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Efficacy of Oral Anticancer Agents for Colorectal Cancer

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Diseases of the Colon & Rectum

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References

  1. MM Borner P Schoffski R Wit Particlede et al. (2002) ArticleTitlePatient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancer Eur J Cancer 38 349–358 Occurrence Handle11818199 Occurrence Handle1:CAS:528:DC%2BD38XovFShsQ%3D%3D Occurrence Handle10.1016/S0959-8049(01)00371-9

    Article  PubMed  CAS  Google Scholar 

  2. RG Hahn CG Moertel AJ Schutt HW Bruckner (1975) ArticleTitleA double-blind comparison of intensive course 5-flourouracil by oral vs. intravenous route in the treatment of colorectal carcinoma Cancer 35 1031–1035 Occurrence Handle1090358 Occurrence Handle1:STN:280:CSqC3M%2Fls1I%3D Occurrence Handle10.1002/1097-0142(197504)35:4<1031::AID-CNCR2820350403>3.0.CO;2-N

    Article  PubMed  CAS  Google Scholar 

  3. MA Friedman RJ Ignoffo (1980) ArticleTitleA review of the United States clinical experience of the fluoropyridimine, Ftorafur (NSC-148958) Cancer Treat Rev 7 205–213 Occurrence Handle6783303 Occurrence Handle1:STN:280:Bi6C283ksFI%3D Occurrence Handle10.1016/S0305-7372(80)80037-5

    Article  PubMed  CAS  Google Scholar 

  4. J Sakamoto C Hamada S Kodaira H Nakazato Y Ohashi (1999) ArticleTitleAdjuvant therapy with oral fluoropyrimidines as main chemotherapeutic agents after curative resection for colorectal cancer: individual patient data meta-analysis of randomized trials Jpn J Clin Oncol 29 78–86 Occurrence Handle10089948 Occurrence Handle1:STN:280:DyaK1M7ovFyiug%3D%3D Occurrence Handle10.1093/jjco/29.2.78

    Article  PubMed  CAS  Google Scholar 

  5. A Hoshi M Iigo M Yoshida K Kuretani (1975) ArticleTitleAntitumor activity of carbamoyl derivatives of 5-fluorouracil by oral administration Gann 66 673–674 Occurrence Handle1225720 Occurrence Handle1:CAS:528:DyaE28XhtFGkur8%3D

    PubMed  CAS  Google Scholar 

  6. A Hoshi M Iigo A Nakamura M Yoshida K Kuretani (1976) ArticleTitleAntitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors Gann 67 725–731 Occurrence Handle1017587 Occurrence Handle1:CAS:528:DyaE2sXltVGqsg%3D%3D

    PubMed  CAS  Google Scholar 

  7. InstitutionalAuthorNameHCFU Clinical Study Group (1980) ArticleTitleAbsorption and excretion of new oral antitumor drug, 1-hexylcarbamoyl-5-fluorouracil (HCFU), in cancer patients Jpn J Clin Oncol 10 83–92

    Google Scholar 

  8. M Iigo A Hoshi A Nakamura K Kuretani (1978) ArticleTitleAntitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil in a variety of mouse tumors Cancer Chemother Pharmacol 1 203–208 Occurrence Handle750108 Occurrence Handle1:CAS:528:DyaE1MXktlalt78%3D Occurrence Handle10.1007/BF00257150

    Article  PubMed  CAS  Google Scholar 

  9. Y Koyama (1981) ArticleTitle1-hexylcarbamoyl-5-fluorouracil (HCFU): a masked 5-fluorinated pyrimidine Cancer Treat Rev 8 147–156 Occurrence Handle7018683 Occurrence Handle1:STN:280:Bi6B3svktFA%3D

    PubMed  CAS  Google Scholar 

  10. HL Davis (1982) ArticleTitleChemotherapy of large bowel cancer Cancer 50 2638–2646 Occurrence Handle6215979 Occurrence Handle1:STN:280:BiyD2M%2FlsV0%3D Occurrence Handle10.1002/1097-0142(19820815)50:4<646::AID-CNCR2820500405>3.0.CO;2-0

