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Ulcerative Colitis Accompanied with Sarcoidosis and Dermatomyositis: Report of a Case

  • Case Report
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Diseases of the Colon & Rectum

Abstract

We report a rare case of ulcerative colitis with sarcoidosis and dermatomyositis. A 33-year old woman had a ten-year history of ulcerative colitis and dermatomyositis. After nine-year maintenance treatment with sulphasalazine and steroids, she underwent a proctocolectomy and ileal pouch-anal anastomosis because of deterioration of ulcerative colitis. One year after the operation, she noticed some subcutaneous masses in the right forearm and left lower leg. A total biopsy of the mass was performed, and noncaseous epithelioid granulomas were found in the specimen. Chest roentgenogram and chest computed tomography showed hilar adenopathy and a diffuse granular shadow. The diagnosis of sarcoidosis was made. Concomitant development of ulcerative colitis and sarcoidosis may not be incidental, and there may be a common factor in the two diseases. Ulcerative colitis also may be a part of a systemic disorder associated with abnormal immune reactions. Complications by disorders associated with other immunologic abnormalities, as noted in this patient, should be kept in mind in the management of ulcerative colitis.

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References

  1. Trujillo NP, Halstead LS, Ticktin HE. Chronic ulcerative colitis, xanthomatous biliary cirrhosis and sarcoidosis. Report of a case. Med Ann Dist Columbia 1967;36:170–4.

    PubMed  CAS  Google Scholar 

  2. Jalan KN, MacLean N, Ross JM, Sircus W, Butterworth ST. Carcinoma of the terminal ileum and sarcoidosis in a case of ulcerative colitis. Gastroenterology 1969;56:583–8.

    PubMed  CAS  Google Scholar 

  3. Watson DW, Friedman HM, Quigley A. Immunological studies in a patient with ulcerative colitis and sarcoidosis. Gut 1971;12:541–3.

    Google Scholar 

  4. Theodoropoulos G, Archimandritis A, Davaris P, Plataris J, Melissinos K. Ulcerative colitis and sarcoidosis: a curious association. Report of a case. Dis Colon Rectum 1981;24:308–10.

    PubMed  CAS  Google Scholar 

  5. Barr GD, Shale DJ, Jewell DP. Ulcerative colitis and sarcoidosis. Postgrad Med J 1986;62:341–5.

    Article  PubMed  CAS  Google Scholar 

  6. Van Steenbergen W, Fevery J, Vandenbrande P, et al. Ulcerative colitis, primary sclerosing cholangitis, bile duct carcinoma, and generalized sarcoidosis. Report of a unique association. J Clin Gastroenterol 1987;9:574–9.

    Article  PubMed  Google Scholar 

  7. Fries W, Grassi SA, Leone L, et al. Association between inflammatory bowel disease and sarcoidosis. Report of two cases and review of the literature. Scand J Gastroenterol 1995;30:1221–3.

    Article  PubMed  CAS  Google Scholar 

  8. Le Gall F, Loeuillet L, Delaval P, Thoreux PH, Desrues B, Ramee MP. Necrotizing sarcoid granulomatosis with and without extrapulmonary involvement. Pathol Res Pract 1996;192:306–14.

    PubMed  Google Scholar 

  9. Yoshioka K, Nishimura S, Kitai S, Kondo M. Association of sarcoidosis, insulin-dependent diabetes mellitus, and ulcerative colitis. Arch Intern Med 1997;157:465–7.

    Article  PubMed  CAS  Google Scholar 

  10. Nilubol N, Taub PJ, Venturero M, Lichtiger S, Bauer JJ. Ulcerative colitis and sarcoidosis. Mt Sinai J Med 2001;68:400–2.

    PubMed  CAS  Google Scholar 

  11. Vaiphei K, Gupta N, Sinha SK, Nagi B, Singh K. Association of ulcerative colitis with pulmonary sarcoidosis, subcutaneous lipomatosis and appendiceal adenocarcinoma. Indian J Gastroenterol 2003;22:193–4.

    PubMed  CAS  Google Scholar 

  12. Kobayashi S, Higuchi K, Tamaki H, Wada Y, Wada N, Kubo M, Koike Y, Nagata M, Tatsuzawa O, Fujikawa S. Characteristics of juvenile dermatomyositis in Japan. Acta Paediatr Jpn 1997;39:257–62.

    Google Scholar 

  13. Cottone M, Bunce M, Taylor CJ, Ting A, Jewell DP. Ulcerative colitis and HLA phenotype. Gut 1985;26:952–4.

    Article  PubMed  CAS  Google Scholar 

  14. Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med 1999;160:736–55.

    Google Scholar 

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Correspondence to Tadataka Hayashi M.D..

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Presented at the Digestive Disease Week (DDW)-Japan 2005 meeting, Kobe, Hyogo, Japan, October 5 to 8, 2005.

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Hayashi, T., Nakamura, T., Kurachi, K. et al. Ulcerative Colitis Accompanied with Sarcoidosis and Dermatomyositis: Report of a Case. Dis Colon Rectum 51, 474–476 (2008). https://doi.org/10.1007/s10350-007-9165-4

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  • DOI: https://doi.org/10.1007/s10350-007-9165-4

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