References
MM Borner P Schoffski R Wit Particlede et al. (2002) ArticleTitlePatient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancer Eur J Cancer 38 349–358 Occurrence Handle11818199 Occurrence Handle1:CAS:528:DC%2BD38XovFShsQ%3D%3D Occurrence Handle10.1016/S0959-8049(01)00371-9
RG Hahn CG Moertel AJ Schutt HW Bruckner (1975) ArticleTitleA double-blind comparison of intensive course 5-flourouracil by oral vs. intravenous route in the treatment of colorectal carcinoma Cancer 35 1031–1035 Occurrence Handle1090358 Occurrence Handle1:STN:280:CSqC3M%2Fls1I%3D Occurrence Handle10.1002/1097-0142(197504)35:4<1031::AID-CNCR2820350403>3.0.CO;2-N
MA Friedman RJ Ignoffo (1980) ArticleTitleA review of the United States clinical experience of the fluoropyridimine, Ftorafur (NSC-148958) Cancer Treat Rev 7 205–213 Occurrence Handle6783303 Occurrence Handle1:STN:280:Bi6C283ksFI%3D Occurrence Handle10.1016/S0305-7372(80)80037-5
J Sakamoto C Hamada S Kodaira H Nakazato Y Ohashi (1999) ArticleTitleAdjuvant therapy with oral fluoropyrimidines as main chemotherapeutic agents after curative resection for colorectal cancer: individual patient data meta-analysis of randomized trials Jpn J Clin Oncol 29 78–86 Occurrence Handle10089948 Occurrence Handle1:STN:280:DyaK1M7ovFyiug%3D%3D Occurrence Handle10.1093/jjco/29.2.78
A Hoshi M Iigo M Yoshida K Kuretani (1975) ArticleTitleAntitumor activity of carbamoyl derivatives of 5-fluorouracil by oral administration Gann 66 673–674 Occurrence Handle1225720 Occurrence Handle1:CAS:528:DyaE28XhtFGkur8%3D
A Hoshi M Iigo A Nakamura M Yoshida K Kuretani (1976) ArticleTitleAntitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors Gann 67 725–731 Occurrence Handle1017587 Occurrence Handle1:CAS:528:DyaE2sXltVGqsg%3D%3D
InstitutionalAuthorNameHCFU Clinical Study Group (1980) ArticleTitleAbsorption and excretion of new oral antitumor drug, 1-hexylcarbamoyl-5-fluorouracil (HCFU), in cancer patients Jpn J Clin Oncol 10 83–92
M Iigo A Hoshi A Nakamura K Kuretani (1978) ArticleTitleAntitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil in a variety of mouse tumors Cancer Chemother Pharmacol 1 203–208 Occurrence Handle750108 Occurrence Handle1:CAS:528:DyaE1MXktlalt78%3D Occurrence Handle10.1007/BF00257150
Y Koyama (1981) ArticleTitle1-hexylcarbamoyl-5-fluorouracil (HCFU): a masked 5-fluorinated pyrimidine Cancer Treat Rev 8 147–156 Occurrence Handle7018683 Occurrence Handle1:STN:280:Bi6B3svktFA%3D
HL Davis (1982) ArticleTitleChemotherapy of large bowel cancer Cancer 50 2638–2646 Occurrence Handle6215979 Occurrence Handle1:STN:280:BiyD2M%2FlsV0%3D Occurrence Handle10.1002/1097-0142(19820815)50:4<646::AID-CNCR2820500405>3.0.CO;2-0
A Kono Y Hara S Sugata Y Karube Y Matsushima H Ishitsuka (1983) ArticleTitleActivation of 5′-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors Chem Pharm Bull (Tokyo) 31 175–178 Occurrence Handle1:CAS:528:DyaL3sXhslamt70%3D
N Kikkawa T Taguchi K Sakai et al. (1993) ArticleTitleCombination therapy of high dose doxifluridine (5′-DFUR) + mitomycin C (MMC) for advanced or recurrent colorectal cancer. Joint Research Group in the Osaka Area for Combination Therapy of 5′-DFUR with Other Drugs [in Japanese] Gan To Kagaku Ryoho 20 117–123 Occurrence Handle8422175 Occurrence Handle1:STN:280:ByyC3srlsF0%3D
ST Malik D Talbot PI Clarke et al. (1990) ArticleTitlePhase II trial of UFT in advanced colorectal and gastric cancer Br J Cancer 62 1023–1025 Occurrence Handle2257207 Occurrence Handle1:STN:280:By6D2sjisVA%3D
K Ota T Taguchi K Kimura (1987) ArticleTitleReport on nationwide pooled data and cohort investigation in UFT Phase II study [in Japanese] Gan To Kagaku Ryoho 14 2749–2757 Occurrence Handle3115185 Occurrence Handle1:STN:280:BiiA38vps1E%3D