    Article  PubMed  CAS  Google Scholar 

  11. A Kono Y Hara S Sugata Y Karube Y Matsushima H Ishitsuka (1983) ArticleTitleActivation of 5′-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors Chem Pharm Bull (Tokyo) 31 175–178 Occurrence Handle1:CAS:528:DyaL3sXhslamt70%3D

    CAS  Google Scholar 

  12. N Kikkawa T Taguchi K Sakai et al. (1993) ArticleTitleCombination therapy of high dose doxifluridine (5′-DFUR) + mitomycin C (MMC) for advanced or recurrent colorectal cancer. Joint Research Group in the Osaka Area for Combination Therapy of 5′-DFUR with Other Drugs [in Japanese] Gan To Kagaku Ryoho 20 117–123 Occurrence Handle8422175 Occurrence Handle1:STN:280:ByyC3srlsF0%3D

    PubMed  CAS  Google Scholar 

  13. ST Malik D Talbot PI Clarke et al. (1990) ArticleTitlePhase II trial of UFT in advanced colorectal and gastric cancer Br J Cancer 62 1023–1025 Occurrence Handle2257207 Occurrence Handle1:STN:280:By6D2sjisVA%3D

    PubMed  CAS  Google Scholar 

  14. K Ota T Taguchi K Kimura (1987) ArticleTitleReport on nationwide pooled data and cohort investigation in UFT Phase II study [in Japanese] Gan To Kagaku Ryoho 14 2749–2757 Occurrence Handle3115185 Occurrence Handle1:STN:280:BiiA38vps1E%3D

    PubMed  CAS  Google Scholar 

  15. R Pazdur Y Lassere E Diaz-Canton DH Ho (1998) ArticleTitlePhase I trial of uracil-tegafur (UFT) plus oral leucovorin: 28-day schedule Cancer Invest 16 145–151 Occurrence Handle9541627 Occurrence Handle1:CAS:528:DyaK1cXisVKgsr8%3D

    PubMed  CAS  Google Scholar 

  16. InstitutionalAuthorNameAnonymous (1992) ArticleTitleModulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project J Clin Oncol 10 896–903

    Google Scholar 

  17. R Pazdur Y Lassere V Rhodes et al. (1994) ArticleTitlePhase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma J Clin Oncol 12 2296–2300 Occurrence Handle7964943 Occurrence Handle1:STN:280:ByqD2MvisFQ%3D

    PubMed  CAS  Google Scholar 

  18. W Ichikawa Z Nihei H Uetake H Yamada Y Shirota K Sugihara (2000) ArticleTitleUFT plus leucovorin for metastatic colorectal cancer: Japanese experience Oncology (Williston Park) 14 41–43 Occurrence Handle1:STN:280:DC%2BD3M7jsFCntw%3D%3D

    CAS  Google Scholar 

  19. J Carmichael T Popiela D Radstone et al. (2002) ArticleTitleRandomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer J Clin Oncol 20 3617–3627 Occurrence Handle12202662 Occurrence Handle1:CAS:528:DC%2BD38XntVynsrs%3D Occurrence Handle10.1200/JCO.2002.10.129

    Article  PubMed  CAS  Google Scholar 

  20. J-Y Douillard PM Hoff JR Skillings et al. (2002) ArticleTitleMulticenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer J Clin Oncol 20 3605–3616 Occurrence Handle12202661 Occurrence Handle1:CAS:528:DC%2BD38XntVynsro%3D Occurrence Handle10.1200/JCO.2002.04.123

    Article  PubMed  CAS  Google Scholar 

  21. K Shirao PM Hoff A Ohtsu et al. (2004) ArticleTitleComparison of the efficacy, toxicity, and pharmacokinetics of a uracil/tegafur (UFT) plus oral leucovorin (LV) regimen between Japanese and American patients with advanced colorectal cancer: joint United States and Japan study of UFT/LV J Clin Oncol 22 3466–3474 Occurrence Handle15277535 Occurrence Handle1:CAS:528:DC%2BD2cXpsVWkurs%3D Occurrence Handle10.1200/JCO.2004.05.017

    Article  PubMed  CAS  Google Scholar 

  22. M Miwa M Ura M Nishida et al. (1998) ArticleTitleDesign of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue Eur J Cancer 34 1274–1281 Occurrence Handle9849491 Occurrence Handle1:CAS:528:DyaK1cXltlCgsrk%3D Occurrence Handle10.1016/S0959-8049(98)00058-6

