M.D.
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  4. İbrahim Ozercan M.D.
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  5. Bilal Ustundag M.D.
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  6. Erhan Aygen M.D.
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Correspondence to Refik Ayten M.D..

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Ayten, R., Çetinkaya, Z., Girgin, M. et al. The Effects of Intraperitoneal Sildenafil Administration on Healing of Left Colonic Anastomoses and Intra-Abdominal Adhesion Formation in the Presence of Intra-Abdominal Infection. Dis Colon Rectum 51, 1837–1841 (2008). https://doi.org/10.1007/s10350-008-9398-x

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  • DOI: https://doi.org/10.1007/s10350-008-9398-x

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