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Optical Coherence Tomography in Inflammatory Bowel Disease: Prospective Evaluation of 35 Patients

  • Original Contribution
  • Published:
Diseases of the Colon & Rectum

Abstract

Purpose

Optical coherence tomography is a technique using infrared light in tissues of the gastrointestinal tract and human colon affected by inflammatory diseases. We evaluated whether there are specific patterns of optical coherence tomography for inflammatory bowel disease and compared the technique performance to the histology.

Methods

Optical coherence tomography was performed in 35 patients (18 men; 31 ulcerative colitis, 4 Crohn’s disease). The images were obtained from affected and normal colon at endoscopy. Two biopsies of the sites visualized were taken. Two endoscopists scored the images, and two pathologists, blind to the endoscopy and optical coherence tomography, performed the histologic evaluation.

Results

Three optical coherence tomography patterns were identified: 1) mucosal backscattering alteration, 2) delimited dark areas, and 3) layered colonic wall. Compared with the histology, mucosal backscattering alteration was the most effective in recognizing the disease in patients (P = 0.007 in colon segments affected, and P < 0.001 in normal segments). The sensitivity and specificity have been 100 and 78 percent, respectively.

Conclusions

The in vivo optical coherence tomography correctly detected inflammatory bowel disease features in affected and apparently normal colon, and allowed to discriminate patterns for active ulcerative colitis and Crohn’s disease.

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Authors and Affiliations

  1. Department of Medicine and Pharmacology, University Hospital, Messina, Italy

    P. Consolo M.D., G. Strangio M.D., C. Luigiano M.D., G. Giacobbe M.D., S. Pallio M.D. & L. Familiari M.D., Ph.D.

  2. Department of Medicine and Pharmacology-Endoscopy Unit, University Hospital, Via Consolare Valeria, 1, 98125, Messina, Italy

    L. Familiari M.D., Ph.D.

Authors
  1. P. Consolo M.D.
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  2. G. Strangio M.D.
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  3. C. Luigiano M.D.
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  4. G. Giacobbe M.D.
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  5. S. Pallio M.D.
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  6. L. Familiari M.D., Ph.D.
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Corresponding author

Correspondence to L. Familiari M.D., Ph.D..

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Consolo, P., Strangio, G., Luigiano, C. et al. Optical Coherence Tomography in Inflammatory Bowel Disease: Prospective Evaluation of 35 Patients. Dis Colon Rectum 51, 1374–1380 (2008). https://doi.org/10.1007/s10350-008-9304-6

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  • DOI: https://doi.org/10.1007/s10350-008-9304-6

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