    Article  PubMed  CAS  Google Scholar 

  23. Y Takebayashi S Akiyama S Akiba et al. (1996) ArticleTitleClinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma J Natl Cancer Inst 88 1110–1117 Occurrence Handle8757190 Occurrence Handle1:CAS:528:DyaK28Xlslyhurc%3D

    PubMed  CAS  Google Scholar 

  24. E Cutsem ParticleVan M Findlay B Osterwalder et al. (2000) ArticleTitleCapecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomized phase II study J Clin Oncol 18 1337–1345 Occurrence Handle10715306

    PubMed  Google Scholar 

  25. E Cutsem ParticleVan C Twelves J Cassidy et al. (2001) ArticleTitleXeloda Colorectal Cancer Study Group. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study J Clin Oncol 19 4097–4106 Occurrence Handle11689577

    PubMed  Google Scholar 

  26. PM Hoff R Ansari G Batist et al. (2001) ArticleTitleComparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study J Clin Oncol 19 2282–2292 Occurrence Handle11304782 Occurrence Handle1:CAS:528:DC%2BD3MXjsFeqsrw%3D

    PubMed  CAS  Google Scholar 

  27. J Cassidy J Tabernero C Twelves et al. (2004) ArticleTitleXELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer J Clin Oncol 22 2084–2091 Occurrence Handle15169795 Occurrence Handle1:CAS:528:DC%2BD2cXpsVWlsL8%3D Occurrence Handle10.1200/JCO.2004.11.069

    Article  PubMed  CAS  Google Scholar 

  28. W Scheithauer GV Kornek M Raderer et al. (2003) ArticleTitleRandomized multicenter phase II trial of two different schedules of capecitabine plus oxaliplatin as first-line treatment in advanced colorectal cancer J Clin Oncol 21 1307–1312 Occurrence Handle12663719 Occurrence Handle1:CAS:528:DC%2BD2cXpsVWqsLk%3D Occurrence Handle10.1200/JCO.2003.09.016

    Article  PubMed  CAS  Google Scholar 

  29. J Feliu P Escudero F Llosa et al. (2005) ArticleTitleCapecitabine as first-line treatment for patients older than 70 years with metastatic colorectal cancer: an oncopaz cooperative group study J Clin Oncol 23 3104–3111 Occurrence Handle15860870 Occurrence Handle1:CAS:528:DC%2BD2MXkslGgsr8%3D Occurrence Handle10.1200/JCO.2005.06.035

    Article  PubMed  CAS  Google Scholar 

  30. RD Hofheinz B Gerstenberg-Helldorf Particlevon F Wenz et al. (2005) ArticleTitlePhase I trial of capecitabine and weekly irinotecan in combination with radiotherapy for neoadjuvant therapy of rectal cancer J Clin Oncol 23 1350–1357 Occurrence Handle15684318 Occurrence Handle1:CAS:528:DC%2BD2MXis1Gnu7s%3D Occurrence Handle10.1200/JCO.2005.04.171

    Article  PubMed  CAS  Google Scholar 

  31. T Shirasaka Y Shimamato H Ohshimo et al. (1996) ArticleTitleDevelopment of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators Anticancer Drugs 7 548–557 Occurrence Handle8862723 Occurrence Handle1:CAS:528:DyaK28Xltleru78%3D Occurrence Handle10.1097/00001813-199607000-00010

    Article  PubMed  CAS  Google Scholar 

  32. K Tatsumi M Fukushima T Shirasaka S Fujii (1987) ArticleTitleInhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts Jpn J Cancer Res 78 748–755 Occurrence Handle3114201 Occurrence Handle1:CAS:528:DyaL2sXlvFSntL8%3D

    PubMed  CAS  Google Scholar 

  33. CJ Groeningen Particlevan GJ Peters JH Schornagel et al. (2000) ArticleTitlePhase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors J Clin Oncol 18 2772–2779 Occurrence Handle10894878