R Pazdur Y Lassere E Diaz-Canton DH Ho (1998) ArticleTitlePhase I trial of uracil-tegafur (UFT) plus oral leucovorin: 28-day schedule Cancer Invest 16 145–151 Occurrence Handle9541627 Occurrence Handle1:CAS:528:DyaK1cXisVKgsr8%3D
InstitutionalAuthorNameAnonymous (1992) ArticleTitleModulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project J Clin Oncol 10 896–903
R Pazdur Y Lassere V Rhodes et al. (1994) ArticleTitlePhase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma J Clin Oncol 12 2296–2300 Occurrence Handle7964943 Occurrence Handle1:STN:280:ByqD2MvisFQ%3D
W Ichikawa Z Nihei H Uetake H Yamada Y Shirota K Sugihara (2000) ArticleTitleUFT plus leucovorin for metastatic colorectal cancer: Japanese experience Oncology (Williston Park) 14 41–43 Occurrence Handle1:STN:280:DC%2BD3M7jsFCntw%3D%3D
J Carmichael T Popiela D Radstone et al. (2002) ArticleTitleRandomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer J Clin Oncol 20 3617–3627 Occurrence Handle12202662 Occurrence Handle1:CAS:528:DC%2BD38XntVynsrs%3D Occurrence Handle10.1200/JCO.2002.10.129
J-Y Douillard PM Hoff JR Skillings et al. (2002) ArticleTitleMulticenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer J Clin Oncol 20 3605–3616 Occurrence Handle12202661 Occurrence Handle1:CAS:528:DC%2BD38XntVynsro%3D Occurrence Handle10.1200/JCO.2002.04.123
K Shirao PM Hoff A Ohtsu et al. (2004) ArticleTitleComparison of the efficacy, toxicity, and pharmacokinetics of a uracil/tegafur (UFT) plus oral leucovorin (LV) regimen between Japanese and American patients with advanced colorectal cancer: joint United States and Japan study of UFT/LV J Clin Oncol 22 3466–3474 Occurrence Handle15277535 Occurrence Handle1:CAS:528:DC%2BD2cXpsVWkurs%3D Occurrence Handle10.1200/JCO.2004.05.017
M Miwa M Ura M Nishida et al. (1998) ArticleTitleDesign of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue Eur J Cancer 34 1274–1281 Occurrence Handle9849491 Occurrence Handle1:CAS:528:DyaK1cXltlCgsrk%3D Occurrence Handle10.1016/S0959-8049(98)00058-6
Y Takebayashi S Akiyama S Akiba et al. (1996) ArticleTitleClinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma J Natl Cancer Inst 88 1110–1117 Occurrence Handle8757190 Occurrence Handle1:CAS:528:DyaK28Xlslyhurc%3D
E Cutsem ParticleVan M Findlay B Osterwalder et al. (2000) ArticleTitleCapecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomized phase II study J Clin Oncol 18 1337–1345 Occurrence Handle10715306
E Cutsem ParticleVan C Twelves J Cassidy et al. (2001) ArticleTitleXeloda Colorectal Cancer Study Group. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study J Clin Oncol 19 4097–4106 Occurrence Handle11689577
PM Hoff R Ansari G Batist et al. (2001) ArticleTitleComparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study J Clin Oncol 19 2282–2292 Occurrence Handle11304782 Occurrence Handle1:CAS:528:DC%2BD3MXjsFeqsrw%3D
J Cassidy J Tabernero C Twelves et al. (2004) ArticleTitleXELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer J Clin Oncol 22 2084–2091 Occurrence Handle15169795 Occurrence Handle1:CAS:528:DC%2BD2cXpsVWlsL8%3D Occurrence Handle10.1200/JCO.2004.11.069
W Scheithauer GV Kornek M Raderer et al. (2003) ArticleTitleRandomized multicenter phase II trial of two different schedules of capecitabine plus oxaliplatin as first-line treatment in advanced colorectal cancer J Clin Oncol 21 1307–1312 Occurrence Handle12663719 Occurrence Handle1:CAS:528:DC%2BD2cXpsVWqsLk%3D Occurrence Handle10.1200/JCO.2003.09.016
