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Differences in Yeast Intolerance Between Patients with Crohn’s Disease and Ulcerative Colitis

  • Published:
Diseases of the Colon & Rectum

Purpose

Alimentary factors, especially those modifying the intestinal flora, may influence the course of inflammatory bowel disease. It is known that T and B cells of patients with Crohn’s disease can be stimulated with the yeast antigen, mannan. We evaluated the impact of eating habits with special respect to food containing yeast on the course of inflammatory bowel disease.

Methods

Questionnaires were sent to 180 German-speaking patients of the Inflammatory Bowel Disease Outpatient Clinic at the University Hospital Bern, Switzerland. The following information was obtained by the questionnaires: (1) course of disease, (2) eating habits, (3) environmental data, and (4) inflammatory bowel disease questionnaire. The survey was anonymous.

Results

A total of 145 patients (80.5 percent 95 with Crohn’s disease, and 50 with ulcerative colitis) responded. Food items containing yeast were better tolerated by patients with ulcerative colitis than by patients with Crohn’s disease. A significant difference between the two groups was observed concerning food containing raw yeast (dough, P = 0.04; and pastry, P = 0.001).

Conclusions

Food items containing raw yeast led to more frequent problems for patients with Crohn’s disease than for patients with ulcerative colitis. This observation supports our previous data, which showed the stimulatory effect of the yeast antigen, mannan, on B and T cells of patients with Crohn’s disease but not of controls.

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References

  1. BM Calkins (1989) ArticleTitleA meta-analysis of the role of smoking in inflammatory bowel disease Dig Dis Sci 34 1841–1854 Occurrence Handle2598752 Occurrence Handle10.1007/BF01536701 Occurrence Handle1:STN:280:DyaK3c%2FptFOjtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  2. LR Sutherland S Ramcharan H Bryant G Fick (1990) ArticleTitleEffect of cigarette smoking on recurrence of Crohn’s disease Gastroenterology 98 1123–1128 Occurrence Handle2323505 Occurrence Handle1:STN:280:DyaK3c3hsFSrug%3D%3D

    PubMed  CAS  Google Scholar 

  3. CL Sutton H Yang Z Li JI Rotter SR Targan J Braun (2000) ArticleTitleFamilial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn’s disease Gut 46 58–63 Occurrence Handle10601056 Occurrence Handle10.1136/gut.46.1.58 Occurrence Handle1:STN:280:DC%2BD3c%2FmvFGjsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  4. S Vermeire S Joossens M Peeters et al. (2001) ArticleTitleComparative study of ASCA (anti-Saccharomyces cerevisiae antibody) assays in inflammatory bowel disease Gastroenterology 120 827–833 Occurrence Handle11231936 Occurrence Handle10.1053/gast.2001.22546 Occurrence Handle1:CAS:528:DC%2BD3MXitlert70%3D

    Article  PubMed  CAS  Google Scholar 

  5. F Seibold O Stich R Hufnagl S Kamil M Scheurlen (2001) ArticleTitleAnti-Saccharomyces cerevisiae antibodies in inflammatory bowel disease: a family study Scand J Gastroenterol 36 196–201 Occurrence Handle11252413 Occurrence Handle1:STN:280:DC%2BD3MzmvVWlug%3D%3D Occurrence Handle10.1080/003655201750065960

    Article  PubMed  CAS  Google Scholar 

  6. S Vermeire M Peeters R Vlictinck et al. (2001) ArticleTitleAnti-Saccharomyces cerevisiae antibodies (ASCA), phenotypes of IBD, and intestinal permeability: a study in IBD families Inflamm Bowel Dis 7 8–15 Occurrence Handle11233666 Occurrence Handle10.1097/00054725-200102000-00002 Occurrence Handle1:STN:280:DC%2BD3M3ksFKktQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  7. M Peeters S Joossens S Vermeire R Vlietinck X Bossuyt P Rutgeerts (2001) ArticleTitleDiagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease Am J Gastroenterol 96 730–734 Occurrence Handle11280542 Occurrence Handle10.1111/j.1572-0241.2001.03613.x Occurrence Handle1:STN:280:DC%2BD3M7ovFOktg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  8. V Annese A Andreoli A Andriulli et al. (2001) ArticleTitleFamilial expression of anti-Saccharomyces cerevisiae mannan antibodies in Crohn’s disease and ulcerative colitis: aGISC study Am J Gastroenterol 96 2407–2412 Occurrence Handle11513182 Occurrence Handle10.1111/j.1572-0241.2001.04043.x Occurrence Handle1:STN:280:DC%2BD3MvmvVKruw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  9. JF Quinton B Sendid D Reumaux et al. (1998) ArticleTitleAnti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role Gut 42 788–791 Occurrence Handle9691915 Occurrence Handle1:CAS:528:DyaK1cXlslChs7o%3D Occurrence Handle10.1136/gut.42.6.788

    Article  PubMed  CAS  Google Scholar 

  10. A Konrad C Rutten B Flogerzi M Styner B Goke F Seibold (2004) ArticleTitleImmune sensitization to yeast antigens in ASCA-positive patients with Crohn’s disease Inflamm Bowel Dis 10 97–105 Occurrence Handle15168808 Occurrence Handle10.1097/00054725-200403000-00006

    Article  PubMed  Google Scholar 

  11. F Seibold A Konrad B Flogerzi et al. (2004) ArticleTitleGenetic variants of the mannan-binding lectin are associated with immune reactivity to mannans in Crohn’s disease Gastroenterology 127 1076–1084 Occurrence Handle15480986 Occurrence Handle10.1053/j.gastro.2004.07.056 Occurrence Handle1:CAS:528:DC%2BD2cXpsVOitrk%3D