    PubMed  Google Scholar 

  34. PM Hoff ED Saad JA Ajani et al. (2003) ArticleTitlePhase I study with pharmacokinetics of S-1 on an oral daily schedule for 28 days in patients with solid tumors Clin Cancer Res 9 134–142 Occurrence Handle12538461 Occurrence Handle1:CAS:528:DC%2BD3sXnt1Omtw%3D%3D

    PubMed  CAS  Google Scholar 

  35. QS Chu LA Hammond G Schwartz et al. (2004) ArticleTitlePhase I and pharmacokinetic study of the oral fluoropyrimidine S-1 on a once-daily-for-28-day schedule in patients with advanced malignancies Clin Cancer Res 10 4913–4921 Occurrence Handle15297391 Occurrence Handle1:CAS:528:DC%2BD2cXmtlSisbk%3D Occurrence Handle10.1158/1078-0432.CCR-04-0469

    Article  PubMed  CAS  Google Scholar 

  36. J Brande ParticleVan den P Schoffski JH Schellens et al. (2003) ArticleTitleEORTC Early Clinical Studies Group. Early phase II trial of S-1 in patients with advanced or metastatic colorectal cancer Br J Cancer 88 648–653 Occurrence Handle12659110 Occurrence Handle10.1038/sj.bjc.6600781

    Article  PubMed  Google Scholar 

  37. T Taguchi Y Inuyama R Kanamaru et al. (1997) ArticleTitlePhase I study of S-1. S-1 Study Group [in Japanese] Gan To Kagaku Ryoho 24 2253–2264 Occurrence Handle9422070 Occurrence Handle1:STN:280:DyaK1c%2Fotl2rug%3D%3D

    PubMed  CAS  Google Scholar 

  38. A Ohtsu H Baba Y Sakata et al. (2000) ArticleTitlePhase II study of S-1, a novel oral fluorophyrimidine derivative, in patients with metastatic colorectal carcinoma. S-1 Cooperative Colorectal Carcinoma Study Group Br J Cancer 83 141–145 Occurrence Handle10901361 Occurrence Handle1:CAS:528:DC%2BD3cXltl2mur8%3D Occurrence Handle10.1054/bjoc.2000.1236

    Article  PubMed  CAS  Google Scholar 

  39. K Shirao A Ohtsu H Takada et al. (2004) ArticleTitlePhase II study of oral S-1 for treatment of metastatic colorectal carcinoma Cancer 100 2355–2361 Occurrence Handle15160338 Occurrence Handle1:CAS:528:DC%2BD2cXltFajsr4%3D Occurrence Handle10.1002/cncr.20277

    Article  PubMed  CAS  Google Scholar 

  40. Y Komatsu S Yuuki N Fuse et al. (2005) ArticleTitlePhase II study of oral S-1 plus irinotecan in patients with advanced colorectal cancer: Hokkaido Gastrointestinal Cancer Study Group HGCSG0302 Jpn J Clin Oncol 35 88–89 Occurrence Handle15709093 Occurrence Handle10.1093/jjco/hyi025

    Article  PubMed  Google Scholar 

  41. T Matsuda M Yasutomi K Kikuchi et al. (1991) ArticleTitleCooperative study of surgical adjuvant chemotherapy for colorectal cancer: five year results [in Japanese] Gan To Kagaku Ryoho 18 461–469 Occurrence Handle1900687 Occurrence Handle1:STN:280:By6C28njsFU%3D

    PubMed  CAS  Google Scholar 

  42. InstitutionalAuthorNameAnonymous (1995) ArticleTitleFive-year results of a randomized controlled trial of adjuvant chemotherapy for curatively resected colorectal carcinoma. The Colorectal Cancer Chemotherapy Study Group of Japan Jpn J Clin Oncol 25 91–103

    Google Scholar 

  43. K Ito A Yamaguchi K Miura et al. (1996) ArticleTitleOral adjuvant chemotherapy with carmofur (HCFU) for colorectal cancer: five-year follow-up J Surg Oncol 63 107–111 Occurrence Handle8888803 Occurrence Handle1:STN:280:ByiD2czntlU%3D Occurrence Handle10.1002/(SICI)1096-9098(199610)63:2<107::AID-JSO7>3.0.CO;2-I

