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Insulin Therapy and Colorectal Adenoma Risk Among Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Korea

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Diseases of the Colon & Rectum

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Abstract

Purpose

Patients with Type 2 diabetes mellitus may be at increased colorectal adenoma and cancer risk. Moreover, chronic insulin therapy may increase the risk of colorectal cancer among patients with Type 2 diabetes mellitus. We investigated to determine whether insulin therapy might increase the risk of colorectal adenoma among clinically confirmed patients with Type 2 diabetes mellitus.

Methods

We conducted a retrospective study among patients with Type 2 diabetes mellitus who underwent total colonoscopy between January 2003 and July 2006 at Hallym University Sacred Heart Hospital. Among them (n = 325), patients with histologically confirmed colorectal adenomas (n = 100) and the same number of controls matched by age and sex were selected and analyzed.

Results

Adenoma cases showed significantly higher rate of chronic insulin therapy (more than 1 year) than controls (P = 0.018). In multivariate regression analysis, patients who received chronic insulin therapy had three times the risk of colorectal adenoma compared with patients who received no insulin (odds ratio, 3; 95 percent confidence interval, 1.1–8.9; P = 0.04).

Conclusions

Chronic insulin therapy was associated with increased colorectal adenoma risk among Type 2 diabetes mellitus patients. This result may provide a need for more intensive colorectal cancer screening program in patients with Type 2 diabetes mellitus, especially those who receive chronic insulin therapy.

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Authors and Affiliations

  1. Department of Gastroenterology, Hallym University Sacred Heart Hospital, Anyang, South Korea

    Yong Woo Chung M.D., Kwang Hyuk Park M.D., Kyo-Sang Yoo M.D. & Choong Kee Park M.D.

  2. Department of Gastroenterology, Hanyang University Guri Hospital, Guri, South Korea

    Dong Soo Han M.D. & Chang Soo Eun M.D.

Authors
  1. Yong Woo Chung M.D.
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  2. Dong Soo Han M.D.
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  3. Kwang Hyuk Park M.D.
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  4. Chang Soo Eun M.D.
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  5. Kyo-Sang Yoo M.D.
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  6. Choong Kee Park M.D.
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Corresponding author

Correspondence to Dong Soo Han M.D..

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Chung, Y.W., Han, D.S., Park, K.H. et al. Insulin Therapy and Colorectal Adenoma Risk Among Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Korea. Dis Colon Rectum 51, 593–597 (2008). https://doi.org/10.1007/s10350-007-9184-1

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  • DOI: https://doi.org/10.1007/s10350-007-9184-1

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