J Feliu P Escudero F Llosa et al. (2005) ArticleTitleCapecitabine as first-line treatment for patients older than 70 years with metastatic colorectal cancer: an oncopaz cooperative group study J Clin Oncol 23 3104–3111 Occurrence Handle15860870 Occurrence Handle1:CAS:528:DC%2BD2MXkslGgsr8%3D Occurrence Handle10.1200/JCO.2005.06.035
RD Hofheinz B Gerstenberg-Helldorf Particlevon F Wenz et al. (2005) ArticleTitlePhase I trial of capecitabine and weekly irinotecan in combination with radiotherapy for neoadjuvant therapy of rectal cancer J Clin Oncol 23 1350–1357 Occurrence Handle15684318 Occurrence Handle1:CAS:528:DC%2BD2MXis1Gnu7s%3D Occurrence Handle10.1200/JCO.2005.04.171
T Shirasaka Y Shimamato H Ohshimo et al. (1996) ArticleTitleDevelopment of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators Anticancer Drugs 7 548–557 Occurrence Handle8862723 Occurrence Handle1:CAS:528:DyaK28Xltleru78%3D Occurrence Handle10.1097/00001813-199607000-00010
K Tatsumi M Fukushima T Shirasaka S Fujii (1987) ArticleTitleInhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts Jpn J Cancer Res 78 748–755 Occurrence Handle3114201 Occurrence Handle1:CAS:528:DyaL2sXlvFSntL8%3D
CJ Groeningen Particlevan GJ Peters JH Schornagel et al. (2000) ArticleTitlePhase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors J Clin Oncol 18 2772–2779 Occurrence Handle10894878
PM Hoff ED Saad JA Ajani et al. (2003) ArticleTitlePhase I study with pharmacokinetics of S-1 on an oral daily schedule for 28 days in patients with solid tumors Clin Cancer Res 9 134–142 Occurrence Handle12538461 Occurrence Handle1:CAS:528:DC%2BD3sXnt1Omtw%3D%3D
QS Chu LA Hammond G Schwartz et al. (2004) ArticleTitlePhase I and pharmacokinetic study of the oral fluoropyrimidine S-1 on a once-daily-for-28-day schedule in patients with advanced malignancies Clin Cancer Res 10 4913–4921 Occurrence Handle15297391 Occurrence Handle1:CAS:528:DC%2BD2cXmtlSisbk%3D Occurrence Handle10.1158/1078-0432.CCR-04-0469
J Brande ParticleVan den P Schoffski JH Schellens et al. (2003) ArticleTitleEORTC Early Clinical Studies Group. Early phase II trial of S-1 in patients with advanced or metastatic colorectal cancer Br J Cancer 88 648–653 Occurrence Handle12659110 Occurrence Handle10.1038/sj.bjc.6600781
T Taguchi Y Inuyama R Kanamaru et al. (1997) ArticleTitlePhase I study of S-1. S-1 Study Group [in Japanese] Gan To Kagaku Ryoho 24 2253–2264 Occurrence Handle9422070 Occurrence Handle1:STN:280:DyaK1c%2Fotl2rug%3D%3D
A Ohtsu H Baba Y Sakata et al. (2000) ArticleTitlePhase II study of S-1, a novel oral fluorophyrimidine derivative, in patients with metastatic colorectal carcinoma. S-1 Cooperative Colorectal Carcinoma Study Group Br J Cancer 83 141–145 Occurrence Handle10901361 Occurrence Handle1:CAS:528:DC%2BD3cXltl2mur8%3D Occurrence Handle10.1054/bjoc.2000.1236
K Shirao A Ohtsu H Takada et al. (2004) ArticleTitlePhase II study of oral S-1 for treatment of metastatic colorectal carcinoma Cancer 100 2355–2361 Occurrence Handle15160338 Occurrence Handle1:CAS:528:DC%2BD2cXltFajsr4%3D Occurrence Handle10.1002/cncr.20277
Y Komatsu S Yuuki N Fuse et al. (2005) ArticleTitlePhase II study of oral S-1 plus irinotecan in patients with advanced colorectal cancer: Hokkaido Gastrointestinal Cancer Study Group HGCSG0302 Jpn J Clin Oncol 35 88–89 Occurrence Handle15709093 Occurrence Handle10.1093/jjco/hyi025
T Matsuda M Yasutomi K Kikuchi et al. (1991) ArticleTitleCooperative study of surgical adjuvant chemotherapy for colorectal cancer: five year results [in Japanese] Gan To Kagaku Ryoho 18 461–469 Occurrence Handle1900687 Occurrence Handle1:STN:280:By6C28njsFU%3D
