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Prevalence of Anal Cytologic Abnormalities in a French Referral Population: A Prospective Study with Special Emphasis on HIV, HPV, and Smoking

  • Original Contribution
  • Published:
Diseases of the Colon & Rectum

Abstract

Purpose

Studying anal cytology to detect intraepithelial neoplasia has been demonstrated to be useful in highly selected populations. This study was designed to determine the frequency of abnormal smears in a wide sample of patients consulting for anorectal symptoms.

Methods

An anal smear was proposed during each consultation during a three-month period.

Results

A total of 205 patients (112 females) were included. After the consultation, visible condylomas were detected in 12 (6 percent) of the cases. Two hundred three (99 percent) smears were able to be analyzed. No case of high-grade squamous intraepithelial lesion was found. Four cases of low-grade squamous intraepithelial lesion were found, all in HIV patients with a history of condylomatous lesions. Forty smears were interpreted as atypical squamous cells of undetermined significance and 159 were normal. The prevalence in this population of low-grade squamous intraepithelial lesion was 19 percent (4/21) in HIV seropositive males, and 15 percent (4/26) in the case of a past history of condyloma. The factors associated with an abnormal smear (low-grade squamous intraepithelial lesion or atypical squamous cells of undetermined significance) were a history of anal condylomatous lesions (odd ratio, 4.9; range, 2.1–11.5), HIV seropositivity (odd ratio, 4; range, 1.6–9.9), and smoking (odd ratio, 2.1; range, 1.1–11.5).

Conclusions

This work confirms that the frequency of low-grade squamous intraepithelial lesion is raised in HIV-seropositive males and also where there is a history of condyloma, which corroborates the necessity for regular monitoring and screening of these patients at risk. This study also suggests that the use of tobacco is associated with anal cytologic abnormalities.

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Author information

Authors and Affiliations

  1. Proctologie Médico-Interventionnelle, Groupe Hospitalier Diaconesses-Croix Saint-Simon, 18 rue du sergent Bauchat, 75012, Paris, France

    Isabelle Etienney M.D., Fady Daniel M.D., Benoît Mory M.D., Milad Taouk M.D., Samy Sultan M.D., Christian Thomas M.D., Josée Bourguignon M.D., Vincent de Parades M.D., Nathalie Méary M.D., Patrick Atienza M.D. & Pierre Bauer M.D.

  2. Centre d’Anatomo-Pathologie, Bièvres, France

    Sarra Vuong M.D. & André Balaton M.D.

Authors
  1. Isabelle Etienney M.D.
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  2. Sarra Vuong M.D.
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  3. Fady Daniel M.D.
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  4. Benoît Mory M.D.
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  5. Milad Taouk M.D.
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  6. Samy Sultan M.D.
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  7. Christian Thomas M.D.
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  8. Josée Bourguignon M.D.
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  9. Vincent de Parades M.D.
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  10. Nathalie Méary M.D.
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  11. André Balaton M.D.
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  12. Patrick Atienza M.D.
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  13. Pierre Bauer M.D.
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Corresponding author

Correspondence to Isabelle Etienney M.D..

Additional information

Supported by a grant from Beaufour Ipsen Pharma. Paris, France

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Cite this article

Etienney, I., Vuong, S., Daniel, F. et al. Prevalence of Anal Cytologic Abnormalities in a French Referral Population: A Prospective Study with Special Emphasis on HIV, HPV, and Smoking. Dis Colon Rectum 51, 67–72 (2008). https://doi.org/10.1007/s10350-007-9098-y

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  • DOI: https://doi.org/10.1007/s10350-007-9098-y

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