    Article  PubMed  CAS  Google Scholar 

  12. R Medzhitov (2001) ArticleTitleToll-like receptors and innate immunity Nat Rev Immunol 1 135–145 Occurrence Handle11905821 Occurrence Handle10.1038/35100529 Occurrence Handle1:CAS:528:DC%2BD38XlvF2qu74%3D

    Article  PubMed  CAS  Google Scholar 

  13. H Tada E Nemoto H Shimauchi et al. (2002) ArticleTitleSaccharomyces cerevisiae and Candida albicans derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD 14- and Toll-like receptor 4- dependent manner Microbiol Immunol 46 503–512 Occurrence Handle12222939 Occurrence Handle1:CAS:528:DC%2BD38Xmtl2mt7g%3D

    PubMed  CAS  Google Scholar 

  14. D Franchimont S Vermeire H Housni et al. (2004) ArticleTitleDeficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis Gut 53 987–992 Occurrence Handle15194649 Occurrence Handle10.1136/gut.2003.030205 Occurrence Handle1:CAS:528:DC%2BD2cXlvFemtrY%3D

    Article  PubMed  CAS  Google Scholar 

  15. A Mitchell G Guyatt J Singer et al. (1988) ArticleTitleQuality of life in patients with inflammatory bowel disease J Clin Gastroenterol 10 306–310 Occurrence Handle2980766 Occurrence Handle10.1097/00004836-198806000-00014 Occurrence Handle1:STN:280:DyaK38zjt12qsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  16. G Guyatt A Mitchell EJ Irvine et al. (1989) ArticleTitleA new measure of health status for clinical trials in inflammatory bowel disease Gastroenterology 96 804–810 Occurrence Handle2644154 Occurrence Handle1:STN:280:DyaL1M7itFequg%3D%3D

    PubMed  CAS  Google Scholar 

  17. J Kocourek CE Ballou (1969) ArticleTitleMethod for fingerprinting yeast cell wall mannans J Bacteriol 100 1175–1181 Occurrence Handle5361210 Occurrence Handle1:CAS:528:DyaE3cXivVeqsw%3D%3D

    PubMed  CAS  Google Scholar 

  18. JF Mayberry J Rhodes (1984) ArticleTitleEpidemiological aspects of Crohn’s disease: a review of literature Gut 25 886–899 Occurrence Handle6086465 Occurrence Handle1:STN:280:DyaL2c3mt1GqtA%3D%3D

    PubMed  CAS  Google Scholar 

  19. BM Calkins AI Medeloff (1986) ArticleTitleEpidemiology of inflammatory bowel disease Epidemiol Rev 8 60–91 Occurrence Handle3533585 Occurrence Handle1:STN:280:DyaL2s%2FjtVKgtQ%3D%3D

    PubMed  CAS  Google Scholar 

  20. GR Barclay H McKenzie J Pennington D Parratt CR Pennington (1992) ArticleTitleThe effect of dietary yeast on the activity of stable chronic Crohn’s disease Scand J Gastroenterol 27 196–200 Occurrence Handle1502481 Occurrence Handle1:STN:280:DyaK38zms12jtA%3D%3D

    PubMed  CAS  Google Scholar 

  21. EA Vasiliauskas LY Kam LC Karp J Gaiennie H Yang SR Targan (2000) ArticleTitleMarker antibody expression stratifies Crohn’s disease into immunologically homogenous subgroups with distinct clinical characteristics Gut 47 487–496 Occurrence Handle10986208 Occurrence Handle10.1136/gut.47.4.487 Occurrence Handle1:CAS:528:DC%2BD3cXnsVCrurs%3D

    Article  PubMed  CAS  Google Scholar 

  22. LJ Walker MC Aldhous HE Drummond et al. (2004) ArticleTitleAnti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn’s disease are associated with disease severity but not NOD2/CARD15 mutations Clin Exp Immunol 135 490–496 Occurrence Handle15008984 Occurrence Handle10.1111/j.1365-2249.2003.02392.x Occurrence Handle1:CAS:528:DC%2BD2cXislalsbY%3D

    Article  PubMed  CAS  Google Scholar 

  23. A Zholudev D Zurakowski W Young A Leichtner A Bousvaros (2004) ArticleTitleSerologic testing with ANCA, ASCA, and anti-OmpC in children and young adults with Crohn’s disease and ulcerative colitis: diagnostic value and correlation with disease phenotype Am J Gastroenterol 99 2235–2241 Occurrence Handle15555007 Occurrence Handle10.1111/j.1572-0241.2004.40369.x

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterology, University of Bern, Inselspital, Bern, Switzerland

    Brigitt Brunner M.D., Ulrich Scheurer M.D. & Frank Seibold M.D.

  2. Kantonsspital Uri, 6460, Altdorf, Switzerland

    Brigitt Brunner M.D.

Authors
  1. Brigitt Brunner M.D.
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  2. Ulrich Scheurer M.D.
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  3. Frank Seibold M.D.
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Correspondence to Brigitt Brunner M.D..

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Brunner, B., Scheurer, U. & Seibold, F. Differences in Yeast Intolerance Between Patients with Crohn’s Disease and Ulcerative Colitis. Dis Colon Rectum 50, 83–88 (2007). https://doi.org/10.1007/s10350-006-0749-1

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  • DOI: https://doi.org/10.1007/s10350-006-0749-1

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