InstitutionalAuthorNameAnonymous (1995) ArticleTitleFive-year results of a randomized controlled trial of adjuvant chemotherapy for curatively resected colorectal carcinoma. The Colorectal Cancer Chemotherapy Study Group of Japan Jpn J Clin Oncol 25 91–103
K Ito A Yamaguchi K Miura et al. (1996) ArticleTitleOral adjuvant chemotherapy with carmofur (HCFU) for colorectal cancer: five-year follow-up J Surg Oncol 63 107–111 Occurrence Handle8888803 Occurrence Handle1:STN:280:ByiD2czntlU%3D Occurrence Handle10.1002/(SICI)1096-9098(199610)63:2<107::AID-JSO7>3.0.CO;2-I
J Sakamoto C Hamada S Kodaira H Nakazato Y Ohashi (1999) ArticleTitleAdjuvant therapy with oral fluoropyrimidines as main chemotherapeutic agents after curative resection for colorectal cancer: individual patient data meta-analysis of randomized trials Jpn J Clin Oncol 29 78–86 Occurrence Handle10089948 Occurrence Handle1:STN:280:DyaK1M7ovFyiug%3D%3D Occurrence Handle10.1093/jjco/29.2.78
J Sakamoto S Kodaira C Hamada et al. (2001) ArticleTitleAn individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer Oncol Rep 8 697–703 Occurrence Handle11295105 Occurrence Handle1:CAS:528:DC%2BD3MXjsVSitbg%3D
J Sakamoto Y Ohashi C Hamada et al. (2004) ArticleTitleEfficacy of oral adjuvant therapy after resection of colorectal cancer: 5-year results from three randomized trials J Clin Oncol 22 484–492 Occurrence Handle14752071
S Kodaira K Kikuchi M Yasutomi et al. (1998) ArticleTitlePostoperative adjuvant chemotherapy with mitomycin C and UFT for curatively resected rectal cancer: results from the Cooperative Project No.7 Group of the Japanese Foundation for Multidisciplinary Treatment of Cancer Int J Clin Oncol 3 357–364 Occurrence Handle10.1007/BF00539213
M Yasutomi T Takahashi S Kodaira et al. (1997) ArticleTitleProspective controlled study of the usefulness of Carmofur as a postoperative adjuvant chemotherapy for colorectal cancer Gan To Kagaku Ryoho 24 1953–1960 Occurrence Handle9350242 Occurrence Handle1:STN:280:DyaK1c%2FhtFeitQ%3D%3D
N Wolmark L Colangelo S Wieand (2001) ArticleTitleNational Surgical Adjuvant Breast and Bowel Project trials in colon cancer Semin Oncol 28 9–13 Occurrence Handle11273592 Occurrence Handle1:STN:280:DC%2BD3M7ntlKltw%3D%3D Occurrence Handle10.1016/S0093-7754(01)90245-3
N Wolmark S Wieand B Lembersky L Colangelo R Smith R Pazdur (2004) ArticleTitleA Phase III trial comparing oral UFT to FULV in stage II and III carcinoma of the colon: results of NSABP Protocol C-06 Proc Am Soc Clin Oncol (Post-Meeting Edition) 22 IssueID14S 247
T Akasu Y Moriya S Yoshida et al. (2004) ArticleTitleAdjuvant oral uracil and tegafur (UFT) improves survival after complete mesorectal excision (ME) for pathologic TNM stage III rectal cancer (RC): results of the National Surgical Adjuvant Study (NSAS)-Colorectal Cancer (CC) 01 randomized trial Proc Am Soc Clin Oncol (Post-Meeting Edition) 22 IssueID14S 251
J Sakamoto C Hamada M Yasutomi et al. (2005) ArticleTitleAn individual patient data meta-analysis of adjuvant therapy with carmofur in patients with curatively resected colon cancer Jpn J Clin Oncol 35 536–544 Occurrence Handle16155120 Occurrence Handle10.1093/jjco/hyi147
C Twelves A Wong MP Nowacki et al. (2005) ArticleTitleCapecitabine as adjuvant treatment for stage III colon cancer N Engl J Med 352 2696–704 Occurrence Handle15987918 Occurrence Handle1:CAS:528:DC%2BD2MXls1SktL0%3D Occurrence Handle10.1056/NEJMoa043116
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Sakamoto, J., Oba, K., Matsui, T. et al. Efficacy of Oral Anticancer Agents for Colorectal Cancer. Dis Colon Rectum 49 (Suppl 1), S82–S91 (2006). https://doi.org/10.1007/s10350-006-0601-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10350-006-0601-7