    Article  PubMed  CAS  Google Scholar 

  44. J Sakamoto C Hamada S Kodaira H Nakazato Y Ohashi (1999) ArticleTitleAdjuvant therapy with oral fluoropyrimidines as main chemotherapeutic agents after curative resection for colorectal cancer: individual patient data meta-analysis of randomized trials Jpn J Clin Oncol 29 78–86 Occurrence Handle10089948 Occurrence Handle1:STN:280:DyaK1M7ovFyiug%3D%3D Occurrence Handle10.1093/jjco/29.2.78

    Article  PubMed  CAS  Google Scholar 

  45. J Sakamoto S Kodaira C Hamada et al. (2001) ArticleTitleAn individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer Oncol Rep 8 697–703 Occurrence Handle11295105 Occurrence Handle1:CAS:528:DC%2BD3MXjsVSitbg%3D

    PubMed  CAS  Google Scholar 

  46. J Sakamoto Y Ohashi C Hamada et al. (2004) ArticleTitleEfficacy of oral adjuvant therapy after resection of colorectal cancer: 5-year results from three randomized trials J Clin Oncol 22 484–492 Occurrence Handle14752071

    PubMed  Google Scholar 

  47. S Kodaira K Kikuchi M Yasutomi et al. (1998) ArticleTitlePostoperative adjuvant chemotherapy with mitomycin C and UFT for curatively resected rectal cancer: results from the Cooperative Project No.7 Group of the Japanese Foundation for Multidisciplinary Treatment of Cancer Int J Clin Oncol 3 357–364 Occurrence Handle10.1007/BF00539213

    Article  Google Scholar 

  48. M Yasutomi T Takahashi S Kodaira et al. (1997) ArticleTitleProspective controlled study of the usefulness of Carmofur as a postoperative adjuvant chemotherapy for colorectal cancer Gan To Kagaku Ryoho 24 1953–1960 Occurrence Handle9350242 Occurrence Handle1:STN:280:DyaK1c%2FhtFeitQ%3D%3D

    PubMed  CAS  Google Scholar 

  49. N Wolmark L Colangelo S Wieand (2001) ArticleTitleNational Surgical Adjuvant Breast and Bowel Project trials in colon cancer Semin Oncol 28 9–13 Occurrence Handle11273592 Occurrence Handle1:STN:280:DC%2BD3M7ntlKltw%3D%3D Occurrence Handle10.1016/S0093-7754(01)90245-3

    Article  PubMed  CAS  Google Scholar 

  50. N Wolmark S Wieand B Lembersky L Colangelo R Smith R Pazdur (2004) ArticleTitleA Phase III trial comparing oral UFT to FULV in stage II and III carcinoma of the colon: results of NSABP Protocol C-06 Proc Am Soc Clin Oncol (Post-Meeting Edition) 22 IssueID14S 247

    Google Scholar 

  51. T Akasu Y Moriya S Yoshida et al. (2004) ArticleTitleAdjuvant oral uracil and tegafur (UFT) improves survival after complete mesorectal excision (ME) for pathologic TNM stage III rectal cancer (RC): results of the National Surgical Adjuvant Study (NSAS)-Colorectal Cancer (CC) 01 randomized trial Proc Am Soc Clin Oncol (Post-Meeting Edition) 22 IssueID14S 251

    Google Scholar 

  52. J Sakamoto C Hamada M Yasutomi et al. (2005) ArticleTitleAn individual patient data meta-analysis of adjuvant therapy with carmofur in patients with curatively resected colon cancer Jpn J Clin Oncol 35 536–544 Occurrence Handle16155120 Occurrence Handle10.1093/jjco/hyi147

    Article  PubMed  Google Scholar 

  53. C Twelves A Wong MP Nowacki et al. (2005) ArticleTitleCapecitabine as adjuvant treatment for stage III colon cancer N Engl J Med 352 2696–704 Occurrence Handle15987918 Occurrence Handle1:CAS:528:DC%2BD2MXls1SktL0%3D Occurrence Handle10.1056/NEJMoa043116

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Junichi Sakamoto M.D., Ph.D..

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Sakamoto, J., Oba, K., Matsui, T. et al. Efficacy of Oral Anticancer Agents for Colorectal Cancer. Dis Colon Rectum 49 (Suppl 1), S82–S91 (2006). https://doi.org/10.1007/s10350-006-0601-7

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